5-ISOXAZOLEMETHANOL

Product Name: 5-ISOXAZOLEMETHANOL
CAS No.: 127232-41-1
Chemical Name: 5-ISOXAZOLEMETHANOL
Synonyms: AKOS PAO-1429;5-OxazoleMethanol;5-oxazolylmethanol;OXAZOLE-5-METHANOL;Oxazol-5-ylMethanol;5-ISOXAZOLEMETHANOL;1,3-Oxazol-5-methanol;ISOXAZOL-5-YL-METHANOL;5-hydroxymethyloxazole;1,3-Oxazol-5-ylmethanol
CBNumber: CB2720856
Molecular Formula: C4H5NO2
Formula Weight: 99.09
MOL File: 127232-41-1.mol

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5-ISOXAZOLEMETHANOL Property

Boiling point:: 212.8±15.0 °C(Predicted)
Density: 1.250±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 13.41±0.10(Predicted)
form: low melting solid
color: Colourless to light yellow

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22-41
Safety Statements: 26-39
Hazard Note: Irritant
HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: A604566
Product name: Oxazol-5-ylmethanol
Packaging: 100mg
Price: $90
Updated: 2021/12/16

ChemScene

Product number: CS-W003570
Product name: Oxazol-5-ylmethanol
Purity: >97.0%
Packaging: 1g
Price: $140
Updated: 2021/12/16

ChemScene

Product number: CS-W003570
Product name: Oxazol-5-ylmethanol
Purity: >97.0%
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 084229
Product name: 1,3-Oxazol-5-ylmethanol
Purity: 97%
Packaging: 1g
Price: $155
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H01-1-03
Product name: 1,3-Oxazol-5-ylmethanol
Purity: 98%
Packaging: 250mg
Price: $164
Updated: 2021/12/16

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5-ISOXAZOLEMETHANOL Chemical Properties,Usage,Production

Synthesis

118994-89-1

127232-41-1

General procedure for the synthesis of oxazole-5-methanol from ethyl oxazole-5-carboxylate: a solution of ethyl oxazole-5-carboxylate (29.13 g, 0.207 mol) in THF (206 mL) was slowly added dropwise to a suspension of LiAlH4 (7.85 g, 0.207 mmol) in THF (206 mL) at 0 °C. The reaction mixture was stirred continuously at 0 °C for 30 min (the progress of the reaction was monitored by TLC to confirm complete consumption of the feedstock). Subsequently, the reaction was quenched by sequential addition of water (8 mL), 10% NaOH solution (8 mL), and water (24 mL) (care was taken to control the reaction temperature to not exceed 0 °C). The reaction mixture was filtered, the precipitate was collected and washed several times with THF. The filtrates were combined and concentrated under reduced pressure to give crude oxazole-5-methanol (17.7 g, 86% yield), which could be used for subsequent reactions without further purification.

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 367 - 391
[2] Tetrahedron Letters, 2006, vol. 47, # 4, p. 549 - 552
[3] Tetrahedron, 2008, vol. 64, # 21, p. 4778 - 4791
[4] Collection of Czechoslovak Chemical Communications, 2009, vol. 74, # 6, p. 887 - 900
[5] Patent: WO2015/118019, 2015, A1. Location in patent: Page/Page column 35; 36

5-ISOXAZOLEMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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5-ISOXAZOLEMETHANOL Suppliers

China 99 Germany 2 India 2 United Kingdom 1 United States 19 Global 123

Energy Chemical

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NovoChemy Ltd.

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View Lastest Price from 5-ISOXAZOLEMETHANOL manufacturers

Career Henan Chemical Co

Product: 5-ISOXAZOLEMETHANOL 127232-41-1
Price: US $0.01/KG
Min. Order: 500g
Purity: 98%; 99%
Supply Ability: 500g；1kg； 10kg; 25kg
Release date: 2020-01-08

127232-41-1, 5-ISOXAZOLEMETHANOLRelated Search:

ETHYL OXAZOLE-5-CARBOXYLATE OXAZOLE-5-CARBOXYLIC ACID ETHYL 2-OXAZOLECARBOXYLATE 5-OXAZOLECARBOXALDEHYDE OXAZOL-4-YL-METHYLAMINE HYDROCHLORIDE SodiuM oxazole-2-carboxylate Methyl 5-oxazolecarboxylate Oxazole-2-carbaldehyde OXAZOLE-5-CARBONITRILE Oxazole-4-carbaldehyde 4-Oxazolecarboxylic acid, methyl ester (9CI) 5-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-oxazole OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Oxazolo[4,5-b]pyridine 2-OXAZOLEMETHANOL Oxazolo[4,5-c]pyridin-2-amine (9CI) 2-OXAZOLECARBONITRILE Ethyl 4-methyl-1,3-oxazole-5-carboxylate

OXAZOLE-5-METHANOL

5-ISOXAZOLEMETHANOL

AKOS PAO-1429

ISOXAZOL-5-YL-METHANOL

5-(Hydroxymethyl)-1,3-oxazole

5-(Hydroxymethyl)-1,3-oxazole 95%

5-oxazolylmethanol

5-hydroxymethyloxazole

1,3-Oxazol-5-methanol

1,3-Oxazol-5-ylmethanol

Oxazol-5-ylMethanol

5-OxazoleMethanol

127232-41-1

blocks

Oxazoles