ChemicalBook > CAS DataBase List > 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
- Product Name
- 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
- CAS No.
- 57489-77-7
- Chemical Name
- 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
- Synonyms
- oropyrazoL;o[1,5-a]pyrimidine;7-dichloropyrazolo[1;5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE;Pyrazolo[1,5-a]pyrimidine, 5,7-dichloro-;5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE CAS 57489-77-7
- CBNumber
- CB9387447
- Molecular Formula
- C6H3Cl2N3
- Formula Weight
- 188.01
- MOL File
- 57489-77-7.mol
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5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Property
- Melting point:
- 68-71 °C(Solv: ethanol (64-17-5))
- Density
- 1.69±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -1.68±0.30(Predicted)
- InChI
- InChI=1S/C6H3Cl2N3/c7-4-3-5(8)11-6(10-4)1-2-9-11/h1-3H
- InChIKey
- JMTFWCYVZOFHLR-UHFFFAOYSA-N
- SMILES
- C12=CC=NN1C(Cl)=CC(Cl)=N2
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Safety
- HS Code
- 2933599590
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- D438268
- Product name
- 5,7-Dichloropyrazolo[1,5-A]pyrimidine
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
Frontier Specialty Chemicals
- Product number
- CAPOD13936
- Product name
- 5,7-Dichloropyrazolo[1,5-a]pyrimidine
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD143003
- Product name
- 5,7-Dichloropyrazolo[1,5-a]pyrimidine
- Packaging
- 250mg
- Price
- $57.5
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD143003
- Product name
- 5,7-Dichloropyrazolo[1,5-a]pyrimidine
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-5-HL
- Product name
- 5,7-Dichloropyrazolo[1,5-a]pyrimidine
- Packaging
- 1g
- Price
- $109
- Updated
- 2021/12/16
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5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production
Uses
5,7-Dichloropyrazolo[1,5-a]pyrimidine is a pharmaceutical intermediate compound that can be used in a palladium-catalysed pharmaceutical synthesis cross-coupling reaction. 2,4-Dichloroquinoline reacts with benzylzinc and phenylzinc reagents in the presence of catalytic quantities of palladium complexes to yield only α-substituted products.2,4-Dichloroquinolines have been found to react with benzylzinc and phenylzinc reagents in catalytic amounts of palladium compounds to produce only α-substituted products. LiCl was found to be an effective additive for γ-selective coupling reactions. These α- or γ-selective coupling conditions are applicable to the reaction of 5,7-Dichloropyrazolo[1,5-a]pyrimidine and biphenylmethyl zinc reagents in the synthesis of angiotensin II receptor antagonists. This regioselectivity should be generally applicable to other α,γ-dichloropyrazine systems[1].
References
[1] TAKESHI SHIOTA; Teruo Y. Regioselective Reactions of Organozinc Reagents with 2,4-Dichloroquinoline and 5,7-Dichloropyrazolo[1,5-a]pyrimidine[J]. ACS Applied Electronic Materials, 1999. DOI:10.1021/jo981423a.
5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE manufacturers
Shaanxi Dideu Medichem Co. Ltd
- Product
- 5,7-dichloropyrazolo[1,5-a]pyrimidine 57489-77-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
Career Henan Chemical Co
- Product
- 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE 57489-77-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11
57489-77-7, 5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINERelated Search:
5,7-dichloroiMidazo[1,2-c]pyriMidine
Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, 5,7-dichloro-, ethyl ester
3-broMo-5,7-dichloropyrazolo(1,5-a)pyriMidine
5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-METHYLPYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-3-METHYLPYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-3-ETHYLPYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-(3-ISOPROPYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-(4-METHOXYPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE
2-(4-BROMOPHENYL)-5,7-DICHLOROPYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-(4-CHLOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-(3-CHLOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-(3-FLUOROPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-(4-ISOPROPYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-(3-METHYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-(3-METHOXYPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-PHENYLPYRAZOLO[1,5-A]PYRIMIDINE
5,7-DICHLORO-2-(4-METHYLPHENYL)PYRAZOLO[1,5-A]PYRIMIDINE