MOFEBUTAZONE Property

Melting point:

102-103°

Boiling point:

374.44°C (rough estimate)

Density 

1.1099 (rough estimate)

refractive index 

1.6450 (estimate)

storage temp. 

Room Temperature

solubility 

DMSO (Slightly), Methanol (Sparingly)

form 

Solid

pka

5.22±0.10(Predicted)

color 

White to Off-White

Safety

Toxicity

LD50 i.v. in mice: 600 mg/kg (Schoetensack)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

MOFEBUTAZONE Chemical Properties,Usage,Production

Originator

Butaphen,Wiedenmann

Uses

Mofebutazone is an anti-inflammatory drug used on the gastrointestinal and renal tissues.

Definition

ChEBI: A pyrazolidine that is phenylbutazone lacking one of the phenyl substituents. It is used for treatment of joint and muscular pain.

Manufacturing Process

A mixture comprising 108 g of phenyl hydrazine and 216 g of the diethyl ester of n-butylmalonic acid is heated on an oil bath at 170°-180°C for 12 hours. The residue is taken up with water in which an alkaline compound has been dissolved and acetic acid is added to precipitate 4-n-butyl-2-phenylpyrazolidine-3,5-dione. The product is a white crystalline solid having a MP: 103°C. It is soluble in acetone and benzene, soluble in hot condition in methanol and ethanol and insoluble in water.

brand name

Arcobutine;Buta lyseen;Chemiartrol;Clinit;Diadin;Fenartril;Jovapyrin;Mobutazone;Mofasal;Mofesal;Monazone;Monbutina;Monobutina;Monofen;Monomil;Monoprine;Monozon;Mozol;Rheuma-cur;Rheumaorctat;Rivodol;Sodepyrine b 1.

Therapeutic Function

Antirheumatic, Analgesic, Antiinflammatory

World Health Organization (WHO)

Mofebutazone, a pyrazolone with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1962 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.

Clinical Use

Mofebutazone is a nonsteroidal anti-inflammatory drug used as sodium salt for the treatment of mild to moderate pain including inflammatory and degenerative rheumatic disorders and musculoskeletal pain. Mofebutazone can be given by oral, rectal (900–1200 mg/d), or intramuscular administration (650 mg/d).