(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

Product Name: (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
CAS No.: 149809-43-8
Chemical Name: (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester
Synonyms: (5R-cis)-Toluene-4-sulfonic acid;((3R,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate;2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol;Posaconazole A;Posaconazole int1;((3S,5R)-5-((1H-1;US-DMF No.: 033193;Posaconazole inter-1;Posaconazole Main Ring;Posaconazole Impurity 53
CBNumber: CB22128616
Molecular Formula: C21H21F2N3O4S
Formula Weight: 449.47
MOL File: 149809-43-8.mol

More

Less

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Property

Melting point:: 100-102°C
Boiling point:: 608.1±65.0 °C(Predicted)
Density: 1.40
storage temp.: -20°C Freezer, Under Inert Atmosphere
solubility: slightly sol. in Chloroform
form: powder to crystal
pka: 2.75±0.10(Predicted)
color: White to Orange to Green
InChIKey: DFWVLCJRFGIRAK-HRAATJIYSA-N
CAS DataBase Reference: 149809-43-8(CAS DataBase Reference)

More

Less

Safety

HS Code: 2934.99.4400

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H311Toxic in contact with skin

H331Toxic if inhaled

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P310Immediately call a POISON CENTER or doctor/physician.

P330Rinse mouth.

P361Remove/Take off immediately all contaminated clothing.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: D4537
Product name: (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $457
Updated: 2021/12/16

TCI Chemical

Product number: D4537
Product name: (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate
Purity: >98.0%(HPLC)
Packaging: 200mg
Price: $123
Updated: 2024/03/01

TRC

Product number: T535900
Product name: (5R-cis)-Toluene-4-sulfonicAcid5-(2,4-Difluorophenyl)-5-[1,2,4]triazol-1-ylmethyltetrahydrofuran-3-ylmethylEster
Packaging: 100mg
Price: $790
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0029265
Product name: (5R-CIS)-TOLUENE-4-SULFONIC ACID 5-(2,4-DIFLUOROPHENYL)-5-(1H-1,2,4-TRIAZOL-1-YL)METHYLTETRAHYDROFURAN-3-YLMETHYL ESTER
Purity: 95.00%
Packaging: 100MG
Price: $1709.98
Updated: 2021/12/16

Ark Pharm

Product number: P000097815
Product name: ((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate
Purity: 97%
Packaging: 5g
Price: $553
Updated: 2021/12/16

More

Less

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Chemical Properties,Usage,Production

Description

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester is a pharmaceutical intermediate ingredient for Posaconazole is one of the newest triazole antifungal agents approved by the FDA for the prevention of invasive Aspergillus and Candida infections in immunocompromised patients. Such patients include haematopoietic stem cell transplant patients with graft-versus-host disease and patients with haematological malignancies undergoing chemotherapy.

Chemical Properties

White Crystalline Solid

Uses

Posaconazole intermediate. Antifungal agent.

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester Suppliers

Americas 1 Canada 2 China 329 China Hong Kong 1 Europe 1 Germany 1 India 27 Japan 1 Switzerland 1 United Kingdom 2 United States 13 Global 379

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

KKyemistry (India) Pvt. Ltd.

Tel: --
Fax: --
Email: info@kyemistryindia.com
Country: India
ProdList: 197
Advantage: 50

Manus Aktteva

Tel: --
Fax: --
Email: info@manusaktteva.in
Country: India
ProdList: 581
Advantage: 34

Trignokem International

Tel: --
Fax: --
Country: India
ProdList: 110
Advantage: 58

ChemOrbit International

Tel: --
Fax: --
Email: 2014@gmail.com
Country: India
ProdList: 264
Advantage: 58

Opulent Pharma

Tel: --
Fax: --
Country: India
ProdList: 810
Advantage: 58

Pharma Affiliates

Tel: --
Fax: --
Email: @pharmaffiliates.com
Country: India
ProdList: 6754
Advantage: 58

Stereo Drugs Private Limited

Tel: --
Fax: --
Country: India
ProdList: 10
Advantage: 58

Bizten Impex Private Limited

Tel: --
Fax: --
Country: India
ProdList: 71
Advantage: 58

Manus Aktteva Biopharma LLP

Tel: --
Fax: --
Country: India
ProdList: 655
Advantage: 58

Oceanic Pharmachem Pvt. Ltd.

Tel: --
Fax: --
Email: info@oceanicpharmachem.com
Country: India
ProdList: 2005
Advantage: 58

Trignokem International.

Tel: --
Fax: --
Email: ignokem@gmail.com
Country: India
ProdList: 233
Advantage: 58

Bizten Impex Private Limited.

Tel: --
Fax: --
Country: India
ProdList: 109
Advantage: 58

Anant Pharmaceuticals Pvt. ltd

Tel: --
Fax: --
Email: info@anantlabs.com
Country: India
ProdList: 736
Advantage: 58

New Rise Life Science

Tel: --
Fax: --
Email: info@newriselifescience.com
Country: India
ProdList: 150
Advantage: 58

Gliesse Pharmaceuticals Pvt., Ltd.

Tel: --
Fax: --
Email: info@gliessepharma.com
Country: India
ProdList: 165
Advantage: 58

Clearsynth Labs

Tel: --
Fax: --
Email: fo@clearsynth.com
Country: India
ProdList: 3887
Advantage: 58

SynZeal Research Pvt Ltd

Tel: --
Fax: --
Email: standards@synzeal.com
Country: India
ProdList: 6514
Advantage: 58

Kkyemistry (india) Pvt., Ltd.

Tel: --
Fax: --
Email: marketing@kyemistryindia.com
Country: India
ProdList: 163
Advantage: 58

New Highway Medical

Tel: --
Fax: --
Country: India
ProdList: 1
Advantage: 58

NEW HARSH MEDICAL

Tel: --
Fax: --
Country: India
ProdList: 1
Advantage: 58

Fevikem Pharma

Tel: --
Fax: --
Country: India
ProdList: 2
Advantage: 58

Pharmaffiliates Analytics and Synthetics P. Ltd

Tel: --
Fax: --
Email: mktg@pharmaffiliates.com
Country: India
ProdList: 6739
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

Trignokem International

Tel: --
Fax: --
Email: info@trignokem.com
Country: India
ProdList: 380
Advantage: 50

More

Less

View Lastest Price from (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Posaconazole Intermediate 149809-43-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 500kgs
Release date: 2021-10-18

Shaanxi Dideu New Materials Co. Ltd

Product: (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester 149809-43-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000KGS
Release date: 2024-11-15

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: posaconazole impurity 13 149809-43-8
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-28

149809-43-8, (5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl esterRelated Search:

Folic acid Citric acid 5-Methyl-1H-benzotriazole Ethyl 2-(Chlorosulfonyl)acetate 1,2,4-Triazole Voriconazole Posaconazole 2-[(1S,2S)-1-ethyl-2-bezyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]- 3H-1,2,4-Triazol-3-one, 1H-Benzotriazole Ribavirin D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-(hydroxyMethyl)-1-(1H-1,2,4-triazol-1-yl)- Ascoric Acid Posaconazole Impurity 44 Posaconazole Impurity 17 Posaconazole iMpurity 4 Posaconazole DiastereoisoMer interMediate 2 PHENYL {4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL}CARBAMATE Posaconazole inter-8

Posaconazole Impurity 53

((3S,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate

Posaconazole InterMediates

2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-Methylphenyl)sulfonyl]oxy]Methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)Methyltetrahydrofuran-3-ylMethyl ester- (POA)

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4

Toluene-4-sulfonica cid 5-(2,4-difluoro-phenyl)-5-[1,2,4]triazol-1-ylMethyl-tetrahydro-furan-3-ylMethyl ester

((3R,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate

Posazonazole intermediate POA

[(3S,5R)-5-(2,4-difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-yl]methyl 4-methylbenzene-1-sulfonate

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)Methyltetrahydrofuran-3-ylMethyl esterChemicalBook

(5R-CIS) -Toluene-4-sulfonic acid 5- (2,4-difluorophenyl) -5- (1H-1,2,4-triazol-1-yl) methyl tetrahydrofuran-3- Methyl ester

((3R,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluo

Posaconazole Diastereoisomer Related Compound 8

4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl esterChemicalBook

4-difluorophenyl)-5-(1H-1

4-triazol-1-yl)Methyltetrahydrofuran-3-ylMethyl ester

(5R-cis)-Toluene-4-sulfonic acid 5-(2

Posaconazole InterMediate

Posaconazole inter-1

(5R-cis)-Toluene-4-sulfonic acid

Posaconazole Main Ring

(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate

Posaconazole int1

Posaconazole Intermediate1

Posa-12 ((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-methylbenzenesulfonate

[(3S,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methyl 4-methylbenzenesulfonate

((3S,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)methyl

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

Posaconazole Tosyl Impurity

(3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl p-Toluenesulfonate &gt

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydr

D-threo-Pentitol, 2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[[(4-methylphenyl)sulfonyl]oxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)

((3S,5R)-5-((1H-1,2,4-triazol-1-yl)Methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)Methyl 4-Methylbenzenesulfonate (Posaconazole intermediate)

Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester

p-Toluenesulfonic Acid (3S,5R)-5-(2,4-Difluorophenyl)-5-[(1H-1,2,4-triazol-1-yl)methyl]oxolan-3-ylmethyl Ester

Posaconazole 149809-43-8

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofuran-3-ylmethyl ester ISO 9001：2015 REACH

Posaconazole main compound 1

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1...

((3S,5R)-5-((1H-1

US-DMF No.: 033193

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methyltetrahydrofur

((3S,5R)-5-((1H-1,2,4-Triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methyl 4-Toluene benzenesulfonate

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazo 1-yl)methyltetrahydrofuran-3-ylmethyl ester

((3S,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)-tetrahydrofuran-3-yl)methyl 4-

(5R-cis)-Toluene-4-sulfonic acid 5-(2,4-difluorophenyl)-5-(1H-1,2,4-triazol-1-yl)methy...

main intermediate of Posaconazole

Posaconazole A

(3S,5R)-5-(1,2,4-triazol-1-yl-methyl)-5-(2,4-difluorophenyl)-3-(tosyloxymethyl)tetrahydrofuran

Posaconazole Intermediate-A

posaconazole impurity 13

149809-43-8

C21H21F2N3O4S

Aromatics

Chiral Reagents

Intermediates