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2-OXAZOLECARBONITRILE

Product Name
2-OXAZOLECARBONITRILE
CAS No.
68776-60-3
Chemical Name
2-OXAZOLECARBONITRILE
Synonyms
2-CYANO-OXAZOLE;2-OXAZOLECARBONITRILE;oxazole-2-carbonitrile;1,3-oxazole-2-carbonitrile
CBNumber
CB7841994
Molecular Formula
C4H2N2O
Formula Weight
94.07
MOL File
68776-60-3.mol
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2-OXAZOLECARBONITRILE Property

Boiling point:
165.7±23.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-3.49±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
C998778
Product name
2-Cyano-oxazole
Packaging
10mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC106345
Product name
2-Cyano-oxazole
Packaging
10mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC106345
Product name
2-Cyano-oxazole
Packaging
25mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC106345
Product name
2-Cyano-oxazole
Packaging
50mg
Price
$160
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC106345
Product name
2-Cyano-oxazole
Packaging
100mg
Price
$258
Updated
2021/12/16
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2-OXAZOLECARBONITRILE Chemical Properties,Usage,Production

Synthesis

884539-45-1

68776-60-3

Example 112: Synthesis of 1,3-oxazole-2-carbonitrile; 1,3-oxazole-2-carboxamide (0.98 g, 8.8 mmol, 1.0 eq.) was dissolved in pyridine (17 mL), followed by the addition of phosphorus triclosan (1.2 mL, 12.2 mmol, 1.4 eq.). The reaction mixture was stirred at room temperature for 5 h. The solution was observed to change from a beige slurry to a brown color. After completion of the reaction, the mixture was diluted with ice water and extracted with ether. The aqueous layer was adjusted to pH 3 with 6 M hydrochloric acid and extracted again with ether. The combined ether extracts were washed sequentially with water and saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 1,3-oxazole-2-carbonitrile as an amber colored oil (0.61 g, 74% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.608 (s, 1H), 7.67 (s, 1H).

References

[1] Patent: WO2006/43145, 2006, A1. Location in patent: Page/Page column 131
[2] Patent: WO2010/45009, 2010, A1. Location in patent: Page/Page column 40-41
[3] Patent: WO2010/45015, 2010, A1. Location in patent: Page/Page column 27
[4] Patent: WO2010/45016, 2010, A1. Location in patent: Page/Page column 20

2-OXAZOLECARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-OXAZOLECARBONITRILE Suppliers

China DongFan Chemical Co.,LTD
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86-0571-85151182
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66028182 18626450290
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JW & Y Pharmlab Co., Ltd.
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Amadis Chemical Company Limited
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SHANGHAI FDC-CHEMICAL CO.,LTD
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3A Chemicals
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68776-60-3, 2-OXAZOLECARBONITRILERelated Search:


  • 2-OXAZOLECARBONITRILE
  • oxazole-2-carbonitrile
  • 2-CYANO-OXAZOLE
  • 1,3-oxazole-2-carbonitrile
  • 68776-60-3