ChemicalBook > CAS DataBase List > 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE

5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE

Product Name
5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
CAS No.
57489-77-7
Chemical Name
5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
Synonyms
oropyrazoL;o[1,5-a]pyrimidine;7-dichloropyrazolo[1;5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE;Pyrazolo[1,5-a]pyrimidine, 5,7-dichloro-;5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE CAS 57489-77-7
CBNumber
CB9387447
Molecular Formula
C6H3Cl2N3
Formula Weight
188.01
MOL File
57489-77-7.mol
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5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Property

Melting point:
68-71 °C(Solv: ethanol (64-17-5))
Density 
1.69±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
-1.68±0.30(Predicted)
InChI
InChI=1S/C6H3Cl2N3/c7-4-3-5(8)11-6(10-4)1-2-9-11/h1-3H
InChIKey
JMTFWCYVZOFHLR-UHFFFAOYSA-N
SMILES
C12=CC=NN1C(Cl)=CC(Cl)=N2
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D438268
Product name
5,7-Dichloropyrazolo[1,5-A]pyrimidine
Packaging
10mg
Price
$45
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
CAPOD13936
Product name
5,7-Dichloropyrazolo[1,5-a]pyrimidine
Packaging
1g
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD143003
Product name
5,7-Dichloropyrazolo[1,5-a]pyrimidine
Packaging
250mg
Price
$57.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD143003
Product name
5,7-Dichloropyrazolo[1,5-a]pyrimidine
Packaging
500mg
Price
$100
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-HL
Product name
5,7-Dichloropyrazolo[1,5-a]pyrimidine
Packaging
1g
Price
$109
Updated
2021/12/16
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5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production

Uses

5,7-Dichloropyrazolo[1,5-a]pyrimidine is a pharmaceutical intermediate compound that can be used in a palladium-catalysed pharmaceutical synthesis cross-coupling reaction. 2,4-Dichloroquinoline reacts with benzylzinc and phenylzinc reagents in the presence of catalytic quantities of palladium complexes to yield only α-substituted products.2,4-Dichloroquinolines have been found to react with benzylzinc and phenylzinc reagents in catalytic amounts of palladium compounds to produce only α-substituted products. LiCl was found to be an effective additive for γ-selective coupling reactions. These α- or γ-selective coupling conditions are applicable to the reaction of 5,7-Dichloropyrazolo[1,5-a]pyrimidine and biphenylmethyl zinc reagents in the synthesis of angiotensin II receptor antagonists. This regioselectivity should be generally applicable to other α,γ-dichloropyrazine systems[1].

References

[1] TAKESHI SHIOTA; Teruo Y. Regioselective Reactions of Organozinc Reagents with 2,4-Dichloroquinoline and 5,7-Dichloropyrazolo[1,5-a]pyrimidine[J]. ACS Applied Electronic Materials, 1999. DOI:10.1021/jo981423a.

5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Suppliers

China 194 China Hong Kong 1 Germany 2 India 5 United Kingdom 3 United States 21 Global 226
Suzhou Liyuan Biomedical Technology Co., Ltd.
Tel
0557-18949975665 18949975665
Email
1184800090@qq.com
Country
China
ProdList
450
Advantage
58
Shandong Baiqi Biomedical Co. Ltd
Tel
13173160180
Email
sales@baiqpharm.com
Country
China
ProdList
646
Advantage
58
Zhengzhou Ruike Biochemical Technology Co., Ltd.
Tel
18521304688
Email
421551521@qq.com
Country
China
ProdList
219
Advantage
58
Shandong Zhonghan Pharmaceutical Co.,Ltd.
Tel
15066662237 15066662237
Email
3281004549@qq.com
Country
China
ProdList
311
Advantage
55
Zhengzhou Ailfield Chemical Co., Ltd.
Tel
0311-84468392; 15993358503
Email
1013053532@qq.com
Country
China
ProdList
254
Advantage
58
Shanghai PharmOrgsyn Technology Co., LTD.
Tel
021-+86-021-38228826 13916602830;
Fax
sales@pharmorgsyn.com
Email
sales@pharmorgsyn.cn
Country
China
ProdList
244
Advantage
58
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
667
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55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
Suzhou Highfine Biotech Co., Ltd
Tel
0512-68311833 13962195826
Fax
0512-68417696
Email
wuhao@highfine.com
Country
China
ProdList
499
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75
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View Lastest Price from 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
5,7-dichloropyrazolo[1,5-a]pyrimidine 57489-77-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-15
Career Henan Chemical Co
Product
5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE 57489-77-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-11

57489-77-7, 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINERelated Search:

5,7-dichloroiMidazo[1,2-c]pyriMidine Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5,7-dichloro-, ethyl ester 3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-METHYLPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-3-METHYLPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-3-ETHYLPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(3-ISOPROPYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(4-METHOXYPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 2-(4-BROMOPHENYL)-5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(4-CHLOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(3-CHLOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(3-FLUOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(4-ISOPROPYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(3-METHYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(3-METHOXYPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE 5,7-DICHLORO-2-(4-METHYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE

  • 7-dichloropyrazolo[1
  • 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
  • Pyrazolo[1,5-a]pyrimidine, 5,7-dichloro-
  • o[1,5-a]pyrimidine
  • oropyrazoL
  • 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE CAS 57489-77-7
  • 57489-77-7
  • Heterocycle-Pyrimidine series
  • CHIRAL CHEMICALS