2-OXAZOLEMETHANOL
- Product Name
- 2-OXAZOLEMETHANOL
- CAS No.
- 130551-92-7
- Chemical Name
- 2-OXAZOLEMETHANOL
- Synonyms
- 2-OXAZOLEMETHANOL;oxazol-2-ylmethanol;2-HYDROXYMETHYL OXAZOLE;2-Oxazolemethanol (9CI, ACI)
- CBNumber
- CB2837741
- Molecular Formula
- C4H5NO2
- Formula Weight
- 99.09
- MOL File
- 130551-92-7.mol
2-OXAZOLEMETHANOL Property
- Boiling point:
- 175℃
- Density
- 1.250
- Flash point:
- 59℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 13.28±0.10(Predicted)
- form
- liquid
- color
- Light Brown
- InChI
- InChI=1S/C4H5NO2/c6-3-4-5-1-2-7-4/h1-2,6H,3H2
- InChIKey
- IEHJKGRLVGZCMX-UHFFFAOYSA-N
- SMILES
- O1C=CN=C1CO
Safety
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- O846518
- Product name
- 2-Oxazolemethanol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H01-1-X4
- Product name
- 2-(Hydroxymethyl)-1,3-oxazole
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 084230
- Product name
- 2-(Hydroxymethyl)-1,3-oxazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $218
- Updated
- 2021/12/16
- Product number
- 5578AA
- Product name
- Oxazol-2-ylmethanol
- Packaging
- 1g
- Price
- $337
- Updated
- 2021/12/16
- Product number
- 4H01-1-X4
- Product name
- 2-(Hydroxymethyl)-1,3-oxazole
- Packaging
- 1g
- Price
- $420
- Updated
- 2021/12/16
2-OXAZOLEMETHANOL Chemical Properties,Usage,Production
Uses
2-Oxazolemethanol is used in the synthetic preparation of pyridazine derivatives as EAAT2 activators for treating or preventing diseases.
Synthesis
65373-52-6
130551-92-7
General procedure for the synthesis of 2-hydroxymethyl oxazole from oxazole-2-carboxaldehyde: To a methanol (25 mL) solution of oxazole-2-carboxaldehyde (90 mg, 9.28 mmol) was slowly added sodium borohydride (420 mg, 11.14 mmol) at 0 °C. The reaction mixture was gradually warmed to room temperature and stirred continuously for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of water (25 mL), and the organic phase was extracted with ethyl acetate, followed by washing with saturated brine solution (50 mL), drying with anhydrous sodium sulfate, filtration, and concentration to afford the crude product, 2-hydroxymethyl oxazole. The crude product was purified by column chromatography (silica gel 100-200 mesh, eluent 50% ethyl acetate/petroleum ether) to give purified 2-hydroxymethoxazole (160 mg, 14% yield) as a colorless liquid. Thin layer chromatography (TLC) Rf value was 0.4 (50% ethyl acetate/petroleum ether).1H-NMR (400 MHz, CDCl3): δ 7.64 (s, 1H), 7.09 (s, 1H), 4.75 (s, 2H). Mass spectrum (m/z, APCI positive ion mode): 100.3 ([M+H]+).
References
[1] Patent: WO2011/35009, 2011, A1. Location in patent: Page/Page column 46
[2] Journal of Organic Chemistry, 1991, vol. 56, # 1, p. 449 - 452
[3] Patent: WO2007/34144, 2007, A1. Location in patent: Page/Page column 93
[4] Patent: WO2005/102998, 2005, A1. Location in patent: Page/Page column 31-32
2-OXAZOLEMETHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
2-OXAZOLEMETHANOL Suppliers
- Tel
- --
- Fax
- --
- contact@achemica.com
- Country
- Switzerland
- ProdList
- 6155
- Advantage
- 50
View Lastest Price from 2-OXAZOLEMETHANOL manufacturers
- Product
- 2-OXAZOLEMETHANOL 130551-92-7
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-08