5,7-dichloroiMidazo[1,2-c]pyriMidine
- Product Name
- 5,7-dichloroiMidazo[1,2-c]pyriMidine
- CAS No.
- 85989-61-3
- Chemical Name
- 5,7-dichloroiMidazo[1,2-c]pyriMidine
- Synonyms
- 5,7-dichloroiMidazo[1,2-c]pyriMidine;Imidazo[1,2-c]pyrimidine, 5,7-dichloro-
- CBNumber
- CB52598098
- Molecular Formula
- C6H3Cl2N3
- Formula Weight
- 188.01
- MOL File
- 85989-61-3.mol
5,7-dichloroiMidazo[1,2-c]pyriMidine Property
- Density
- 1.69±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.91±0.30(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H3Cl2N3/c7-4-3-5-9-1-2-11(5)6(8)10-4/h1-3H
- InChIKey
- QMTXTHVMSRFISO-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC2=NC=CN12
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- D439743
- Product name
- 5,7-Dichloroimidazo[1,2-c]pyrimidine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR946694
- Product name
- 5,7-Dichloroimidazo[1,2-c]pyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- CS-W022279
- Product name
- 5,7-Dichloroimidazo[1,2-c]pyrimidine
- Packaging
- 250mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 3H32-5-MU
- Product name
- 5,7-Dichloroimidazo[1,2-c]pyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $232
- Updated
- 2021/12/16
- Product number
- OR946694
- Product name
- 5,7-Dichloroimidazo[1,2-c]pyrimidine
- Purity
- 95%
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
5,7-dichloroiMidazo[1,2-c]pyriMidine Chemical Properties,Usage,Production
Synthesis
56817-09-5
85989-61-3
General procedure for the synthesis of 5,7-dichloroimidazo[1,2-c]pyrimidines from 7-chloroimidazo[1,2-c]pyrimidin-5(6H)-ones: 38.3 g (225.86 mmol) of 7-chloroimidazo[1,2-c]pyrimidin-5(6H)-one was suspended in 450.2 g (2936 mmol) of phosphorochloridic acid chloride under argon protection. The reaction mixture was heated to 120°C for 4 hours. Upon completion of the reaction, the excess phosphoryl chloride was evaporated under reduced pressure and the residue was azeotropically distilled with toluene to further remove the residual phosphoryl chloride. The residue was suspended in water and the pH was adjusted to 7 with saturated aqueous sodium bicarbonate and the precipitated solid was collected by filtration. The solid was washed with water and dried for 18 hours using phosphorus pentoxide as the drying agent. Finally 33.5 g of the target product 5,7-dichloroimidazo[1,2-c]pyrimidine was obtained in 67% yield. The product was analyzed by LCMS (Method 6): retention time Rt = 1.01 min, m/z = 189 (M + H)+. 1H-NMR (400 MHz, DMSO-d6) data were as follows: δ= 8.11 (s, 1H), 7.94 (s, 1H), 7.81 (s, 1H).
References
[1] Patent: US2010/113441, 2010, A1. Location in patent: Page/Page column 27
[2] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 1, p. 42 - 46
[3] Patent: US2006/84650, 2006, A1. Location in patent: Page/Page column 87
5,7-dichloroiMidazo[1,2-c]pyriMidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,7-dichloroiMidazo[1,2-c]pyriMidine manufacturers
- Product
- 5,7-dichloroiMidazo[1,2-c]pyriMidine 85989-61-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-07
- Product
- 5,7-dichloroiMidazo[1,2-c]pyriMidine 85989-61-3
- Price
- US $0.00-0.00/G
- Min. Order
- 1G
- Purity
- 98%minHPLC
- Supply Ability
- 50kg/month
- Release date
- 2022-09-11