4-Chloropyrazole
- Product Name
- 4-Chloropyrazole
- CAS No.
- 15878-00-9
- Chemical Name
- 4-Chloropyrazole
- Synonyms
- AKOS B001464;4-clopyrazole;4-chloro-pyrazol;4-CHLOROPYRAZOLE;VITAS-BB TBB000653;ART-CHEM-BB B001464;4-chloro-1h-pyrazol;PYRAZOLE, 4-CHLORO-;4-CHLORO-1H-PYRAZOLE;4-Chloropyrazole >
- CBNumber
- CB2212438
- Molecular Formula
- C3H3ClN2
- Formula Weight
- 102.52
- MOL File
- 15878-00-9.mol
4-Chloropyrazole Property
- Melting point:
- 75-76 ºC
- Boiling point:
- 220 ºC
- Density
- 1.405
- Flash point:
- 99 ºC
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 12.71±0.50(Predicted)
- color
- White to Almost white
- λmax
- 224nm(lit.)
- InChI
- InChI=1S/C3H3ClN2/c4-3-1-5-6-2-3/h1-2H,(H,5,6)
- InChIKey
- BADSZRMNXWLUKO-UHFFFAOYSA-N
- SMILES
- N1C=C(Cl)C=N1
- CAS DataBase Reference
- 15878-00-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39
- RTECS
- UQ6445000
- HazardClass
- IRRITANT
- HS Code
- 2933199090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CDS019988
- Product name
- 4-Chloro-1H-pyrazole
- Purity
- AldrichCPR
- Packaging
- 100mg
- Price
- $70.9
- Updated
- 2024/03/01
- Product number
- C2888
- Product name
- 4-Chloropyrazole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- C2888
- Product name
- 4-Chloropyrazole
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $111
- Updated
- 2025/07/31
- Product number
- B418633
- Product name
- 4-Chloro-1H-pyrazole
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FC32604
- Product name
- 4-Chloro pyrazole
- Packaging
- 25g
- Price
- $60
- Updated
- 2021/12/16
4-Chloropyrazole Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystalline powder
Synthesis
288-13-1
15878-00-9
General method: synthesis of 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole. To a 16 mL reaction vial containing 1-benzyl-3,5-dimethyl-1H-pyrazole (196 mg, 1.05 mmol) and a magnetic stirrer, 0.7 mL of water and 0.3 mL of ethyl acetate were added sequentially. Subsequently, sodium chloride (123 mg, 2 mmol) was added and the reaction flask was placed in a room temperature water bath to control the exothermic nature of the reaction. Next, Oxone (322 mg, 0.52 mmol KHSO5) was added and the reaction vial was sealed. The reaction was carried out under continuous vigorous stirring until thin layer chromatography (TLC) analysis (1 h) showed complete consumption of the feedstock. The remaining oxidant was reduced by addition of solid sodium bisulfite until starch iodide paper tested negative. The reaction mixture was diluted with water (5 mL) and extracted with a 1:1 hexane/ether solvent mixture (3 x 5 mL). The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (14×1 cm, eluent 9:1 hexane/ethyl acetate) to afford pure 1-benzyl-4-chloro-3,5-dimethyl-1H-pyrazole as a light yellow oil (215 mg, 93% yield).
References
[1] Canadian Journal of Chemistry, 1991, vol. 69, # 3, p. 432 - 439
[2] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 6, p. 1621 - 1627
[3] Tetrahedron Letters, 2017, vol. 58, # 43, p. 4111 - 4114
[4] Advanced Synthesis and Catalysis, 2013, vol. 355, # 2-3, p. 499 - 507
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 52, p. 16132 - 16135
4-Chloropyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloropyrazole manufacturers
- Product
- 4-Chloropyrazole 15878-00-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30
- Product
- 4-Chloropyrazole 15878-00-9
- Price
- US $10.70/kg
- Min. Order
- 10kg
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-23
- Product
- 4-Chloropyrazole 15878-00-9
- Price
- US $6.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-24