4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID

Product Name: 4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID
CAS No.: 2510-32-9
Chemical Name: 4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID
Synonyms: 4-Methyl-oxazol-5-carboxylic acid;4-METHYL-5-OXAZOLECARBOXYLIC ACID;4-METHYL-OXAZOLE-5-CARBOXYLIC ACID;4-Methoxyoxazole-5-carboxylic acid;5-Oxazolecarboxylic acid, 4-Methyl-;4-Methyloxazole-5-carboxylicAcid>4-Methyloxazole-5-carboxylic acid 97%;4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID;4-Methyl-1,3-oxazole-5-carboxylic acid 95%;4-Methyl-1,3-oxazole-5-carboxylic acid ,97%
CBNumber: CB2197690
Molecular Formula: C5H5NO3
Formula Weight: 127.1
MOL File: 2510-32-9.mol

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4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID Property

Melting point:: 239 °C
Boiling point:: 267.3±20.0 °C(Predicted)
Density: 1.348±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
form: powder to crystal
pka: 2.09±0.31(Predicted)
color: White to Gray to Brown
InChIKey: ZIXUNDOOBLSXPE-UHFFFAOYSA-N
CAS DataBase Reference: 2510-32-9

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-36/37/38
Safety Statements: 22-26-36/37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 673692
Product name: 4-Methyloxazole-5-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $149
Updated: 2023/06/20

TCI Chemical

Product number: M2663
Product name: 4-Methyloxazole-5-carboxylic Acid
Purity: >98.0%(T)
Packaging: 1g
Price: $345
Updated: 2024/03/01

TCI Chemical

Product number: M2663
Product name: 4-Methyloxazole-5-carboxylic Acid
Purity: >98.0%(T)
Packaging: 200mg
Price: $115
Updated: 2025/07/31

TRC

Product number: M266295
Product name: 4-Methoxyoxazole-5-carboxylicAcid
Packaging: 1g
Price: $120
Updated: 2021/12/16

TRC

Product number: M266295
Product name: 4-Methoxyoxazole-5-carboxylicAcid
Packaging: 25g
Price: $1625
Updated: 2021/12/16

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4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to tan solid

Uses

4-Methoxyoxazole-5-carboxylic Acid is used in the synthesis of highly selective α4β2-Nicotinic acetylcholine receptor agonists used in the treatment of cognitive disorders. It is also used in the synthesis of small molecule human FPR1 receptor antagonists.

Uses

Used in a palladium-catalyzed cross-coupling between heteroaryl carboxylic acids and aryl bromides leading to arylated heterocycles.

Synthesis

77287-34-4

609-15-4

2510-32-9

The general procedure for the synthesis of 4-methyl-1,3-oxazole-5-carboxylic acid from the compound (CAS:77287-34-4) and ethyl 2-chloroacetoacetate is as follows: 1. ethyl 2-chloroacetoacetate (1 wt., 1 eq., 1000 g) was mixed with formamide (0.68 v/v, ca. 2.8 eq.), and the resulting solution was heated to 120° C. The reaction was carried out as follows. 2. After 5 hours of reaction, the mixture was cooled to room temperature and allowed to stand overnight under nitrogen protection. 3. the mixture was treated with 3M NaOH aqueous solution (6 vol.), the reaction was moderately exothermic and stirred for 4 hours at room temperature. 4. Add ethyl acetate (6 v/v) and separate the two phases. The organic layer was discarded and the aqueous phase was adjusted to pH 2 with 32% aqueous HCl (about 2.0 vol. portions required), at which point a precipitate began to form. 5. The suspension was treated with ethyl acetate (8 v/v) with vigorous stirring until most of the precipitate was dissolved. 6. The aqueous phase was further extracted twice with ethyl acetate (6 vol. parts each), the organic layers were combined and distilled to a small volume (the suspension was observed to reappear). 7. Fresh ethyl acetate (8 vol. parts) was added and the mixture was evaporated to dryness. 8. The collected solid was dried under reduced pressure at 40 °C overnight to afford 4-methyl-1,3-oxazole-5-carboxylic acid (498 g, 64.5% yield).

References

[1] Patent: WO2005/80382, 2005, A1. Location in patent: Page/Page column 47-48
[2] Patent: WO2007/22933, 2007, A1. Location in patent: Page/Page column 31-32
[3] Patent: WO2007/22980, 2007, A1. Location in patent: Page/Page column 35; 36
[4] Patent: WO2005/123717, 2005, A1. Location in patent: Page/Page column 21-22
[5] Patent: WO2006/108700, 2006, A1. Location in patent: Page/Page column 34-35

4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Ammonium formate Potassium carbonate Formic acid Diethyl ether Ethyl acetate Hydrochloric acid Sodium hydroxide Ethyl 2-chloroacetoacetate

Preparation Products

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4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID Suppliers

Americas 1 Belgium 2 China 110 Europe 1 Germany 6 India 5 Japan 3 Poland 1 Switzerland 1 United Kingdom 7 United States 32 Global 169

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View Lastest Price from 4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: 4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID 2510-32-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 Tons
Release date: 2020-01-03

2510-32-9, 4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACIDRelated Search:

Ethyl 4-methyl-1,3-oxazole-5-carboxylate 4-METHYLOXAZOLE-5-METHANOL 4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID 2-METHYL-1,3-OXAZOLE-4-CARBOXYLIC ACID 5-(2-METHYL-4-BROMOPHENYL)-OXAZOLE-4-CARBOXYLIC ACID 5-METHYL-1,3-OXAZOLE-4-CARBOXYLIC ACID OXAZOLE-5-CARBOXYLIC ACID 2-AMINO-4-TRIFLUOROMETHYL-OXAZOLE-5-CARBOXYLIC ACID ETHYL ESTER METHYL 4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-OXAZOLE-5-CARBOXYLATE ETHYL 2,4-DIMETHYLOXAZOLE-5-CARBOXYLATE ETHYL-2-CHLORO-4-(TRIFLUOROMETHYL)OXAZOLE-5-CARBOXYLATE METHYL 4-BENZYL-2-PHENYLOXAZOLE-5-CARBOXYLATE 2,4-dimethyl-1,3-oxazole-5-carboxylic acid 4-METHYL-2-PHENYL-1,3-OXAZOLE-5-CARBOXYLIC ACID METHYL 4-METHYL-2-PHENYL-1,3-OXAZOLE-5-CARBOXYLATE 5-methyl-1,2-oxazole-3-carboxylic acid 2-METHYL-5-(TRIFLUOROMETHYL)OXAZOLE-4-CARBOXYLIC ACID 2-(4-METHOXYPHENYL)-5-METHYL-1,3-OXAZOLE-4-CARBOXYLIC ACID

4-METHYL-5-OXAZOLECARBOXYLIC ACID

4-METHYL-OXAZOLE-5-CARBOXYLIC ACID

4-METHYL-1,3-OXAZOLE-5-CARBOXYLIC ACID

4-methyl-1,3-oxazole-5-carboxylic acid(SALTDATA: FREE)

4-Methyl-1,3-oxazole-5-carboxylic acid ,97%

4-Methyl-1,3-oxazole-5-carboxylic acid 95%

5-Oxazolecarboxylic acid, 4-Methyl-

4-Methyl-oxazol-5-carboxylic acid

4-Methoxyoxazole-5-carboxylic acid

4-Methyloxazole-5-carboxylic acid 97%

4-Methyloxazole-5-carboxylicAcid&gt

2510-32-9

Building Blocks

Oxazoles

Heterocyclic Building Blocks

Carboxylic Acids

Oxazoles, Isoxazoles & Benzoxazoles

Heterocyclic Compounds

Carboxylic Acids

Oxazoles, Isoxazoles & Benzoxazoles

Building Blocks

Heterocyclic Building Blocks

Oxazoles