ChemicalBook > CAS DataBase List > 1-BENZYLPYRROLIDIN-3-YL-METHANOL

1-BENZYLPYRROLIDIN-3-YL-METHANOL

Product Name
1-BENZYLPYRROLIDIN-3-YL-METHANOL
CAS No.
5731-17-9
Chemical Name
1-BENZYLPYRROLIDIN-3-YL-METHANOL
Synonyms
CHEMBRDG-BB 4003810;1-BENZYL-DL-BETA-PROLINOL;1-Benzylpyrrolidine-3-methanol;1-Benzyl-3-pyrrolidinemethanol;1-BENZYL-3-PYRROLIDIN-3-YLMETHANOL;1-BENZYL-3-HYDROXYMETHYLPYRROLIDINE;1-Benzyl-1H-pyrrolidin-3-yl-Methanol;(1-Benzyl-1H-pyrrolidin-3-yl)Methanol;3-HYDROXYMETHYL-N-BENZYL- PYRROLIDINE;1-(Phenylmethyl)-3-pyrrolidinemethanol
CBNumber
CB2194664
Molecular Formula
C12H17NO
Formula Weight
191.27
MOL File
5731-17-9.mol
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1-BENZYLPYRROLIDIN-3-YL-METHANOL Property

Boiling point:
129 °C(Press: 0.9 Torr)
Density 
1.082±0.06 g/cm3(Predicted)
storage temp. 
Store at room temperature
form 
solid
pka
14.93±0.10(Predicted)
Appearance
Light yellow to yellow Viscous liquid
InChI
InChI=1S/C12H17NO/c14-10-12-6-7-13(9-12)8-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2
InChIKey
QPQQBJDSKDWQMJ-UHFFFAOYSA-N
SMILES
N1(CC2=CC=CC=C2)CCC(CO)C1
CAS DataBase Reference
5731-17-9(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ADE000012
Product name
1-Benzylpyrrolidin-3-yl-methanol
Purity
Aldrich
Packaging
1g
Price
$179
Updated
2025/07/31
TRC
Product number
B289065
Product name
(1-Benzylpyrrolidin-3-yl)methanol
Packaging
100mg
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50914
Product name
1-Benzylpyrrolidin-3-yl-methanol
Packaging
500mg
Price
$100
Updated
2021/12/16
Matrix Scientific
Product number
018164
Product name
1-Benzylpyrrolidin-3-yl-methanol
Packaging
1g
Price
$37
Updated
2021/12/16
Apolloscientific
Product number
OR901559
Product name
1-Benzylpyrrolidin-3-yl-methanol
Purity
97%
Packaging
1g
Price
$116
Updated
2021/12/16
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1-BENZYLPYRROLIDIN-3-YL-METHANOL Chemical Properties,Usage,Production

Synthesis

51535-00-3

5731-17-9

Example A: Synthesis of N-benzyl-3-hydroxymethylpyrrolidine Step a: Reduction of methyl 1-benzyl-5-oxopyrrolidine-3-carboxylate to 1-benzyl-3-hydroxymethylpyrrolidine Under an inert atmosphere, methyl 1-benzyl-5-oxopyrrolidine-3-carboxylate (1.0 equiv, commercially available) was dissolved in toluene and the mixture was cooled to 0 °C. To the cooled mixture was slowly added a dimethyl sulfide solution of borane-dimethyl sulfide complex (3.75 equiv.). The reaction mixture was heated to 100°C-110°C and refluxed for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature, further cooled to -5 °C to -10 °C, and then sodium bicarbonate solution was added dropwise. The mixture was slowly warmed to room temperature and then refluxed for 2 hours. After the reaction mixture was cooled, the organic layer was separated and the aqueous layer was extracted with toluene. The combined toluene layers were washed sequentially with water and brine. Finally, the organic solvent was removed by evaporation under reduced pressure to afford the target product N-benzyl-3-hydroxymethylpyrrolidine in 99.14% yield.

References

[1] Patent: WO2006/18708, 2006, A2. Location in patent: Page/Page column 21-22
[2] Letters in Organic Chemistry, 2011, vol. 8, # 3, p. 155 - 162
[3] Patent: US2004/147502, 2004, A1. Location in patent: Page/Page column 36-37
[4] Organic Letters, 1999, vol. 1, # 5, p. 799 - 801
[5] Patent: US2005/165005, 2005, A1. Location in patent: Page/Page column 59-60

1-BENZYLPYRROLIDIN-3-YL-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BENZYLPYRROLIDIN-3-YL-METHANOL Suppliers

Canada 1 China 109 Germany 2 India 2 United Kingdom 2 United States 20 Global 136
Anhui Dexinjia Biopharm Co., Ltd
Tel
0531-82375892 15553111391
Email
3276840968@qq.com
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China
ProdList
301
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58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
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56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
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66
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd.
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21-54820552 18964669552
Fax
086-21-64964478
Email
188738128@qq.com
Country
China
ProdList
310
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66
Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
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United States
ProdList
10186
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Shanghai Longsheng chemical Co.,Ltd.
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021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
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China
ProdList
9883
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Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
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64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
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66
Beijing HengPuGao Pharmaceutical Chemistry Technology Co., Ltd.
Tel
010-81520996 13439320863
Fax
010-81520996
Email
hengpugao@126.com
Country
China
ProdList
159
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View Lastest Price from 1-BENZYLPYRROLIDIN-3-YL-METHANOL manufacturers

Career Henan Chemical Co
Product
1-BENZYLPYRROLIDIN-3-YL-METHANOL 5731-17-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-12-25
Career Henan Chemical Co
Product
1-BENZYLPYRROLIDIN-3-YL-METHANOL 5731-17-9
Price
US $1.00/kg
Min. Order
1kg
Purity
95%-99%
Supply Ability
100kg
Release date
2018-12-25

5731-17-9, 1-BENZYLPYRROLIDIN-3-YL-METHANOLRelated Search:

Octazamide 3-Hydroxymethylpyrrolidine 1-BENZYLPYRROLE 1-(4-METHYL-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Methyl 1-Benzyl-5-oxopyrrolidine-3-carboxylate 1-(4-FLUOROBENZYL)-5-OXO-3-PYRROLIDINECARBOXYLIC ACID 1-(4-CHLOROBENZYL)-5-OXOPYRROLIDINE-3-CARBOXYLIC ACID Ethyl 1-(4-methoxybenzoyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxylate 5-OXO-1-(1-PHENYL-ETHYL)-PYRROLIDINE-3-CARBOXYLIC ACID 5-OXO-1-[4-(TRIFLUOROMETHYL)BENZYL]PYRROLIDINE-3-CARBOXYLIC ACID (1'R, 3R)-1-(1'-PHENYLETHYL)-5-OXO-3-PYRROLIDINE CARBOXYLIC ACID 1-(2-METHOXY-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 1-(2-CHLOROBENZYL)-5-OXOPYRROLIDINE-3-CARBOXYLIC ACID 1-BENZYL-2-(4-METHOXY-PHENYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 1-BENZYL-5-OXO-3-PYRROLIDINECARBOXYLIC ACID 4-BENZYL-10-OXA-4-AZATRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE 1-BENZYL-(2R,4R)-4-AMINO-PYRROLIDINE-2,4-DICARBOXYLIC ACID HCL 1-BENZYL-5-OXO-2-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID

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