KETOPHENYLBUTAZONE
- Product Name
- KETOPHENYLBUTAZONE
- CAS No.
- 853-34-9
- Chemical Name
- KETOPHENYLBUTAZONE
- Synonyms
- kpb;Ejor;pecnon;chetil;ketason;Ketanol;Ketazon;chebutan;ketazone;chepirol
- CBNumber
- CB9485543
- Molecular Formula
- C19H18N2O3
- Formula Weight
- 322.36
- MOL File
- 853-34-9.mol
KETOPHENYLBUTAZONE Property
- Melting point:
- 115.5-116.5° or 127.5-128.5° depending on cryst form
- Boiling point:
- 460.98°C (rough estimate)
- Density
- 1.2336 (rough estimate)
- refractive index
- 1.6140 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Light Yellow
- Water Solubility
- 174.2mg/L(20 ºC)
Safety
- Toxicity
- LD50 oral in rat: 720mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- K155300
- Product name
- Kebuzone
- Packaging
- 10mg
- Price
- $185
- Updated
- 2021/12/16
- Product number
- K0140-01
- Product name
- Kebuzone
- Packaging
- 500ul
- Price
- $531
- Updated
- 2021/12/16
- Product number
- API0003082
- Product name
- KETOPHENYLBUTAZONE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $750.75
- Updated
- 2021/12/16
- Product number
- API0003082
- Product name
- KETOPHENYLBUTAZONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1379.7
- Updated
- 2021/12/16
- Product number
- 853349
- Product name
- 4-(3-Oxobutyl)-1,2-diphenylpyrazolidine-3,5-dione
- Packaging
- 1g
- Price
- $544
- Updated
- 2021/12/16
KETOPHENYLBUTAZONE Chemical Properties,Usage,Production
Originator
Chebutan,Bioindustria,Italy,1961
Uses
Antirheumatic.
Definition
ChEBI: A pyrazolidine that is phenylbutazone in which the two methylene hydrogens at postion 3 on the butyl chain are replaced by an oxo group.
Manufacturing Process
(a) 3,3-ethylene dioxyburyl malonic acid diethyl ester: Diethylmalonate is
reacted with methyl vinyl ketone and the resulting oxobutyl diethylmalonate is
reacted with ethylene glycol.
(b) 1,2-diphenyl-4-(3',3'-ethylene dioxybutyl)3,5-dioxopyrazolidine: 274 parts
of (3,3-ethylene dioxybutyl)-malonic acid diethyl ester are dissolved in 100
parts by volume of abs. benzene and 57 parts of sodium ethylate and 184
parts of hydrazobenzene are added. Heat is generated. The reaction mass is
boiled for 15 hours under reflux. After cooling, it is poured into water,
separated and the aqueous part is washed twice with benzene. The benzene
solutions are washed three times with 2N sodium carbonate solution and the
unified aqueous solutions are acidified with 2N hydrochloric acid. The 1,2-
phenyl-4-(3',3'-ethylene dioxybutyl)-3,5-dioxopyrazolidine which precipitates
can be recrystallized from alcohol. Melting point 165°C to 167°C.
(c) 1,2-diphenyl-4-(3'-oxobutyl)-3,5-dioxopyrazolidine: 36.6 parts of 1,2-
diphenyl-4-(3',3'-ethylene dioxybutyl)-3,5-dioxopyrazolidine in 750 parts byvolume of acetone are boiled under reflux for 18 hours with 0.35 part of ptoluene sulfonic acid. The solution is then filtered, 1,500 parts of water are
added and the whole is allowed to stand for 24 hours at 5°C. The 1,2-
diphenyl-4-(3'-oxobutyl)-3,5-dioxopyrazolidine which precipitates is filtered off
under suction and washed with 50% acetone. Melting point from alcohol/water
mixture: 115.5°C to 116.5°C. Sometimes a crystal form is obtained which
melts at 127.5°C to 128.5°C.
brand name
Benjor;Chebutan;Chepirol;Chetazolidin;Chetosol;Copirene;Gammachetone;Hichillos;Kentan-s;Kenta-s;Kenzon r;Ketobutane-jade;Ketofen;Neo-panalgyl;Neufenil;Neuphenyl;Phloguron;Recheton;Reuchetal;Reumo;Tkb;Vintab;Vintop.
Therapeutic Function
Antirheumatic
World Health Organization (WHO)
Kebuzone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1973 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.
Clinical Use
Kebuzone is a nonsteroidal anti-inflammatory drug used for the treatment of acute and chronic pain and inflammation states like musculoskeletal, joint, and soft-tissue disorders. Kebuzone is administered orally, rectally, or intramuscular (up to 1500 mg/d i
KETOPHENYLBUTAZONE Preparation Products And Raw materials
Raw materials
Preparation Products
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