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2-OXAZOLEMETHANOL

Product Name
2-OXAZOLEMETHANOL
CAS No.
130551-92-7
Chemical Name
2-OXAZOLEMETHANOL
Synonyms
2-OXAZOLEMETHANOL;oxazol-2-ylmethanol;2-HYDROXYMETHYL OXAZOLE;2-Oxazolemethanol (9CI, ACI)
CBNumber
CB2837741
Molecular Formula
C4H5NO2
Formula Weight
99.09
MOL File
130551-92-7.mol
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2-OXAZOLEMETHANOL Property

Boiling point:
175℃
Density 
1.250
Flash point:
59℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
13.28±0.10(Predicted)
form 
liquid
color 
Light Brown
InChI
InChI=1S/C4H5NO2/c6-3-4-5-1-2-7-4/h1-2,6H,3H2
InChIKey
IEHJKGRLVGZCMX-UHFFFAOYSA-N
SMILES
O1C=CN=C1CO
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
O846518
Product name
2-Oxazolemethanol
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-1-X4
Product name
2-(Hydroxymethyl)-1,3-oxazole
Packaging
250mg
Price
$165
Updated
2021/12/16
Matrix Scientific
Product number
084230
Product name
2-(Hydroxymethyl)-1,3-oxazole
Purity
97%
Packaging
1g
Price
$218
Updated
2021/12/16
AK Scientific
Product number
5578AA
Product name
Oxazol-2-ylmethanol
Packaging
1g
Price
$337
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-1-X4
Product name
2-(Hydroxymethyl)-1,3-oxazole
Packaging
1g
Price
$420
Updated
2021/12/16
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2-OXAZOLEMETHANOL Chemical Properties,Usage,Production

Uses

2-Oxazolemethanol is used in the synthetic preparation of pyridazine derivatives as EAAT2 activators for treating or preventing diseases.

Synthesis

65373-52-6

130551-92-7

General procedure for the synthesis of 2-hydroxymethyl oxazole from oxazole-2-carboxaldehyde: To a methanol (25 mL) solution of oxazole-2-carboxaldehyde (90 mg, 9.28 mmol) was slowly added sodium borohydride (420 mg, 11.14 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water (25 mL), and the organic phase was extracted with ethyl acetate, followed by washing with saturated brine solution (50 mL), drying with anhydrous sodium sulfate, filtration, and concentration to afford the crude product, 2-hydroxymethyl oxazole. The crude product was purified by column chromatography (silica gel 100-200 mesh, eluent 50% ethyl acetate/petroleum ether) to give purified 2-hydroxymethoxazole (160 mg, 14% yield) as a colorless liquid. Thin layer chromatography (TLC) Rf value was 0.4 (50% ethyl acetate/petroleum ether).1H-NMR (400 MHz, CDCl3): δ 7.64 (s, 1H), 7.09 (s, 1H), 4.75 (s, 2H). Mass spectrum (m/z, APCI positive ion mode): 100.3 ([M+H]+).

References

[1] Patent: WO2011/35009, 2011, A1. Location in patent: Page/Page column 46
[2] Journal of Organic Chemistry, 1991, vol. 56, # 1, p. 449 - 452
[3] Patent: WO2007/34144, 2007, A1. Location in patent: Page/Page column 93
[4] Patent: WO2005/102998, 2005, A1. Location in patent: Page/Page column 31-32

2-OXAZOLEMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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2-OXAZOLEMETHANOL Suppliers

China 74 India 1 Switzerland 1 United Kingdom 2 United States 13 Global 91
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
150-2103-5486 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9342
Advantage
55
Wuhan Kaymke Chemical Co., Ltd.,
Tel
027-027-87342388 18086026008
Fax
027-87342388
Email
sales@kaymke.com
Country
China
ProdList
3732
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Shanghai ChriChem Co., Ltd.
Tel
021-54880687
Fax
021-54880687
Country
China
ProdList
511
Advantage
55
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View Lastest Price from 2-OXAZOLEMETHANOL manufacturers

Career Henan Chemical Co
Product
2-OXAZOLEMETHANOL 130551-92-7
Price
US $5.50/KG
Min. Order
1KG
Purity
98%min
Supply Ability
1kg-100kg
Release date
2020-01-08

130551-92-7, 2-OXAZOLEMETHANOLRelated Search:

ETHYL 2-OXAZOLECARBOXYLATE Oxazole-2-carbaldehyde OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Oxazolo[4,5-b]pyridine 5-ISOXAZOLEMETHANOL Oxazolo[4,5-c]pyridin-2-amine (9CI) 2-OXAZOLECARBONITRILE Eclazolast Quazolast 2-OXAZOLECARBOXYLIC ACID 2-OXAZOLEMETHANOL oxazofurin BENZOOXAZOL-2-YL-PHENYL-METHANOL 5-PYRIDIN-3-YL-OXAZOLE-2-CARBOXYLIC ACID BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL 2-OXAZOLECARBOXYLATE BENZOOXAZOL-2-YL-METHANOL METHYL 5-METHOXY-1,3-OXAZOLE-2-CARBOXYLATE

  • 2-OXAZOLEMETHANOL
  • 2-HYDROXYMETHYL OXAZOLE
  • oxazol-2-ylmethanol
  • 2-Oxazolemethanol (9CI, ACI)
  • 130551-92-7