2H-PYRAN-3(4H)-ONE, DIHYDRO-

Product Name: 2H-PYRAN-3(4H)-ONE, DIHYDRO-
CAS No.: 23462-75-1
Chemical Name: 2H-PYRAN-3(4H)-ONE, DIHYDRO-
Synonyms: Tetrahydropyran-3-One;DIHYDRO-PYRAN-3-ONE;oxan-3-one;2H-PYRAN-3(4H)-ONE;tetrahydro-2H-3-pyranone;Tetrahydro-2H-pyran-3-one;2H-Pypan-3(4H)-one, dihydro-;2H-PYRAN-3(4H)-ONE, DIHYD...;2H-PYRAN-3(4H)-ONE, DIHYDRO-;5,6-Dihydro-2H-pyran-3(4H)-one
CBNumber: CB0105291
Molecular Formula: C5H8O2
Formula Weight: 100.12
MOL File: 23462-75-1.mol

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2H-PYRAN-3(4H)-ONE, DIHYDRO- Property

Boiling point:: 55 °C(Press: 12 Torr)
Density: 1.0856 g/cm3
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: liquid
color: Colourless
InChI: InChI=1S/C5H8O2/c6-5-2-1-3-7-4-5/h1-4H2
InChIKey: URUUZIAJVSGYRC-UHFFFAOYSA-N
SMILES: C1OCCCC1=O

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Safety

HazardClass: IRRITANT
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: D450560
Product name: Dihydro-2H-pyran-3(4H)-one
Packaging: 100mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD51738
Product name: Dihydro-2H-pyran-3(4H)-one
Packaging: 1g
Price: $65
Updated: 2021/12/16

Apolloscientific

Product number: OR301349
Product name: Dihydro-2H-pyran-3(4H)-one
Purity: 95+%
Packaging: 1g
Price: $86
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H17-1-09
Product name: Oxan-3-one
Packaging: 1g
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD51738
Product name: Dihydro-2H-pyran-3(4H)-one
Packaging: 2g
Price: $100
Updated: 2021/12/16

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2H-PYRAN-3(4H)-ONE, DIHYDRO- Chemical Properties,Usage,Production

Uses

Dihydro-?2H-?pyran-?3(4H)?-?one is a general chemical reagent used in the synthesis of pharmaceuticals such as the preparation of tetrahydropyran-2-yl chromans, a highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE) inhibitor.

Synthesis

19752-84-2

23462-75-1

The general procedure for the synthesis of dihydro-2H-pyran-3(4H)-ones using 3-hydroxytetrahydropyran as starting material was as follows: 3-hydroxytetrahydropyran (300 g, 2.9 mol) was dissolved in dichloromethane (3,000 g), followed by the addition of sodium acetate (287 g, 3.5 mol) and TEMPO (6 g). Sodium dichloroisocyanurate (374 g, 1.7 mol) was added in batches at 25 °C and the reaction temperature was maintained at 25 °C for a continuous period of 2 hours. After completion of the reaction, filtration was carried out and the organic phase was dried with anhydrous sodium sulfate (200 g). After filtration again, it was concentrated under reduced pressure using a rotary evaporator and distilled to collect a fraction with an oil bath temperature of 120 °C and a top temperature of 90 °C of the distillate. The final product was obtained as a colorless oily liquid which was tested to be 99% pure and 83% yield.

References

[1] Heterocycles, 2011, vol. 82, # 2, p. 1267 - 1282
[2] Patent: CN107382928, 2017, A. Location in patent: Paragraph 0007-0008; 0010-0011; 0013-0014
[3] Liebigs Annalen der Chemie, 1983, # 11, p. 1950 - 1958
[4] Tetrahedron, 2003, vol. 59, # 9, p. 1453 - 1467
[5] Patent: CN104650049, 2018, B. Location in patent: Paragraph 0603; 0604

2H-PYRAN-3(4H)-ONE, DIHYDRO- Preparation Products And Raw materials

Raw materials

Preparation Products

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2H-PYRAN-3(4H)-ONE, DIHYDRO- Suppliers

China 179 India 3 United Kingdom 2 United States 17 Global 201

Hebei Yaocheng Pharmaceutical Technology Co. Ltd

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skychemical Co.Ltd

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View Lastest Price from 2H-PYRAN-3(4H)-ONE, DIHYDRO- manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Dihydro-pyran-3-one 23462-75-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97%min
Supply Ability: 30tons/month
Release date: 2023-02-22

Zjartschem

Product: Dihydro-2H-pyran-3(4H)-one 23462-75-1
Price: US $0.00/g
Min. Order: 100g
Purity: 97%
Supply Ability: 100kg
Release date: 2019-02-13

Henan Fengda Chemical Co., Ltd

Product: Dihydro-2H-pyran-3(4H)-one 23462-75-1
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

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23462-75-1