5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE

Application

Product Name: 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE
CAS No.: 398491-59-3
Chemical Name: 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE
Synonyms: tert-butyl 3-aMinopyrrolo[3;5-Boc-3-amino-4,6-dihydro...;3-Amino-5-Boc-pyrrolo[3,4-c]pyrazole;5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYROZOLE;5-Boc-3-Amino-4,6-dihydro-pyrrolo[3,4-C]pyrazole;5-Boc-3-amino-1,4,6-trihydropyrrolo[3,4-c]pyrazole;5-Boc-3-amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole;3-Amino-5-Boc-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole;5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE;5N-boc-3-amino-4,6-dihydro-1H-pyrrolo[3,5-c]pyrozole
CBNumber: CB2191315
Molecular Formula: C10H16N4O2
Formula Weight: 224.26
MOL File: 398491-59-3.mol

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5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE Property

Melting point:: 167-169 °C(Solv: isopropanol (67-63-0))
Boiling point:: 433.0±45.0 °C(Predicted)
Density: 1.314±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 16.32±0.20(Predicted)
Appearance: Off-white to light brown Solid
InChI: InChI=1S/C10H16N4O2/c1-10(2,3)16-9(15)14-4-6-7(5-14)12-13-8(6)11/h4-5H2,1-3H3,(H3,11,12,13)
InChIKey: BEVRTOCHMXNPLY-UHFFFAOYSA-N
SMILES: N1=C(N)C2CN(C(OC(C)(C)C)=O)CC=2N1
CAS DataBase Reference: 398491-59-3

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B695340
Product name: tert-Butyl3-Amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B695340
Product name: tert-Butyl3-Amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

ChemScene

Product number: CS-W004901
Product name: tert-Butyl3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate
Purity: 98.40%
Packaging: 1g
Price: $58
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144392
Product name: tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate
Packaging: 250mg
Price: $87.5
Updated: 2021/12/16

Matrix Scientific

Product number: 069254
Product name: tert-Butyl 3-Amino-4,6-dihydropyrrolo-[3,4-c]-pyrazole-5(1H)-carboxylate
Purity: 95+%
Packaging: 1g
Price: $120
Updated: 2021/12/16

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5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE Chemical Properties,Usage,Production

Application

5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE can be used as an organic synthesis intermediate and a pharmaceutical intermediate, and is mainly used in laboratory organic synthesis and chemical and pharmaceutical synthesis processes.

Synthesis

175463-32-8

398491-59-3

The general procedure for the synthesis of 3-amino-5-tert-butoxycarbonyl-pyrrolo[3,4-C]pyrazole from 1-Boc-3-cyano-4-pyrrolidinone was as follows: 1-Boc-3-cyano-4-pyrrolidinone (4.5 g, 43 mmol) was dissolved in anhydrous ethanol (250 ml), and the reaction was stirred for 3 h at 60 °C. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Saturated sodium bicarbonate solution (50 ml) was added to the residue until the solid was completely dissolved. Subsequently, the extracted organic phase was removed by evaporation under reduced pressure to give the white solid product 1b (6.3 g, 66% yield). The product did not require further purification and could be used directly in the next step of the reaction.

References

[1] Patent: CN106279177, 2017, A. Location in patent: Paragraph 0103; 0104; 0105
[2] Journal of Medicinal Chemistry, 2005, vol. 48, # 8, p. 3080 - 3084
[3] Patent: WO2007/87231, 2007, A2. Location in patent: Page/Page column 37
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 14, p. 4273 - 4278
[5] Patent: CN104072498, 2016, B. Location in patent: Paragraph 0150

5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE Suppliers

China 131 Germany 2 India 1 United Kingdom 2 United States 20 Global 156

Pure Chemistry Scientific Inc.

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View Lastest Price from 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE 398491-59-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-05-20

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD

Product: tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate 398491-59-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500 kgs
Release date: 2024-07-08

Career Henan Chemical Co

Product: 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE 398491-59-3
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

398491-59-3, 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLERelated Search:

TERT-BUTYL 3-AMINO-6,6-DIMETHYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE 1H-Pyrrol-3-amine(9CI) 1-AMINOPYRROLE tert-butyl 3-aminopyrazole-l- carboxylate 1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester 5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE 5-tert-butyl 1-ethyl 3-amino-3a,4,6,6a-tetrahydropyrrolo[3,4-c]pyrazole-1,5-dicarboxylate 1-ETHYLOXYCARBONYL-5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE 1-ETHYLOXYCARBONYL-3-[4-(4-METHYL-PIPERAZIN-1-YL)-BENZOYLAMINO]-5-BOC-4,6-DIHYDRO-PYRROLO[3,4-C]PYRAZOLE TERT-BUTYL 3'-AMINO-1'H-SPIRO[CYCLOPROPANE-1,6'-PYRROLO[3,4-C]PYRAZOLE]-5'(4'H)-CARBOXYLATE tert-butyl 3-amino-6-ethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate

5N-BOC-3-AMINO-4,6-DIHYDRO-1H-PYRROLO[3,4-C]PYROZOLE

TERT-BUTYL 3-AMINO-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(1H)-CARBOXYLATE

5-BOC-3-AMINO-4,6-DIHYDRO-PYRROLO[3,4-C]PYROZOLE

tert-butyl 3-aminopyrrolo[3,4-c]pyrazole-5(1H,4H,6H)-carboxylate

tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-C]pyrozole-5-carboxylate

5-Boc-3-amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole

3-Amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester

5-Boc-3-amino-4,6-dihydro...

tert-butyl 3-aMinopyrrolo[3

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole, N5-BOC protected

3-Amino-5-(tert-butoxycarbonyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole, tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate

tert-butyl 3-aMino-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazole-5-carboxylate

3-aMino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl este

3-Amino-5-Boc-pyrrolo[3,4-c]pyrazole

3-Amino-5-Boc-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole

tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carboxylate

tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)

Pyrrolo[3,4-c]pyrazole-5(1H)-carboxylic acid, 3-amino-4,6-dihydro-, 1,1-dimethylethyl ester

3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole, N5-BOC protected 98%

tert-butyl 3-amino-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazole-5-carboxylate

5-Boc-3-Amino-4,6-dihydro-pyrrolo[3,4-C]pyrazole

5-Boc-3-amino-1,4,6-trihydropyrrolo[3,4-c]pyrazole

5N-boc-3-amino-4,6-dihydro-1H-pyrrolo[3,5-c]pyrozole

3-amino-2,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester

398491-59-3

CHIRAL CHEMICALS