ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE
- Product Name
- ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE
- CAS No.
- 107407-80-7
- Chemical Name
- ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE
- Synonyms
- Ethylpyrrol[1,2-c]pyrimidine-3-carboxylate;Ethyl pyrrolo[1,2-c]pyriMidin-3-carboxylate;ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE;ethyl pyrrolo[1,2-f]pyrimidine-3-carboxylate;Pyrrolo<1,2-c>pyrimidin-3-carbonsaeure-ethylester;3-pyrrolo[1,2-c]pyrimidinecarboxylic acid ethyl ester;Pyrrolo[1,2-c]pyrimidine-3-carboxylic acid, ethyl ester;3-[ethoxy(oxo)Methane]pyrazolo[1,2-a][1,2,4]triazin-1-yl;ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE ISO 9001：2015 REACH
- CBNumber
- CB2201483
- Molecular Formula
- C10H10N2O2
- Formula Weight
- 190.2
- MOL File
- 107407-80-7.mol
ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE Property
- Melting point:
- 69-70°C
- Density
- 1.22±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.16±0.30(Predicted)
- Appearance
- Light yellow to light brown Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- Y6980
- Product name
- Ethylpyrrolo[1,2-c]pyrimidine-3-carboxylate
- Packaging
- 100mg
- Price
- $192
- Updated
- 2021/12/16
- Product number
- 043285
- Product name
- Ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $267
- Updated
- 2021/12/16
- Product number
- Y6980
- Product name
- Ethylpyrrolo[1,2-c]pyrimidine-3-carboxylate
- Packaging
- 250mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- OR32327
- Product name
- Ethylpyrrolo[1,2-c]pyrimidine-3-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $298
- Updated
- 2021/12/16
- Product number
- 043285
- Product name
- Ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $410
- Updated
- 2021/12/16
ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
1003-29-8
2999-46-4
107407-80-7
General procedure for the synthesis of ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate from 2-pyrrole carboxaldehyde and ethyl isocyanoacetate: to a solution of 1H-pyrrole-2-carboxaldehyde (9.51 g, 100.0 mmol, 1.0 eq.) in dichloromethane (DCM, 150.0 mL) was added 1,8-diazadicyclohexadec-7-ene (DBU, 15.2 g, 100.0 mmol, 1.0 eq.). 100.0 mmol, 1.0 equiv) followed by ethyl isocyanoacetate (11.3 g, 100.0 mmol, 1.0 equiv). The reaction mixture was heated to reflux and maintained for 3 hours. Upon completion of the reaction, the reaction was quenched by the addition of 10% aqueous acetic acid (250 mL) and the organic phase was separated. The organic phase was washed sequentially with water (100 mL x 2), dried over anhydrous magnesium sulfate (MgSO?), filtered and concentrated. The residue was purified by column chromatography (petroleum ether/ethyl acetate=4/1, v/v) to afford the target product ethyl pyrrolo[1,2-c]pyrimidine-3-carboxylate as a yellow solid (18.5 g, 97.3% yield).
References
[1] Patent: WO2018/35061, 2018, A1. Location in patent: Paragraph 0448
[2] Organic and Biomolecular Chemistry, 2015, vol. 13, # 14, p. 4231 - 4239
[3] Patent: US2003/236264, 2003, A1. Location in patent: Page 49
[4] Tetrahedron Letters, 1996, vol. 37, # 24, p. 4263 - 4266
ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE manufacturers
- Product
- ETHYL PYRROLO[1,2-C]PYRIMIDINE-3-CARBOXYLATE 107407-80-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12