KETOPHENYLBUTAZONE

Product Name: KETOPHENYLBUTAZONE
CAS No.: 853-34-9
Chemical Name: KETOPHENYLBUTAZONE
Synonyms: kpb;Ejor;pecnon;chetil;ketason;Ketanol;Ketazon;chebutan;ketazone;chepirol
CBNumber: CB9485543
Molecular Formula: C19H18N2O3
Formula Weight: 322.36
MOL File: 853-34-9.mol

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KETOPHENYLBUTAZONE Property

Melting point:: 115.5-116.5° or 127.5-128.5° depending on cryst form
Boiling point:: 460.98°C (rough estimate)
Density: 1.2336 (rough estimate)
refractive index: 1.6140 (estimate)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Solid
color: Off-White to Light Yellow
Water Solubility: 174.2mg/L(20 ºC)

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Safety

Toxicity: LD50 oral in rat: 720mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: K155300
Product name: Kebuzone
Packaging: 10mg
Price: $185
Updated: 2021/12/16

Usbiological

Product number: K0140-01
Product name: Kebuzone
Packaging: 500ul
Price: $531
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003082
Product name: KETOPHENYLBUTAZONE
Purity: 95.00%
Packaging: 25MG
Price: $750.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003082
Product name: KETOPHENYLBUTAZONE
Purity: 95.00%
Packaging: 1G
Price: $1379.7
Updated: 2021/12/16

Alichem

Product number: 853349
Product name: 4-(3-Oxobutyl)-1,2-diphenylpyrazolidine-3,5-dione
Packaging: 1g
Price: $544
Updated: 2021/12/16

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KETOPHENYLBUTAZONE Chemical Properties,Usage,Production

Originator

Chebutan,Bioindustria,Italy,1961

Uses

Antirheumatic.

Definition

ChEBI: A pyrazolidine that is phenylbutazone in which the two methylene hydrogens at postion 3 on the butyl chain are replaced by an oxo group.

Manufacturing Process

(a) 3,3-ethylene dioxyburyl malonic acid diethyl ester: Diethylmalonate is reacted with methyl vinyl ketone and the resulting oxobutyl diethylmalonate is reacted with ethylene glycol.
(b) 1,2-diphenyl-4-(3',3'-ethylene dioxybutyl)3,5-dioxopyrazolidine: 274 parts of (3,3-ethylene dioxybutyl)-malonic acid diethyl ester are dissolved in 100 parts by volume of abs. benzene and 57 parts of sodium ethylate and 184 parts of hydrazobenzene are added. Heat is generated. The reaction mass is boiled for 15 hours under reflux. After cooling, it is poured into water, separated and the aqueous part is washed twice with benzene. The benzene solutions are washed three times with 2N sodium carbonate solution and the unified aqueous solutions are acidified with 2N hydrochloric acid. The 1,2- phenyl-4-(3',3'-ethylene dioxybutyl)-3,5-dioxopyrazolidine which precipitates can be recrystallized from alcohol. Melting point 165°C to 167°C.
(c) 1,2-diphenyl-4-(3'-oxobutyl)-3,5-dioxopyrazolidine: 36.6 parts of 1,2- diphenyl-4-(3',3'-ethylene dioxybutyl)-3,5-dioxopyrazolidine in 750 parts byvolume of acetone are boiled under reflux for 18 hours with 0.35 part of ptoluene sulfonic acid. The solution is then filtered, 1,500 parts of water are added and the whole is allowed to stand for 24 hours at 5°C. The 1,2- diphenyl-4-(3'-oxobutyl)-3,5-dioxopyrazolidine which precipitates is filtered off under suction and washed with 50% acetone. Melting point from alcohol/water mixture: 115.5°C to 116.5°C. Sometimes a crystal form is obtained which melts at 127.5°C to 128.5°C.

brand name

Benjor;Chebutan;Chepirol;Chetazolidin;Chetosol;Copirene;Gammachetone;Hichillos;Kentan-s;Kenta-s;Kenzon r;Ketobutane-jade;Ketofen;Neo-panalgyl;Neufenil;Neuphenyl;Phloguron;Recheton;Reuchetal;Reumo;Tkb;Vintab;Vintop.

Therapeutic Function

Antirheumatic

World Health Organization (WHO)

Kebuzone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1973 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.

Clinical Use

Kebuzone is a nonsteroidal anti-inflammatory drug used for the treatment of acute and chronic pain and inflammation states like musculoskeletal, joint, and soft-tissue disorders. Kebuzone is administered orally, rectally, or intramuscular (up to 1500 mg/d i

KETOPHENYLBUTAZONE Preparation Products And Raw materials

Raw materials

Preparation Products

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KETOPHENYLBUTAZONE Suppliers

Canada 1 China 38 Europe 1 Germany 1 India 1 United Kingdom 1 United States 5 Global 48

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2127
Advantage: 70

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Aikon International Limited

Tel: 025-66113011 18112977050
Fax: (5)02557626880
Email: cb6@aikonchem.com
Country: China
ProdList: 15495
Advantage: 58

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3242
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55896
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: CHINA
ProdList: 52867
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 4008210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 55023
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

853-34-9, KETOPHENYLBUTAZONERelated Search:

Phenylbutazone N-PHENYL-N'-PROPIONYLHYDRAZINE MOFEBUTAZONE tribuzone 1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE benzopyrazone 1,2-Diphenylhydrazine Phenidone 1-Phenyl-4-methyl-3-pyrazolidone Benzoic acid, 2-(acetyloxy)-, (4-(4,4-dimethyl-3-oxopentyl)-3,5-dioxo- 1,2-diphenyl-4-pyrazolidinyl)methyl ester KETOPHENYLBUTAZONE

keobutane-jade

ketason

ketazone

kpb

pecnon

KETOPHENYLBUTAZONE

1,2-diphenyl-4-(3’-oxobutyl)-3,5-dioxopyrazolidine

1,2-diphenyl-4-(3-oxobutyl)-5-pyrazolidinedione

1,2-diphenyl-4-(gamma-ketobutyl)-3,5-pyrazolidinedione

4-(3-oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione

chebutan

chepirol

chetazolidin

chetil

copirene

gamma-ketophenylbutazone

hichillos

kebuzone

4-(3-Oxobutyl)-1,2-diphenyl-

Chetazol

Chetopir

4-(3-ketobutyl)-1,2-di(phenyl)pyrazolidine-3,5-quinone

4-(3-oxobutyl)-1,2-di(phenyl)pyrazolidine-3,5-dione

1,2-Diphenyl-4-(2-acetylethyl)pyrazolidine-3,5-dione

3,5-Pyrazolidinedione,4-(3-oxobutyl)-1,2-diphenyl-

Ejor

Gammachetone

Ketanol

Ketazon

RN 0308507

853-34-9

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals