Ramelteon-d5

Product Name: Ramelteon-d5
CAS No.: 1134159-63-9
Chemical Name: Ramelteon-d5
Synonyms: Ramelteon-d5;N-{2-[(8S)-1H,2H,6H,7H,8H-indeno[5,4-b]furan-8-yl]ethyl}(2H?)propanamide
CBNumber: CB22104243
Molecular Formula: C16H21NO2
Formula Weight: 259.35
MOL File: 1134159-63-9.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25420
Product name: Ramelteon-d5
Purity: ≥99% deuterated forms (d1-d5)
Packaging: 500μg
Price: $215
Updated: 2023/01/06

Cayman Chemical

Product number: 25420
Product name: Ramelteon-d5
Purity: ≥99% deuterated forms (d1-d5)
Packaging: 1mg
Price: $409
Updated: 2023/01/06

American Custom Chemicals Corporation

Product number: RDL0007100
Product name: RAMELTEON-D5
Purity: 95.00%
Packaging: 5MG
Price: $498.27
Updated: 2021/12/16

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Ramelteon-d5 Chemical Properties,Usage,Production

Uses

Ramelteon-d5 is deuterium labeled Ramelteon. Ramelteon is a potent, highly selective, and orally active agonist of MT1/MT2 with Ki values of 14 and 112 pM, respectively. Ramelteon has the potential for the research of insomnia. Ramelteon consistently reduces sleep onset after long-term treatment, with no next-morning residual effects or rebound insomnia or withdrawal symptoms upon discontinuation[1][2].

IC 50

MT2; MT1

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Kato K, et al. Neurochemical properties of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist. Neuropharmacology. 2005;48(2):301-310. DOI:10.1016/j.neuropharm.2004.09.007
[3] Mayer G, et al. Efficacy and safety of 6-month nightly ramelteon administration in adults with chronic primary insomnia. Sleep. 2009;32(3):351-360. DOI:10.1093/sleep/32.3.351
[4] Hirai K, et al. Ramelteon (TAK-375) accelerates reentrainment of circadian rhythm after a phase advance of the light-dark cycle in rats. J Biol Rhythms. 2005;20(1):27-37. DOI:10.1177/0748730404269890
[5] Miyamoto M, et al. The sleep-promoting action of ramelteon (TAK-375) in freely moving cats. Sleep. 2004;27(7):1319-1325. DOI:10.1093/sleep/27.7.1319

Ramelteon-d5 Preparation Products And Raw materials

Raw materials

Preparation Products

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Ramelteon-d5 Suppliers

Canada 1 China 18 India 3 United States 2 Global 24

TLC PharmaChem Inc.

Tel: --
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Email: research@tlcpharmachem.com
Country: Canada
ProdList: 921
Advantage: 60

1134159-63-9, Ramelteon-d5Related Search:

3-(6,7-Dibromo-2,3-dihydrobenzofuran-5-yl)propanoic Acid Ramelteon Impurity 14 (E)-2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-ylidene)ethylamine 4-Hydroxy Ramelteon Ramelteon Metabolite M-II PropanaMide, N-[2-(1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)ethyl]- (R)-Ramelteon (S)-(+)-Ibuprofen Ramelteon Impurity 10 Ramelteon Impurity 1 HCl Acetonitrile, (1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-ylidene)-, (2E)- (R)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetic acid (S)-2-(2,6,7,8-tetrahydro-1H-indeno[5,4-b]furan-8-yl)acetic acid Ramelteon Impurity 6 Despropionyl Ramelteon Hydrochloride Ramelteon Impurity 22 2-(1,6,7,8-Tetrahydro-2H-indeno[5,4-b]furan-8-yl)ethylaMine hydrochloride Ramelteon

Ramelteon-d5

N-{2-[(8S)-1H,2H,6H,7H,8H-indeno[5,4-b]furan-8-yl]ethyl}(2H?)propanamide

1134159-63-9

C16H16NO2D5