5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Product Name: 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole
CAS No.: 124750-51-2
Chemical Name: 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole
Synonyms: Losaint-B;ALSTint-A04;Valsartan IMP;Valsartan Impurity;Valsartan Impurity 8;Valsartan Impurity 9;TRITYLATED BROMO IMP;Fimasartan Impurity B;Valsartan impurity 19;Valsartan intermediate
CBNumber: CB8369024
Molecular Formula: C33H25BrN4
Formula Weight: 557.48
MOL File: 124750-51-2.mol

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5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Property

Melting point:: 152-155°C
Boiling point:: 61°C/12mmHg(lit.)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in Chloroform and Methanol (Sparingly)
form: Solid
pka: 0.29±0.10(Predicted)
color: White
Stability:: Moisture Sensitive
InChI: InChI=1S/C33H25BrN4/c34-24-25-20-22-26(23-21-25)30-18-10-11-19-31(30)32-35-36-37-38(32)33(27-12-4-1-5-13-27,28-14-6-2-7-15-28)29-16-8-3-9-17-29/h1-23H,24H2
InChIKey: ZTFVTXDWDFIQEU-UHFFFAOYSA-N
SMILES: N1(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C(C2=CC=CC=C2C2=CC=C(CBr)C=C2)=NN=N1
CAS DataBase Reference: 124750-51-2(CAS DataBase Reference)

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Safety

RIDADR: UN 2811 6.1/PG III
HazardClass: 6.1
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T137073
Product name: 5-(4'-(BROMOMETHYL)(1,1'-BIPHENYL)-2-YL)-1-TRITYL-1H-TETRAAZOLE
Purity: Aldrich
Packaging: 10mg
Price: $139
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FB19245
Product name: 5-[4'-Bromomethyl-(1,1'-biphenyl)-2-yl]-1-triphenylmethyltetrazole
Packaging: 50g
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19245
Product name: 5-[4'-Bromomethyl-(1,1'-biphenyl)-2-yl]-1-triphenylmethyltetrazole
Packaging: 100g
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: J11478
Product name: OlmesartanImpurity20
Packaging: 100mg
Price: $95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB19245
Product name: 5-[4'-Bromomethyl-(1,1'-biphenyl)-2-yl]-1-triphenylmethyltetrazole
Packaging: 25g
Price: $100
Updated: 2021/12/16

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5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Chemical Properties,Usage,Production

Description

5-[4′-Bromomethyl-(1,1′-biphenyl)-2-yl]-1-triphenylmethyltetrazole is an intermediate in the synthesis of Losartan and Valsartan. Utilized for various purposes, 5-[4′-Bromomethyl-(1,1′-biphenyl)-2-yl]-1-triphenylmethyltetrazole has found application as a fluorescent probe to identify DNA damage. It serves as a photosensitizer in photodynamic therapy and acts as a catalyst in polymer synthesis. Furthermore, this compound functions as a fluorescent label to detect proteins and as a fluorescent indicator to detect metal ions.

Chemical Properties

Off-White Solid

Uses

Used as Olmesartan medoxomil related intermediate, Olmesartan medoxomil is an angiotensin II receptor antagonist^[1].

Application

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole is an important pharmaceutical intermediate. It can be used in the preparation of olmesartan medoxomil key intermediates, Losartan potassium, Valsartan, Candesartan and molecular sieve catalysts.

Hazard

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole has an acute toxin and is irritating to skin and eyes.

References

[1] HAI Z. Determination of the related substances in N-triphenylmethyl-5-(4’-bromomethylbiphenyl-2-yl-) terazole by HPLC[J]. West China Journal of Pharmaceutical Sciences, 2015.

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole Suppliers

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TaiZhou ZhiCheng Chemicals & Technology Co., LTD.

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View Lastest Price from 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole manufacturers

Hebei Dangtong Import and export Co LTD

Product: 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole 124750-51-2
Price: US $36.00-27.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000kg
Release date: 2023-09-19

Sinoway Industrial co., ltd.

Product: BBTT 124750-51-2
Price: US $0.00/KG
Min. Order: 2KG
Purity: 99% up, High Density
Supply Ability: 20 tons
Release date: 2021-09-09

Hangzhou ICH Biofarm Co., Ltd

Product: 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole 124750-51-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.0%min
Supply Ability: 10tons
Release date: 2023-07-12

124750-51-2, 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazoleRelated Search:

4,4'-Dimethylbiphenyl Decabromodiphenyl oxide FIREMASTER BP-6 Biphenyl 2-Bromobiphenyl 2,3,5-Triphenyltetrazolium chloride 2-(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-2-butyl-4-Methyl-6-oxo-1,6-dihydropyriMidin-5-yl) -N,N-diMethylacetaMide Fimasartan 2-Butyl-1,6-dihydro-N,N,4-trimethyl-6-oxo-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-5-pyrimidineacetamide 2-(2-butyl-4-hydroxy-6-MethylpyriMidin-5-yl)-N,N-diMethylacetaMide OlMesartan MedoxoMil iMpurity V N-Trityl Olmesartan Ethyl Ester METHYL TRIPHENYLMETHYL ETHER 2-(2-butyl-4-Methyl-6-oxo-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)Methyl)-1,6-dihydropyriMidin-5-yl)-N,N-diMethylethanethioaMide 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester Diethyl 2-propylImidazoledicarbonate OlMesartan MedoxoMil Butyl IMpurity 4,5-Dimethyl-1,3-dioxol-2-one

N-(Triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole

N-(TRIPHENYLMETHYL)-5-(4'-BROMOMETHYLBIPHENYL-2-YL) TETRAZOLE

5-(4'-BROMOMETHYL-1,1'-BIPHENYL-2-YL)-1-TRIPHENYLMETHYL-1H-TETRAZOLE

5-(4'-BROMOMETHYL-BIPHENYL-2-YL)-1-TRITYL-1H-TETRAZOLE

1H-Tetrazole, 5-[4'-(bromomethyl)[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)-

Trityl tetrazole bromomethyl biphenyl

5-(4'-(BROMOMETHYL)(1,1'-BIPHENYL)-2-YL)-1-TRITYL-

5-[4'-(Bromomethyl)[1,1'-Biphenyl]-1-(Triphenylmethyl)Tetrazole]

2-(N-Triphenylmethyltetrazolyl)-4-Bromomethylbiphenyl)97%

Valsartan intermediate

5-[4Bromomethyl-(1,1biphenyl)-2-yl]-1-triphenylmethyltetrazole

N-(TRIPHENYLMETHYL)-5-(4''-BROMOMETHYLBIPHENYL-2-YL-)TETRAZOLE(BBTT)

5-[4'-bromomethyl-1,1'-biphenyl-2-yl]-1-trityl-1H-tetrazole

(TRIPHENYLMETHYL)TETRAZOLE

Fimasartan Impurity B

Olmesartan Medoxomil Impurity 32

Olmesartan Medoxomil Impurity 30

N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole

intermediate of sartan drugs

Olmesartan Medoxomil-21

5-(4'-(BROMOMETHYL)(1,1'-BIPHENYL)-2-YL)-1-TRITYL-1H-TETRAAZOLE

N-(Triphenylmethyl)-5-(4’-bromomethylbiphenyl-2-yi-)tetrazole

N-(Triphenylmethyl)C5-(4'-Bromomethylbiphenyl-2Yl)Tetrazole

n-(triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole,N-(Triphenyl methyl)-5-(4'-Bromomethyl-biphenyl-2-yl)tetrazole(TTBB,BBTT)

5-(4'-BroMoMethyl-1,1'-biphenyl-2-yl)-1-triphenylM

5-[5-(broMoMethyl)-2-phenylphenyl]-1-(triphenylMethyl)-1H-1,2,3,4-tetrazole

Candesartan BroMo IMpurity：5-(4'-(BroMoMethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetrazole

[2'-(1-Trityl-1H-tetrazol-5-yl)biphenyl-4-yl]Methyl BroMide

4-[2'-(N-TriphenylMethyltetrazol-5-yl)phenyl]benzyl BroMide

4'-BroMoMethyl-2-(1-trityl-1H-tetrazol-5-yl)biphenyl

4-BroMoMethyl-2'-[N-triphenylMethyl-1H-tetrazol-5-yl]biphenyl

N-(Trityl)-5-(4'-BroMoMethyl Biphenyl-2-Yl)-Tetrazole

Irbesartan BroMo IMpurity

Olmesartan Impurity (N-(Triphenylmethyl)-5-(4’-bromomethylbiphenyl-2-yl)tetrazole)

5-{2-[4-(bromomethyl)phenyl]phenyl}-1-(triphenylmethyl)-1H-1,2,3,4-tetrazole

ALSTint-A04

Losaint-B

Olmesartan1 Impurity 28

N-(Triphenylmethyl)-5-(4’-bromomethylbiphenylyl)tetrazole

Losartan BroMo N1 Trityl IMpurity

Valsartan BroMo IMpurity

Irbesartan BroMo N1-Trityl IMpurity

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole N-(Triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole

OlMesartan IMpurity (N-(TriphenylMethyl)-5-(4'-broMoMethylbiphenylyl)tetrazole)

5-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetrazole 200mg Desbutoxy Valsartan Benzyl Ester

Candesartan Bromo N1-Trityl Impurity

Valsartan Impurity

N-(Tm)-5-(4'-bromomethylbiphenyl-2-yl ) tetrazole(TTBB)

Valsartan Impurity 8

Valsartan Impurity 9

Valsartan impurity 19

(R)-2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)propionamido)-3-methylbutanoic acid

Valsartan IMP

5-[4'-(Bromomethyl)-1,1'-biphenyl-2-yl]-1-triphenylmethyl-1H-tetrazole&gt

Irbesartan Bromo N2-Trityl Impurity

5-(4'-Bromomethyl-1,1'- biphenyl-2-yl)-1- triphenylmethyl-1Htetrazole （BBTT）

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole USP/EP/BP

1-Triphenylmethyl-5-[4'-(bromomethyl)biphenyl-2-yl]tetrazole DISCONTINUED, offer B685310