Fimasartan

Product Name: Fimasartan
CAS No.: 247257-48-3
Chemical Name: Fimasartan
Synonyms: Kanarb;BR-A-657;Fimasartan;Non-masartan;Fimasartan D4;Unii-p58222188p;KANARB; BR-A-657;Fimasartan(BR-A-657);FiMasartan USP/EP/BP;Fimasartan Impurity H
CBNumber: CB22128722
Molecular Formula: C27H31N7OS
Formula Weight: 501.65
MOL File: 247257-48-3.mol

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Fimasartan Property

Melting point:: >155°C (dec.)
Boiling point:: 693.0±65.0 °C(Predicted)
Density: 1.25
storage temp.: 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 4.16±0.10(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3256
Product name: Fimasartan
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $86.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3256
Product name: Fimasartan
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $280
Updated: 2024/03/01

TRC

Product number: F342040
Product name: Fimasartan
Packaging: 25mg
Price: $120
Updated: 2021/12/16

Usbiological

Product number: 450068
Product name: Fimasartan
Packaging: 5mg
Price: $312
Updated: 2021/12/16

ChemScene

Product number: CS-3509
Product name: Fimasartan
Purity: 98.04%
Packaging: 5mg
Price: $60
Updated: 2021/12/16

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Fimasartan Chemical Properties,Usage,Production

Description

Fimasartan is an angiotensin II receptor antagonist (ARB) drug employed in the treatment of both hypertension and heart failure. It has been found to be safe when administered with hydrochlorothiazide (a diuretic) in clinical trials. Fimasartan was initially approved September 9th, 2010 in South Korea and is marketed under the brand name Kanarb by Boryung Pharmaceuticals.

Uses

Fimasartan is a new angiotensin II receptor blocker antagonist and also functions as an antihypertensive agent.

Definition

ChEBI: Fimasartan is a member of biphenyls.

Biological Activity

Fimasartan (Kanarb) is a non-peptide angiotensin II receptor antagonist (ARB) with noncompetitive, insurmountable binding with the AT1 receptor. It is used for the treatment of hypertension and heart failure.

Mechanism of action

Angiotensin II activates AR1 leading to vasoconstriction and increased noradrenaline release which further increases vasoconstriction via action at α1-adrenergic receptors. It also stimulates secretion of aldosterone which acts to increase sodium and water reabsorption in the renal tubules. Fimasartan bind to and antagonizes AR1 preventing vasoconstriction and reducing aldosterone secretion to increase natriuresis leading to a reduction in blood volume. Together these effects produce an anti-hypertensive effect.

Fimasartan Preparation Products And Raw materials

Raw materials

Preparation Products

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Fimasartan Suppliers

China 153 China Hong Kong 1 India 8 United Kingdom 1 United States 12 Global 175

Carbosynth

Tel: --
Fax: --
Email: sales@carbosynth.com
Country: United Kingdom
ProdList: 6005
Advantage: 58

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View Lastest Price from Fimasartan manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: Fimasartan 247257-48-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-12

Zibo Wei Bin Import & Export Trade Co. Ltd.

Product: Fimasartan 247257-48-3
Price: US $0.00/kg
Min. Order: 0.1kg
Purity: 98%
Supply Ability: 30kg
Release date: 2023-12-08

Zhuhai Hairuide Bioscience and Technology Co., Ltd

Product: Fimasartan 247257-48-3
Price: US $0.00/KG Ton
Min. Order: 1KG Ton
Purity: 99.5%+
Supply Ability: 2 tons/month
Release date: 2022-10-09

247257-48-3, FimasartanRelated Search:

(S)-Indacaterol 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide Pyrazine Thiophanate-methyl Methyl acetate Bensulfuron methyl METSULFURON METHYL tert-Butyldimethylsilyl chloride Methyl acrylate Dithiooxamide Methylparaben N-(n-Butyl)thiophosphoric triamide Kresoxim-methyl Methyl 2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-4-Methyl-6-oxo-1,6-dihydropyriMidin-5-yl) -N,N-diMethylacetaMide 2-(2-butyl-4-hydroxy-6-MethylpyriMidin-5-yl)-N,N-diMethylacetaMide METHYL TRIPHENYLMETHYL ETHER 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one

Fimasartan

Unii-p58222188p

2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrim

2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide

2-(2-butyl-4-Methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methoxy)pyriMidin-5-yl)-N,N-diMethylacetaMide-yl)-N,N-diMethylacetaMide

BR-A-657

Kanarb

5-PyriMidineethanethioaMide,2-butyl-1,6-dihydro-N,N,4-triMethyl-6-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-

Fimasartan(BR-A-657)

2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide

Fimasartan Impurity H

KANARB; BR-A-657

2-[2-butyl-4-methyl-6-oxo-1-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrimidin-5-yl]-N,N-dimethylethanethioamide

2-(2-butyl-4-methyl-6-((2'-(1-trityl-1H-tetrazol-5-yl)-[ 1,1'-biphenyl]-4-yl)methoxy)pyrimidin-5-yl)-N,N- dimethylacetamide

FiMasartan USP/EP/BP

2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one USP/EP/BP

2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(1H-tetrazol-5-yl)- 4-biphenylyl]methyl}-1,6-dihydro-5-pyrimidinyl)- N,N-dimethylethanethioamide

Fimasartan D4

2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(1H-tetrazol-5-yl)-4-biphenylyl] methyl}-1,6-dihydro-5-pyrimidinyl)-N,N-dimethylethanethioamide (Fimasartan)

2-(1-((2'-(2H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide

2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)-N,N-dimethylethanethioamide

2-Butyl-5-dimethylaminothiocarbonylmethyl-6-methyl-3-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one

5-Pyrimidineethanethioamide, 2-butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

Non-masartan

247257-48-3

C27H31N7OS

Inhibitors

API