3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine

Product Name: 3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine
CAS No.: 114040-06-1
Chemical Name: 3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine
Synonyms: 3-Bromo-5,7-dichloropyrazolo[1,5-a]pyrimidine;Pyrazolo[1,5-a]pyrimidine, 3-bromo-5,7-dichloro-;3- bromide -5, 7- two chloro pyrazole, [1, 5-A] pyrimidine;3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine ISO 9001：2015 REACH
CBNumber: CB31504559
Molecular Formula: C6H2BrCl2N3
Formula Weight: 266.91
MOL File: 114040-06-1.mol

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3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine Property

Melting point:: 73-75 °C
Density: 2.16
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.17±0.40(Predicted)
Appearance: Yellow to brown Solid
InChI: InChI=1S/C6H2BrCl2N3/c7-3-2-10-12-5(9)1-4(8)11-6(3)12/h1-2H
InChIKey: CJIKMWXLGRVJMI-UHFFFAOYSA-N
SMILES: C12=C(Br)C=NN1C(Cl)=CC(Cl)=N2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B684655
Product name: 3-Bromo-5,7-dichloro-pyrazolo[1,5-a]pyrimidine
Packaging: 250mg
Price: $165
Updated: 2021/12/16

Matrix Scientific

Product number: 114081
Product name: 3-Bromo-5,7-dichloropyrazolo[1,5-a]pyrimidine
Purity: 97%
Packaging: 1g
Price: $99
Updated: 2021/12/16

AK Scientific

Product number: 2348AA
Product name: 3-Bromo-5,7-dichloropyrazolo[1,5-a]pyrimidine
Packaging: 1g
Price: $168
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0027694
Product name: 3-BROMO-5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
Purity: 95.00%
Packaging: 5MG
Price: $496.86
Updated: 2021/12/16

AK Scientific

Product number: 2348AA
Product name: 3-Bromo-5,7-dichloropyrazolo[1,5-a]pyrimidine
Packaging: 25g
Price: $1511
Updated: 2021/12/16

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3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine Chemical Properties,Usage,Production

Uses

3-Bromo-5,7-dichloro-pyrazolo[1,5-a]pyrimidine is an intermediate used in the synthesis of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 as an antiinflammatory target.

Synthesis

57489-77-7

114040-06-1

General procedure for the synthesis of 3-bromo-5,7-dichloropyrazolo[1,5-a]pyrimidines from 5,7-dichloropyrazolo[1,5-a]pyrimidines: To a solution of 5,7-dichloropyrazolo[1,5-a]pyrimidines (1 g, 5.32 mmol) in acetonitrile (20 mL) was added N-bromosuccinimide (1.04 g, 5.85 mmol) and ammonium ceric nitrate (0.029 g, 0.053 mmol). The reaction mixture was heated to reflux for 1 hour. After completion of the reaction, the reaction mixture was washed sequentially with 10% aqueous sodium bisulfite (30 mL) and brine (20 mL). The organic phase was dried with magnesium sulfate and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with 20% ether/hexane as eluent to afford 3-bromo-5,7-dichloropyrazolo[1,5-a]pyrimidine as a yellow solid (1.33 g, 92% yield). δH (400 MHz; d4-CDCl3) 8.22 (1H, s), 7.04 (1H, s).

References

[1] Patent: WO2004/87707, 2004, A1. Location in patent: Page 33; 34
[2] Patent: WO2014/75168, 2014, A1. Location in patent: Page/Page column 53
[3] Patent: WO2015/70349, 2015, A1. Location in patent: Page/Page column 22; 23
[4] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 7, p. 671 - 675
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 15, p. 6700 - 6715

3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine Preparation Products And Raw materials

Raw materials

Preparation Products

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3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine Suppliers

Canada 1 China 100 India 1 United States 13 Global 115

Chiba Pharmaceutical Science and technology Co, Ltd.

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J & K SCIENTIFIC LTD.

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SynAsst Chemical.

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View Lastest Price from 3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine manufacturers

Dideu Industries Group Limited

Product: 3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine 114040-06-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-01

Career Henan Chemical Co

Product: 3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine 114040-06-1
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-02

114040-06-1, 3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidineRelated Search:

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Pyrazolo[1,5-a]pyrimidine, 3-bromo-5,7-dichloro-

3-Bromo-5,7-dichloropyrazolo[1,5-a]pyrimidine

3- bromide -5, 7- two chloro pyrazole, [1, 5-A] pyrimidine

3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine ISO 9001：2015 REACH

114040-06-1

C6H2BrCl2N3

API intermediates