(S)-(+)-Ibuprofen
- Product Name
- (S)-(+)-Ibuprofen
- CAS No.
- 51146-56-6
- Chemical Name
- (S)-(+)-Ibuprofen
- Synonyms
- DEXIBUPROFEN;(S)-IBUPROFEN;(S)-2-(4-Isobutylphenyl)propanoic acid;Seractil;Ramelteon-7;d-Ibuprofen;exibuprofen;Deibuprofen;Dextroprofen;(+)-Ibuprofen
- CBNumber
- CB0699655
- Molecular Formula
- C13H18O2
- Formula Weight
- 206.28
- MOL File
- 51146-56-6.mol
(S)-(+)-Ibuprofen Property
- Melting point:
- 49-53 °C(lit.)
- alpha
- 57 º (c=2, EtOH)
- Boiling point:
- 285.14°C (rough estimate)
- Density
- 1.0364 (rough estimate)
- refractive index
- 59 ° (C=2, EtOH)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.5 mg/mL
- form
- solid
- pka
- 4.41±0.10(Predicted)
- color
- white
- optical activity
- [α]20/D +59°, c = 2 in ethanol
- Water Solubility
- insoluble
- BRN
- 3590022
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- HEFNNWSXXWATRW-JTQLQIEISA-N
- CAS DataBase Reference
- 51146-56-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 375160
- Product name
- (S)-(+)-Ibuprofen
- Purity
- ReagentPlus , 99%
- Packaging
- 1g
- Price
- $58.3
- Updated
- 2024/03/01
- Product number
- 375160
- Product name
- (S)-(+)-Ibuprofen
- Purity
- ReagentPlus , 99%
- Packaging
- 5g
- Price
- $117
- Updated
- 2024/03/01
- Product number
- I0549
- Product name
- (S)-(+)-2-(4-Isobutylphenyl)propionic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $27
- Updated
- 2024/03/01
- Product number
- I0549
- Product name
- (S)-(+)-2-(4-Isobutylphenyl)propionic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 16793
- Product name
- (S)-Ibuprofen
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $43
- Updated
- 2024/03/01
(S)-(+)-Ibuprofen Chemical Properties,Usage,Production
Description
Dexibuprofen, the S-(+)-isomer of the widely used NSAID agent ibuprofen, was launched in Austria for the treatment of rheumatoid arthritis. While the racemic compound is commonly used clinically, the antiinflammatory activity is mediated via the S-isomer by inhibition of prostaglandin synthesis. It has also been demonstrated that the R-isomer is converted to the Santipode in vivo via a CoA thioester intermediate. Since CoA plays a pivotal role in intermediary metabolism and maintenance of the [acyl-CoA], generation of R-ibuprofen-CoA competitively inhibits many CoA-dependent reactions, which consequently produces perturbations of hepatocyte Intermediary metabolism and mitocondrial function. Pure S-ibuprofen usage, therefore, is preferred allowing a reduction in dosage level and an improved side effect profile.
Description
Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.
Chemical Properties
Colourless, Crystalline Solid
Originator
Gebro Broschek (Austria)
Uses
A nonsteroidal anti-inflammatory drug (NSAID); activity resides primarily in the (S)-isomer
Uses
sedative
Uses
Ibuprofen is a non-steroidal anti-inflammatory drug with diverse biochemical actions, most notably inhibiting COX-1 and COX-2 (IC50s = 2.6 and 1.53, μM, respectively). It is commonly synthesized as a racemic mixture of (S)- and (R)-isomers. (S)-Ibuprofen is an enantiomer that more potently inhibits COX activity, thromboxane formation, and platelet aggregation than the (R)-form. (S)-Ibuprofen also inhibits activation of NF-κB more effectively than (R)-ibuprofen (IC50s = 62 and 122 μM, respectively). However, the enantiomers are equipotent in blocking superoxide formation, β-glucuronidase release, and LTB4 generation by stimulated neutrophils (IC50 values range from 0.14 to 0.58 μM). A majority of (R)-ibuprofen can be inverted to (S)-ibuprofen in humans after oral administration.
Definition
ChEBI: Dexibuprofen is an ibuprofen. It has a role as a non-narcotic analgesic and a non-steroidal anti-inflammatory drug. It is an enantiomer of a levibuprofen.
brand name
Seractil
General Description
(S)-(+)-Ibuprofen is the enantiomer associated with the anti-inflammatory action of ibuprofen, which is widely used as a nonsteroidal anti-inflammatory drug in racemic form.
Biological Activity
Non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase 1 and cyclooxygenase 2 (IC 50 values are 12 and 80 μ M respectively). Active isomer of ibuprofen.
Clinical Use
NSAID and analgesic
Drug interactions
Potentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists:
antagonism of hypotensive effect, increased risk of
nephrotoxicity and hyperkalaemia.
Analgesics: avoid concomitant use of 2 or more
NSAIDs, including aspirin (increased side effects);
avoid with ketorolac (increased risk of side effects
and haemorrhage).
Antibacterials: possibly increased risk of convulsions
with quinolones.
Anticoagulants: effects of coumarins and
phenindione enhanced; possibly increased risk of
bleeding with heparins, dabigatran and edoxaban -
avoid long term use with edoxaban.
Antidepressants: increased risk of bleeding with
SSRIs and venlaflaxine.
Antidiabetic agents: effects of sulphonylureas
enhanced.
Antiepileptics: possibly increased phenytoin
concentration.
Antivirals: increased risk of haematological toxicity
with zidovudine; concentration possibly increased by
ritonavir
Ciclosporin: may potentiate nephrotoxicity
Cytotoxics: reduced excretion of methotrexate;
increased risk of bleeding with erlotinib
Diuretics: increased risk of nephrotoxicity;
antagonism of diuretic effect; hyperkalaemia with
potassium-sparing diuretics.
Lithium: excretion decreased.
Pentoxifylline: increased risk of bleeding.
Tacrolimus: increased risk of nephrotoxicity
Metabolism
Dexibuprofen is the S(+)-enantiomer of ibuprofen. After metabolic transformation in the liver (hydroxylation and carboxylation), the pharmacologically inactive metabolites are completely excreted, mainly by the kidneys (90%), but also in the bile.
Purification Methods
Crystallise the (+) and (-) acids from EtOH or aqueous EtOH. The racemate which crystallises from pet ether with m 75-77o is sparingly soluble in H2O and has IR (film) 1705 (C=O), 2300—3700 (OH broad)cm-1. It is used as a non-steroidal anti-inflammatory. [Shiori et al. J Org Chem 43 2936 1978, Kaiser et al. J Pharm Sci 65 269 1976, J Pharm Sci 81 221 1992, Freer Acta Cryst (C) 49 1378 1993 for the (S+)-enantiomer.]
(S)-(+)-Ibuprofen Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (S)-(+)-Ibuprofen manufacturers
- Product
- (S)-(+)-Ibuprofen 51146-56-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 98.5%-101%
- Supply Ability
- 1000kgs
- Release date
- 2021-08-03
- Product
- (S)-(+)-Ibuprofen 51146-56-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-10-31
- Product
- (S) - (+) -Ibuprofen 51146-56-6
- Price
- US $5.70/KG
- Min. Order
- 10KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-21