1-BENZYLPYRROLIDIN-3-YL-METHANOL

Product Name: 1-BENZYLPYRROLIDIN-3-YL-METHANOL
CAS No.: 5731-17-9
Chemical Name: 1-BENZYLPYRROLIDIN-3-YL-METHANOL
Synonyms: CHEMBRDG-BB 4003810;1-BENZYL-DL-BETA-PROLINOL;1-Benzylpyrrolidine-3-methanol;1-Benzyl-3-pyrrolidinemethanol;1-BENZYL-3-PYRROLIDIN-3-YLMETHANOL;1-BENZYL-3-HYDROXYMETHYLPYRROLIDINE;1-Benzyl-1H-pyrrolidin-3-yl-Methanol;(1-Benzyl-1H-pyrrolidin-3-yl)Methanol;3-HYDROXYMETHYL-N-BENZYL- PYRROLIDINE;1-(Phenylmethyl)-3-pyrrolidinemethanol
CBNumber: CB2194664
Molecular Formula: C12H17NO
Formula Weight: 191.27
MOL File: 5731-17-9.mol

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1-BENZYLPYRROLIDIN-3-YL-METHANOL Property

Boiling point:: 129 °C(Press: 0.9 Torr)
Density: 1.082±0.06 g/cm3(Predicted)
storage temp.: Store at room temperature
form: solid
pka: 14.93±0.10(Predicted)
Appearance: Light yellow to yellow Viscous liquid
InChI: InChI=1S/C12H17NO/c14-10-12-6-7-13(9-12)8-11-4-2-1-3-5-11/h1-5,12,14H,6-10H2
InChIKey: QPQQBJDSKDWQMJ-UHFFFAOYSA-N
SMILES: N1(CC2=CC=CC=C2)CCC(CO)C1
CAS DataBase Reference: 5731-17-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000012
Product name: 1-Benzylpyrrolidin-3-yl-methanol
Purity: Aldrich
Packaging: 1g
Price: $179
Updated: 2025/07/31

TRC

Product number: B289065
Product name: (1-Benzylpyrrolidin-3-yl)methanol
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 018164
Product name: 1-Benzylpyrrolidin-3-yl-methanol
Packaging: 1g
Price: $37
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50914
Product name: 1-Benzylpyrrolidin-3-yl-methanol
Packaging: 250mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB50914
Product name: 1-Benzylpyrrolidin-3-yl-methanol
Packaging: 500mg
Price: $100
Updated: 2021/12/16

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1-BENZYLPYRROLIDIN-3-YL-METHANOL Chemical Properties,Usage,Production

Synthesis

51535-00-3

5731-17-9

Example A: Synthesis of N-benzyl-3-hydroxymethylpyrrolidine Step a: Reduction of methyl 1-benzyl-5-oxopyrrolidine-3-carboxylate to 1-benzyl-3-hydroxymethylpyrrolidine Under an inert atmosphere, methyl 1-benzyl-5-oxopyrrolidine-3-carboxylate (1.0 equiv, commercially available) was dissolved in toluene and the mixture was cooled to 0 °C. To the cooled mixture was slowly added a dimethyl sulfide solution of borane-dimethyl sulfide complex (3.75 equiv.). The reaction mixture was heated to 100°C-110°C and refluxed for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature, further cooled to -5 °C to -10 °C, and then sodium bicarbonate solution was added dropwise. The mixture was slowly warmed to room temperature and then refluxed for 2 hours. After the reaction mixture was cooled, the organic layer was separated and the aqueous layer was extracted with toluene. The combined toluene layers were washed sequentially with water and brine. Finally, the organic solvent was removed by evaporation under reduced pressure to afford the target product N-benzyl-3-hydroxymethylpyrrolidine in 99.14% yield.

References

[1] Patent: WO2006/18708, 2006, A2. Location in patent: Page/Page column 21-22
[2] Letters in Organic Chemistry, 2011, vol. 8, # 3, p. 155 - 162
[3] Patent: US2004/147502, 2004, A1. Location in patent: Page/Page column 36-37
[4] Organic Letters, 1999, vol. 1, # 5, p. 799 - 801
[5] Patent: US2005/165005, 2005, A1. Location in patent: Page/Page column 59-60

1-BENZYLPYRROLIDIN-3-YL-METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BENZYLPYRROLIDIN-3-YL-METHANOL Suppliers

Canada 1 China 109 Germany 2 India 2 United Kingdom 2 United States 20 Global 136

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View Lastest Price from 1-BENZYLPYRROLIDIN-3-YL-METHANOL manufacturers

Career Henan Chemical Co

Product: 1-BENZYLPYRROLIDIN-3-YL-METHANOL 5731-17-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

Career Henan Chemical Co

Product: 1-BENZYLPYRROLIDIN-3-YL-METHANOL 5731-17-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-25

5731-17-9, 1-BENZYLPYRROLIDIN-3-YL-METHANOLRelated Search:

Octazamide 3-Hydroxymethylpyrrolidine 1-BENZYLPYRROLE 1-(4-METHYL-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID Methyl 1-Benzyl-5-oxopyrrolidine-3-carboxylate 1-(4-FLUOROBENZYL)-5-OXO-3-PYRROLIDINECARBOXYLIC ACID 1-(4-CHLOROBENZYL)-5-OXOPYRROLIDINE-3-CARBOXYLIC ACID Ethyl 1-(4-methoxybenzoyl)-2-oxo-4-phenyl-3-pyrrolidinecarboxylate 5-OXO-1-(1-PHENYL-ETHYL)-PYRROLIDINE-3-CARBOXYLIC ACID 5-OXO-1-[4-(TRIFLUOROMETHYL)BENZYL]PYRROLIDINE-3-CARBOXYLIC ACID (1'R, 3R)-1-(1'-PHENYLETHYL)-5-OXO-3-PYRROLIDINE CARBOXYLIC ACID 1-(2-METHOXY-BENZYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 1-(2-CHLOROBENZYL)-5-OXOPYRROLIDINE-3-CARBOXYLIC ACID 1-BENZYL-2-(4-METHOXY-PHENYL)-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACID 1-BENZYL-5-OXO-3-PYRROLIDINECARBOXYLIC ACID 4-BENZYL-10-OXA-4-AZATRICYCLO[5.2.1.0(2,6)]DEC-8-ENE-3,5-DIONE 1-BENZYL-(2R,4R)-4-AMINO-PYRROLIDINE-2,4-DICARBOXYLIC ACID HCL 1-BENZYL-5-OXO-2-PHENYL-PYRROLIDINE-3-CARBOXYLIC ACID

1-BENZYL-3-HYDROXYMETHYLPYRROLIDINE

1-BENZYL-3-PYRROLIDIN-3-YLMETHANOL

CHEMBRDG-BB 4003810

3-Pyrrolidinemethanol, 1-(phenylmethyl)-

3-HYDROXYMETHYL-N-BENZYL- PYRROLIDINE

1-BENZYL-DL-BETA-PROLINOL

1-Benzyl-3-pyrrolidinemethanol

1-(Phenylmethyl)-3-pyrrolidinemethanol

(1-benzylpyrrolidin-3-yl)methanol(SALTDATA: FREE)

1-Benzylpyrrolidine-3-methanol

(1-Benzyl-1H-pyrrolidin-3-yl)Methanol

1-Benzyl-1H-pyrrolidin-3-yl-Methanol

1-Benzyl-3-hydroxyMethyl-1H-pyrrolidine

(1-Benzylpyrrolidin-3-yl)methanol hydrochloride

1-benzyl-DL-beta-prolinol, CAS 5731-17-9

5731-17-9

API intermediates

pharmacetical

Pyrrole&Pyrrolidine&Pyrroline