3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID
- Product Name
- 3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID
- CAS No.
- 143438-91-9
- Chemical Name
- 3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID
- Synonyms
- RARECHEM AK HW 0018;3-TrifluoroMethyl-DL-b-phenylalanine;3-[3-(TRIFLUOROMETHYL)PHENYL]-BETA-ALANINE;(R)-1-(4-chloro-2-fluorophenyl)propan-1-amine;Benzenepropanoic acid, β-amino-3-(trifluoromethyl)-;3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID;3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID;DL-3-Amino-3-(3-trifluoromethylphenyl)propanoic acid;DL-3-AMINO-3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID;(RS)-3-Amino-3-(3-trifluoromethylphenyl)-propionic acid
- CBNumber
- CB2203250
- Molecular Formula
- C10H10F3NO2
- Formula Weight
- 233.19
- MOL File
- 143438-91-9.mol
3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID Property
- Melting point:
- 210-212°C
- Boiling point:
- 295.2±40.0 °C(Predicted)
- Density
- 1.361±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 3.58±0.10(Predicted)
- Appearance
- White to light yellow Solid
- CAS DataBase Reference
- 143438-91-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2922498590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A631295
- Product name
- 3-Amino-3-(3-trifluoromethylphenyl)propanoicAcid
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- W3125
- Product name
- 3-Amino-3-[3-(trifluoromethyl)phenyl]-propanoicacid
- Packaging
- 5g
- Price
- $266
- Updated
- 2021/12/16
- Product number
- 045107
- Product name
- 3-Amino-3-[3-(trifluoromethyl)phenyl]-propanoic acid
- Purity
- >95%
- Packaging
- 500mg
- Price
- $362
- Updated
- 2021/12/16
- Product number
- 4857-3-75
- Product name
- 3-Amino-3-[3-(trifluoromethyl)phenyl]propanoic acid
- Packaging
- 1g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- 045107
- Product name
- 3-Amino-3-[3-(trifluoromethyl)phenyl]-propanoic acid
- Purity
- >95%
- Packaging
- 1g
- Price
- $454
- Updated
- 2021/12/16
3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID Chemical Properties,Usage,Production
Synthesis
141-82-2
454-89-7
143438-91-9
1. malonic acid (298.82 g, 2.872 mol), ammonium formate (362.14 g, 5.743 mol), and 3-(trifluoromethyl)benzaldehyde (500 g, 2.873 mol) were mixed in 1000 mL of ethanol. 2. The mixture was heated and refluxed for 12 h. 3. Upon completion of the reaction, ethanol was removed by evaporation. 4. The residue was milled with 2500 The residue was ground with 2500 mL of acetone. 5. The solid was collected by filtration and dried to give 3-amino-3-[3-(trifluoromethyl)phenyl]propanoic acid (255 g) as a white solid. 6. The product was confirmed by NMR hydrogen spectroscopy (400 MHz, AcOH-d4): δ 7.87-7.81 (m, 2H), 7.74 (d, 1H, J = 7.6 Hz), 7.66- 7.62 (m, 1H), 7.66- 7.62 (m, 1H). 7.62 (m, 1H), 4.98 (br.s, 1H), 3.36 (dd, 1H, J = 16.0, 8.0 Hz), 3.13 (dd, 1H, J = 17.6, 5.6 Hz). 7. Mass spectrometry analysis revealed: m/z 234 (M + 1).
References
[1] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 4, p. 2440 - 2446
[2] Patent: WO2017/144183, 2017, A1. Location in patent: Page/Page column 65
3-AMINO-3-[3-(TRIFLUOROMETHYL)PHENYL]PROPANOIC ACID Preparation Products And Raw materials
Raw materials
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