MOFEBUTAZONE
- Product Name
- MOFEBUTAZONE
- CAS No.
- 2210-63-1
- Chemical Name
- MOFEBUTAZONE
- Synonyms
- 2fdbp;monazan;mobuzon;reumatox;monobutyl;mobutazon;MOFEBUTAZONE;monorheumetten;arcomonoltablets;monophenylbutazone
- CBNumber
- CB0667894
- Molecular Formula
- C13H16N2O2
- Formula Weight
- 232.28
- MOL File
- 2210-63-1.mol
MOFEBUTAZONE Property
- Melting point:
- 102-103°
- Boiling point:
- 374.44°C (rough estimate)
- Density
- 1.1099 (rough estimate)
- refractive index
- 1.6450 (estimate)
- storage temp.
- Room Temperature
- solubility
- DMSO (Slightly), Methanol (Sparingly)
- form
- Solid
- pka
- 5.22±0.10(Predicted)
- color
- White to Off-White
Safety
- Toxicity
- LD50 i.v. in mice: 600 mg/kg (Schoetensack)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M485400
- Product name
- Mofebutazone
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- M485400
- Product name
- Mofebutazone
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- API0010057
- Product name
- MOFEBUTAZONE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $721.88
- Updated
- 2021/12/16
- Product number
- API0010057
- Product name
- MOFEBUTAZONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1080.45
- Updated
- 2021/12/16
- Product number
- 52412
- Product name
- Mofebutazone
- Packaging
- 10g
- Price
- $1250
- Updated
- 2021/12/16
MOFEBUTAZONE Chemical Properties,Usage,Production
Originator
Butaphen,Wiedenmann
Uses
Mofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.
Definition
ChEBI: A pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain.
Manufacturing Process
A mixture comprising 108 g of phenyl hydrazine and 216 g of the diethyl ester of n-butylmalonic acid is heated on an oil bath at 170°-180°C for 12 hours. The residue is taken up with water in which an alkaline compound has been dissolved and acetic acid is added to precipitate 4-n-butyl-2-phenylpyrazolidine-3,5-dione. The product is a white crystalline solid having a MP: 103°C. It is soluble in acetone and benzene, soluble in hot condition in methanol and ethanol and insoluble in water.
brand name
Arcobutine;Buta lyseen;Chemiartrol;Clinit;Diadin;Fenartril;Jovapyrin;Mobutazone;Mofasal;Mofesal;Monazone;Monbutina;Monobutina;Monofen;Monomil;Monoprine;Monozon;Mozol;Rheuma-cur;Rheumaorctat;Rivodol;Sodepyrine b 1.
Therapeutic Function
Antirheumatic, Analgesic, Antiinflammatory
World Health Organization (WHO)
Mofebutazone, a pyrazolone with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1962 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.
Clinical Use
Mofebutazone is a nonsteroidal anti-inflammatory drug used as sodium salt for the treatment of mild to moderate pain including inflammatory and degenerative rheumatic disorders and musculoskeletal pain. Mofebutazone can be given by oral, rectal (900–1200 mg/d), or intramuscular administration (650 mg/d).
MOFEBUTAZONE Preparation Products And Raw materials
Raw materials
Preparation Products
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