OXAZOLE-5-CARBOXYLIC ACID

Product Name: OXAZOLE-5-CARBOXYLIC ACID
CAS No.: 118994-90-4
Chemical Name: OXAZOLE-5-CARBOXYLIC ACID
Synonyms: 5-Carboxy-1,3-oxazole;oxazol-5-carboxylic acid;5-OXAZOLECARBOXYLIC ACID;OXAZOLE-5-CARBOXYLIC ACID;5-Oxazolecarboxylicacid(9CI);1,3-Oxazole-5-carboxylic acid;Oxazole-5-carboxylic acid, 98+;1,3-Oxazole-5-carboxylic acid 98%;5-Oxazolecarboxylic acid (9CI, ACI)
CBNumber: CB4105709
Molecular Formula: C4H3NO3
Formula Weight: 113.07
MOL File: 118994-90-4.mol

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OXAZOLE-5-CARBOXYLIC ACID Property

Melting point:: 195-197
Boiling point:: 289.3±13.0 °C(Predicted)
Density: 1.449±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: solid
pka: 2.39±0.10(Predicted)
color: Off-white to brown
Water Solubility: Soluble in water.
InChIKey: QCGMEWVZBGQOFN-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 722111
Product name: 5-Oxazolecarboxylic acid
Purity: 97%
Packaging: 500mg
Price: $117
Updated: 2023/06/20

TCI Chemical

Product number: O0602
Product name: Oxazole-5-carboxylic Acid
Purity: min. 95.0 %
Packaging: 1G
Price: $73
Updated: 2025/07/31

TCI Chemical

Product number: O0602
Product name: Oxazole-5-carboxylic Acid
Purity: min. 95.0 %
Packaging: 5G
Price: $221
Updated: 2025/07/31

TRC

Product number: O846523
Product name: Oxazole-5-carboxylicAcid
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 082621
Product name: 1,3-Oxazole-5-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $94
Updated: 2021/12/16

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OXAZOLE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

Decarboxylative cross-coupling of thiazole and oxazole-5-carboxylic acids with aryl halides is reported.

Synthesis

118994-89-1

118994-90-4

General procedure for the synthesis of oxazole-5-carboxylic acid from ethyl oxazole-5-carboxylate: an aqueous solution of lithium hydroxide monohydrate (124.5 kg, prepared by dissolving 49.44 kg of lithium hydroxide monohydrate in 319 kg of water, 398 mol) was slowly added to a solution of ethyl oxazole-5-carboxylate (54 kg, 382.7 mol) in water (54 kg), the reaction The temperature was kept below 25°C during the reaction. the reaction mixture was stirred for 6.5 h and then concentrated. Subsequently, an aqueous HCl solution (64.8 kg) was slowly added while keeping the temperature below 25°C. The mixture was cooled to 5°C and maintained for 1 h to promote crystallization. The crystalline product was collected by filtration, washed sequentially with cold water (88 kg) and isopropanol (171 kg) and finally dried under vacuum at 50 °C to give oxazole-5-carboxylic acid (37.88 kg, 87% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 13.68 (br.s, 1H), 8.59 (s, 1H), 7.88 (s, 1H).

References

[1] Patent: WO2016/193255, 2016, A1. Location in patent: Page/Page column 21
[2] Patent: WO2018/29126, 2018, A1. Location in patent: Page/Page column 49

OXAZOLE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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OXAZOLE-5-CARBOXYLIC ACID Suppliers

China 122 Europe 1 India 4 Switzerland 2 United Kingdom 2 United States 22 Global 153

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View Lastest Price from OXAZOLE-5-CARBOXYLIC ACID manufacturers

Career Henan Chemical Co

Product: OXAZOLE-5-CARBOXYLIC ACID 118994-90-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-21

118994-90-4, OXAZOLE-5-CARBOXYLIC ACIDRelated Search:

ETHYL OXAZOLE-5-CARBOXYLATE 1,3-OXAZOLE-4-CARBOXYLIC ACID ETHYL 2-OXAZOLECARBOXYLATE 5-ISOXAZOLEMETHANOL 5-OXAZOLECARBOXALDEHYDE OXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE SodiuM oxazole-2-carboxylate Oxazole-4-carbaldehyde Methyl 5-oxazolecarboxylate Oxazole-2-carbaldehyde OXAZOLE-5-CARBONITRILE 4-Oxazolecarboxylic acid, methyl ester (9CI) 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-oxazole Oxazole-5-acetic Acid Oxazole OXAZOLE-4-CARBOXYLIC ACID HYDRAZIDE OXAZOLE-5-CARBOXYLIC ACID ETHYL 5-METHYLISOXAZOLE-3-CARBOXYLATE

OXAZOLE-5-CARBOXYLIC ACID

1,3-Oxazole-5-carboxylic acid

1,3-Oxazole-5-carboxylic acid 98%

5-Oxazolecarboxylicacid(9CI)

5-OXAZOLECARBOXYLIC ACID

Oxazole-5-carboxylic acid, 98+

5-Carboxy-1,3-oxazole

oxazol-5-carboxylic acid

5-Oxazolecarboxylic acid (9CI, ACI)

118994-90-4

Building Blocks

Oxazole

CARBOXYLICACID

blocks

Oxazoles