(GLY14)-HUMANIN (HUMAN)

Product Name: (GLY14)-HUMANIN (HUMAN)
CAS No.: 330936-70-4
Chemical Name: (GLY14)-HUMANIN (HUMAN)
Synonyms: HNG;MAPRGFSCLLLLTGEIDLPVKRRA;SHNG;[GLY14]-HN;[GLY14]-HUMANIN;[Gly14]Humanin (1);[Gly14]-Humanin G human;MAPGSGCLLLLTGEIDLPVKRRA;(GLY14)-HUMANIN (HUMAN);(Gly??)-Humanin (human)
CBNumber: CB2195681
Molecular Formula: C118H202N34O31S2
Formula Weight: 2657.21
MOL File: 330936-70-4.mol

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(GLY14)-HUMANIN (HUMAN) Property

storage temp.: −70°C
form: solid
color: White to off-white
biological source: human
Water Solubility: water: 1.00-1.04mg/mL, clear, colorless
InChIKey: WUYRHUFIUFJVQU-LIRFXKSTNA-N

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd

Product number: orb364086
Product name: [Gly14]-Humanin
Purity: > 95%
Packaging: 1mg
Price: $552.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb364086
Product name: [Gly14]-Humanin
Purity: > 95%
Packaging: 5mg
Price: $1174.7
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb364086
Product name: [Gly14]-Humanin
Purity: > 95%
Packaging: 10mg
Price: $1756.1
Updated: 2021/12/16

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(GLY14)-HUMANIN (HUMAN) Chemical Properties,Usage,Production

Uses

[Gly14]-Humanin G human has been used:

along with bortezomib in pharmacological inhibition studies to tre at mice to limit the toxic effects of bortezomib
to study its effect on high glucose (HG)-induced apoptosis of endothelial cells (ECs)
to study its neuroprotective effects in an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) model using SH-SY5Y neuroblastoma cells

', '[Gly1?]-Humanin G human has been used to limit the toxicity during the bortezomib treatment in neonatal brachial plexus injury (NBPI) mice model. It has also been used in the cell culture of the human-derived neuroblastoma cell line.

Biological Activity

Endogenous rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimerμs disease genes and Aβ', '[Gly14]-humanin (HNG) stimulates cell growth, proliferation, and cell cycle progression. It enhances proteins such as kinases, transporters, transmembrane receptors, and transcription and translational regulators. HNG exhibits intense in vitro neuroprotective effects compared to natural HN. Studies show th at it is an effective cytoprotectant both in vitro and in vivo. HNG is found to prevent high glucose (HG)-induced apoptosis of endothelial cells (ECs). It is proven to inhibit AngII-induced phenotypic switch in vascular smooth muscle cells (VSMCs).

in vivo

(Gly14)-Humanin (human) (0.1 μg/5 μL; i.c.v.; once) decreases cells with plasmalemma permeability in the injured cortex and hippocampus, reduces brain lesion volume, improves motor performance and ameliorates performance in the Morris water maze test^[2].

Animal Model:	Adult male CD-1 mice (25-30 g; 10-12-week-old) bearing traumatic brain injury (TBI)^[2]
Dosage:	0.1 μg/5 μL
Administration:	Intracerebroventricularly (i.c.v.); once
Result:	Decreased cells with plasmalemma permeability in the injured cortex and hippocampus, reduced brain lesion volume, improved motor performance.

(GLY14)-HUMANIN (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

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(GLY14)-HUMANIN (HUMAN) Suppliers

China 67 France 1 Japan 2 Switzerland 1 The Netherlands 1 United States 6 Global 78

Brunschwig chemie

Tel: --
Fax: --
Email: brunschwig@brunschwig.nl
Country: The Netherlands
ProdList: 4996
Advantage: 67

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View Lastest Price from (GLY14)-HUMANIN (HUMAN) manufacturers

Career Henan Chemical Co

Product: (GLY14)-HUMANIN (HUMAN) 330936-70-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-02-16

330936-70-4, (GLY14)-HUMANIN (HUMAN)Related Search:

BIOTIN-LC-EPQ-PY-EEIPIYL AC-ASP-TYR(PO3H2)-VAL-PRO-MET-LEU-NH2 BIOTIN-LC-PTYR-GLU-GLU-ILE-OH EPQ-PY-EEIPIYL* AC-PTYR-PTYR-PTYR-ILE-GLU-OH GLY-PHE-SER L-Leu-Leu-Leu [125I]-HUMANIN (HUMAN) HUMANIN TRIFLUOROACETATE (GLY14)-HUMANIN (HUMAN)

MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA

MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA TRIFLUOROACETATE

MAPRGFSCLLLLTGEIDLPVKRRA

H-MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA-OH

MAPGSGCLLLLTGEIDLPVKRRA

[GLY14]-HN

[GLY14]-HUMANIN

[GLY14] HUMANIN G (HNG), HUMAN

(GLY14)-HUMANIN (HUMAN)

[GLY14]-HUMANIN TRIFLUOROACETATE

[Gly14]-Humanin G human

HNG

SHNG

[Gly14]Humanin (1)

MET-ALA-PRO-ARG-GLY-PHE-SER-CYS-LEU-LEU-LEU-LEU-THR-GLY-GLU-ILE-ASP-LEU-PRO-VAL-LYS-ARG-ARG-ALA: MAPRGFSCLLLLTGEIDLPVKRRA

sHNG, [Gly14] - HN, [Gly14] – Humanin

L-Alanine, L-methionyl-L-alanyl-L-prolyl-L-arginylglycyl-L-phenylalanyl-L-seryl-L-cysteinyl-L-leucyl-L-leucyl-L-leucyl-L-leucyl-L-threonylglycyl-L-α-glutamyl-L-isoleucyl-L-α-aspartyl-L-leucyl-L-prolyl-L-valyl-L-lysyl-L-arginyl-L-arginyl-

GLY14-Humanin(human) acetate

Humanin-G(human) acetate

(Gly??)-Humanin (human)

Humanin S14G, sHNG - 1 mg

(Gly14)-Humanin (human) trifluoroacetate salt

330936-70-4

C118H202N34O31S2

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