ChemicalBook > CAS DataBase List > 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]

4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]

Product Name: 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]
CAS No.: 27470-51-5
Chemical Name: 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]
Synonyms: ae-17;flogos;alfide;solurol;Aflogan;Calibene;SUXIBUZONE;Suxibuzona;lidinedione;Suxibuzonum
CBNumber: CB2196749
Molecular Formula: C24H26N2O6
Formula Weight: 438.47
MOL File: 27470-51-5.mol

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4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Property

Melting point:: 126-127°
Boiling point:: 550.33°C (rough estimate)
Density: 1.2847 (rough estimate)
refractive index: 1.6300 (estimate)
storage temp.: 2-8°C
solubility: Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent), practically insoluble in cyclohexane.
pka: 4.33±0.17(Predicted)
form: Solid
color: White to Off-White
CAS DataBase Reference: 27470-51-5

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36
WGK Germany: 3
RTECS: WM9640000
Toxicity: LD50 orally in mice: 5.683 micromol/kg (Esteve, 1973)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S2400000
Product name: Suxibuzone
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 50 mg
Price: $225
Updated: 2025/07/31

Sigma-Aldrich

Product number: S2400000
Product name: Suxibuzone
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: s2400000
Price: $220
Updated: 2024/03/01

TRC

Product number: S880000
Product name: Suxibuzone
Packaging: 100mg
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: X6836
Product name: Suxibuzone
Packaging: 100mg
Price: $89
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008442
Product name: SUXIBUZONE
Purity: 95.00%
Packaging: 100MG
Price: $238.35
Updated: 2021/12/16

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4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

analgesic, antipyretic, antiinflammatory

Uses

Suxibuzone is a prodrug of the non steroidal anti inflammatory drug phenylbutazone. It is a drug used for joint and muscular pain.

Definition

ChEBI: A pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses.

brand name

Calibene;Danalon om;Danilon;Flamilon;Flofos.

World Health Organization (WHO)

Suxibuzone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1974 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone, it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.

Biochem/physiol Actions

A prodrug of phenylbutazone.

4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Preparation Products And Raw materials

Raw materials

Preparation Products

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27470-51-5, 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]Related Search:

3-METHOXYPROPIONIC ACID HYDRAZIDE 4,4-Dimethyl-1-phenyl-3-pyrazolidone 1-Acetyl-2-phenylhydrazine MOFEBUTAZONE 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Dimezone S 3-AMINO-2,2-DIMETHYL-1-PROPANOL 1,2-Diphenylhydrazine Phenylbutazone Phenidone 1-Phenyl-4-methyl-3-pyrazolidone 2,2-Dimethylpropionic acid hydrazide 1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE 2,2,2-TRIMETHYLACETANILIDE 3-METHOXY-2,2-DIMETHYLPROPYLAMINE MALONANILIDE N-PHENYL-N'-PROPIONYLHYDRAZINE 2,2-dimethyl-3-(methylamino)propan-1-ol

4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]

4-butyl-4-(beta-carboxypropionyl-oxymethyl)-1,2-diphenyl-3,5-pyrazolidinedio

4-butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedionehydrogensuccinate

ae-17

alfide

SUXIBUZONE

Acetanilide Impurity 1

butanedioicacid,mono((4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl

flogos

lidinedione

solurol

succinicacid,monoesterwith4-butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazo

3-(1,2-Diphenyl-3,5-dioxo-4-butylpyrazolidine-4-ylmethoxycarbonyl)propionic acid

Succinic acid hydrogen (1,2-diphenyl-3,5-dioxo-4-butylpyrazolidin-4-yl)methyl ester

Succinic acid hydrogen (4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl ester

Succinic acid hydrogen 1-[(4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl] ester

3-((4-Butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methoxycarbonyl)propionsaeure

3,5-Pyrazolidinedione, 4-butyl-4-(hydroxymethyl)-1,2-diphenyl-, hydrogen succinate (ester)

4-Butyl-4-(beta-carboxypropionyl-oxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione

4-Hydroxymethylbutazolidine hemisuccinate

Aflogan

Suxibuzone CRS

Butanedioic acid, 1-[(4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl] ester

4-((4-butyl-3,5-dioxo-1,2-diphenylpyrazolidin-4-yl)methoxy)-4-oxobutanoic acid

Calibene

Suxibuzona

Suxibuzonum

Inhibitor,Suxibuzone,inhibit

1-[3-[2-(dimethylamino)ethyl]-1-[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]-1H-indol-5-yl]-N-methylmethanesulfon amide

Suxibuzone, 10 mM in DMSO

27470-51-5

Biochemicals and Reagents

BioChemical

Substrate Analogs

Enzyme Inhibitors by Type

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

DANILON