CHLOROMETHYL PHENYL SULFONE
- Product Name
- CHLOROMETHYL PHENYL SULFONE
- CAS No.
- 7205-98-3
- Chemical Name
- CHLOROMETHYL PHENYL SULFONE
- Synonyms
- Ai3-09778;Einecs 230-581-8;CHLOROMETHYL PHENYL;CHLOROMETHYL PHENYL SULFONE;PHENYL CHLOROMETHYL SULFONE;2-ChloroMethylphenylsulfone;chloromethyl phenyl sulphone;(Phenylsulfonyl)chloromethane;Phenylsulfonylmethyl chloride;[(CHLOROMETHYL)SULFONYL]BENZENE
- CBNumber
- CB2210252
- Molecular Formula
- C7H7ClO2S
- Formula Weight
- 190.65
- MOL File
- 7205-98-3.mol
CHLOROMETHYL PHENYL SULFONE Property
- Melting point:
- 51-53 °C (lit.)
- Boiling point:
- 130 °C / 1mmHg
- Density
- 1.336±0.06 g/cm3(Predicted)
- Flash point:
- >230 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Almost white
- BRN
- 2046644
- InChIKey
- NXAIQSVCXQZNRY-UHFFFAOYSA-N
- CAS DataBase Reference
- 7205-98-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 324604
- Product name
- Chloromethyl phenyl sulfone
- Purity
- ≥97%
- Packaging
- 5g
- Price
- $61.1
- Updated
- 2023/06/20
- Product number
- C1571
- Product name
- Chloromethyl Phenyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $135
- Updated
- 2025/07/31
- Product number
- C1571
- Product name
- Chloromethyl Phenyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $441
- Updated
- 2025/07/31
- Product number
- C587935
- Product name
- Chloromethyl Phenyl Sulfone
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC54887
- Product name
- 1-(Chloromethylsulfonyl)benzene
- Packaging
- 2g
- Price
- $84
- Updated
- 2021/12/16
CHLOROMETHYL PHENYL SULFONE Chemical Properties,Usage,Production
Uses
Chloromethyl Phenyl Sulfone is used to synthesis of α,β-epoxy sulfones and aziridines; reacts with electrophilic arenes, heterocyclic arenes, and alkenes; source of the α-phenylsulfonylmethyl radical.
Preparation
Preparative Methods of Chloromethyl Phenyl Sulfone: several methods are available. The most convenient is the reaction of Sodium Benzenesulfinate dihydrate with bromochloromethane in dimethyl sulfoxide.
Synthesis
100-68-5
3112-85-4
7205-98-3
The general procedure for the synthesis of phenylmethyl sulfone and chloromethyl phenyl sulfone from methyl phenyl sulfide was as follows: 0.25 g (2 mmol) of methyl phenyl sulfide was used as a substrate and added to a 50 mL three-necked flask along with 10 mL of acetonitrile and 2 mL of water. The internal temperature of the flask was maintained at 23 °C. Subsequently, 0.09 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals were added in portions with continuous stirring. During the reaction, the internal temperature of the flask was increased to 28°C and then gradually decreased. GC analysis was performed 3 h after the start of the reaction and showed that 22% of the methyl phenyl sulfide was converted to methyl phenyl sulfoxide and 65% to methyl phenyl sulfone. By-products included 6% chloromethyl phenyl sulfoxide and 7% chloromethyl phenyl sulfone, and a total of 0.8% advanced chlorides. Addition of 0.79 g (4.8 mmol) of sodium hypochlorite pentahydrate crystals was continued and stirring was continued for 1 hour. At this point, the methyl phenyl sulfide and methyl phenyl sulfoxide completely disappeared and the yield of methyl phenyl sulfone increased to 87%. Impurities included 11% chloromethyl phenyl sulfone, 0.5% dichloromethyl phenyl sulfone and 1.3% trichloromethyl phenyl sulfone.
Solubility in organics
Chloromethyl Phenyl Sulfone is soluble in THF, CHCl3, CH2Cl2, and most organic solvents.
References
[1] Patent: JP2017/52730, 2017, A. Location in patent: Paragraph 0046
CHLOROMETHYL PHENYL SULFONE Preparation Products And Raw materials
Raw materials
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View Lastest Price from CHLOROMETHYL PHENYL SULFONE manufacturers
- Product
- CHLOROMETHYL PHENYL SULFONE 7205-98-3
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02