ChemicalBook > CAS DataBase List > 2-OXAZOLEMETHANOL

2-OXAZOLEMETHANOL

Product Name
2-OXAZOLEMETHANOL
CAS No.
130551-92-7
Chemical Name
2-OXAZOLEMETHANOL
Synonyms
2-OXAZOLEMETHANOL;oxazol-2-ylmethanol;2-HYDROXYMETHYL OXAZOLE;2-Oxazolemethanol (9CI, ACI)
CBNumber
CB2837741
Molecular Formula
C4H5NO2
Formula Weight
99.09
MOL File
130551-92-7.mol
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2-OXAZOLEMETHANOL Property

Boiling point:
175℃
Density 
1.250
Flash point:
59℃
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
13.28±0.10(Predicted)
form 
liquid
color 
Light Brown
InChI
InChI=1S/C4H5NO2/c6-3-4-5-1-2-7-4/h1-2,6H,3H2
InChIKey
IEHJKGRLVGZCMX-UHFFFAOYSA-N
SMILES
O1C=CN=C1CO
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
O846518
Product name
2-Oxazolemethanol
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-1-X4
Product name
2-(Hydroxymethyl)-1,3-oxazole
Packaging
250mg
Price
$165
Updated
2021/12/16
Matrix Scientific
Product number
084230
Product name
2-(Hydroxymethyl)-1,3-oxazole
Purity
97%
Packaging
1g
Price
$218
Updated
2021/12/16
AK Scientific
Product number
5578AA
Product name
Oxazol-2-ylmethanol
Packaging
1g
Price
$337
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-1-X4
Product name
2-(Hydroxymethyl)-1,3-oxazole
Packaging
1g
Price
$420
Updated
2021/12/16
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2-OXAZOLEMETHANOL Chemical Properties,Usage,Production

Uses

2-Oxazolemethanol is used in the synthetic preparation of pyridazine derivatives as EAAT2 activators for treating or preventing diseases.

Synthesis

65373-52-6

130551-92-7

General procedure for the synthesis of 2-hydroxymethyl oxazole from oxazole-2-carboxaldehyde: To a methanol (25 mL) solution of oxazole-2-carboxaldehyde (90 mg, 9.28 mmol) was slowly added sodium borohydride (420 mg, 11.14 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water (25 mL), and the organic phase was extracted with ethyl acetate, followed by washing with saturated brine solution (50 mL), drying with anhydrous sodium sulfate, filtration, and concentration to afford the crude product, 2-hydroxymethyl oxazole. The crude product was purified by column chromatography (silica gel 100-200 mesh, eluent 50% ethyl acetate/petroleum ether) to give purified 2-hydroxymethoxazole (160 mg, 14% yield) as a colorless liquid. Thin layer chromatography (TLC) Rf value was 0.4 (50% ethyl acetate/petroleum ether).1H-NMR (400 MHz, CDCl3): δ 7.64 (s, 1H), 7.09 (s, 1H), 4.75 (s, 2H). Mass spectrum (m/z, APCI positive ion mode): 100.3 ([M+H]+).

References

[1] Patent: WO2011/35009, 2011, A1. Location in patent: Page/Page column 46
[2] Journal of Organic Chemistry, 1991, vol. 56, # 1, p. 449 - 452
[3] Patent: WO2007/34144, 2007, A1. Location in patent: Page/Page column 93
[4] Patent: WO2005/102998, 2005, A1. Location in patent: Page/Page column 31-32

2-OXAZOLEMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-OXAZOLEMETHANOL manufacturers

Career Henan Chemical Co
Product
2-OXAZOLEMETHANOL 130551-92-7
Price
US $5.50/KG
Min. Order
1KG
Purity
98%min
Supply Ability
1kg-100kg
Release date
2020-01-08

130551-92-7, 2-OXAZOLEMETHANOLRelated Search:

ETHYL 2-OXAZOLECARBOXYLATE Oxazole-2-carbaldehyde OXAZOLO[4,5-B]PYRIDIN-2(3H)THIONE Oxazolo[4,5-b]pyridine 5-ISOXAZOLEMETHANOL Oxazolo[4,5-c]pyridin-2-amine (9CI) 2-OXAZOLECARBONITRILE Eclazolast Quazolast 2-OXAZOLECARBOXYLIC ACID 2-OXAZOLEMETHANOL oxazofurin BENZOOXAZOL-2-YL-PHENYL-METHANOL 5-PYRIDIN-3-YL-OXAZOLE-2-CARBOXYLIC ACID BENZOOXAZOLE-2-CARBOXYLIC ACID METHYL 2-OXAZOLECARBOXYLATE BENZOOXAZOL-2-YL-METHANOL METHYL 5-METHOXY-1,3-OXAZOLE-2-CARBOXYLATE

  • 2-OXAZOLEMETHANOL
  • 2-HYDROXYMETHYL OXAZOLE
  • oxazol-2-ylmethanol
  • 2-Oxazolemethanol (9CI, ACI)
  • 130551-92-7