ChemicalBook > CAS DataBase List > CLOFOCTOL
CLOFOCTOL
- Product Name
- CLOFOCTOL
- CAS No.
- 37693-01-9
- Chemical Name
- CLOFOCTOL
- Synonyms
- Octofene;Gramplus;CLOFOCTOL;2-[2,4-DICHLOROBENZYL]-4-[1,1,3,3-TETRAMETHYLBUTYL]PHENOL;α-[2,4-Dichlorophenyl]-4-[1,1,3,3-tetramethylbutyl]-o-cresol;2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethylbutyl)phenol;2-((2,4-dichlorophenyl)methyl)-4-(1,1,3,3-tetramethylbutyl)-pheno;2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol;Phenol, 2-[(2,4-dichlorophenyl)methyl]-4-(1,1,3,3-tetramethylbutyl)-;anticancer,antibacterial,Inhibitor,Antibiotic,prostate cancer,Clofoctol,Bacterial,inhibit,SARS-CoV,SARS coronavirus,antiviral
- CBNumber
- CB2197054
- Molecular Formula
- C21H26Cl2O
- Formula Weight
- 365.34
- MOL File
- 37693-01-9.mol
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CLOFOCTOL Property
- Melting point:
- 78°
- Boiling point:
- 447.7±40.0 °C(Predicted)
- Density
- 1.127±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);273.72(Max Conc. mM)
- form
- Solid
- pka
- 10.09±0.45(Predicted)
- color
- White to off-white
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Safety
- WGK Germany
- 2
- RTECS
- SL0533000
- Toxicity
- LD50 orally in male rats: >4 g/kg (Debat)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C586943
- Product name
- Clofoctol
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
TRC
- Product number
- C586943
- Product name
- Clofoctol
- Packaging
- 2.5g
- Price
- $85
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- API0016253
- Product name
- CLOFOCTOL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.18
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-4755
- Product name
- Clofoctol
- Purity
- 99.93%
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
Crysdot
- Product number
- CD31002050
- Product name
- Clofoctol
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
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CLOFOCTOL Chemical Properties,Usage,Production
Originator
Octofene,Debat,France,1978
Uses
antibacterial
Uses
Clofoctol is a bacteriostatic antibiotic used against gram-positive bacteria.
Definition
ChEBI: 2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol is a diarylmethane.
Manufacturing Process
The following were introduced into a 1 liter flask provided with a reflux
condenser: 206 g (1 mol) of p-(1,1,3,3-tetramethylbutyl)-phenol, 147 g (0.75
mol) of 2,4-dichlorobenzyl chloride, 27 g (0.2 mol) of pure melted zinc
chloride, and 750 ml of anhydrous chloroform.
The mixture was heated to reflux for 24 hours. The chloroformic reaction
mixture was washed with water, and then dried over anhydrous sodium
sulfate. The chloroform was evaporated off and the oil obtained was
fractionally distilled under a pressure of 0.2 mm Hg. The fraction distilling at
140°C to 160°C, being the desired product indicated above, was collected and
crystallized. Yield: 94 g (32% of theory); MP 78°C (after recrystallization in
petroleum ether).
Therapeutic Function
Antiinfective, Bacteriostatic
CLOFOCTOL Preparation Products And Raw materials
Raw materials
Preparation Products
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