ChemicalBook > CAS DataBase List > 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride

1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride

Product Name
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
CAS No.
203911-27-7
Chemical Name
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
Synonyms
HA-1077 (hydrochloride);HA-1077 dihydrochloride solid, >=98% (HPLC);Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:2);1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride;1-(5-Isoquinolinesulphonyl)homopiperazine dihydrochloride salt, Fausidil dihydrochoride salt;HA-1077 dihydrochloride,1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
CBNumber
CB22129608
Molecular Formula
C14H17N3O2S.2ClH.H2O
Formula Weight
382.31
MOL File
203911-27-7.mol
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1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Property

Density 
1.289
RTECS 
HM4031166
Flash point:
260℃
storage temp. 
Store at -20°C
solubility 
H2O: >10mg/mL
form 
solid
color 
white to off-white
Water Solubility 
Soluble in water and dimethylsulfoxide.
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H139
Product name
HA-1077 dihydrochloride
Purity
solid, ≥98% (HPLC)
Packaging
5mg
Price
$403
Updated
2024/03/01
Sigma-Aldrich
Product number
H139
Product name
HA-1077 dihydrochloride
Purity
solid, ≥98% (HPLC)
Packaging
10mg
Price
$631
Updated
2024/03/01
Alfa Aesar
Product number
J60594
Product name
Fasudil dihydrochloride, 99+%
Packaging
250mg
Price
$187.65
Updated
2024/03/01
Alfa Aesar
Product number
J60594
Product name
Fasudil dihydrochloride, 99+%
Packaging
1g
Price
$632.65
Updated
2024/03/01
Cayman Chemical
Product number
10010559
Product name
HA-1077 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$44
Updated
2024/03/01
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1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Chemical Properties,Usage,Production

Description

Rho-associated kinase (ROCK), an effector of the small GTP-binding protein Rho, plays an important role in various cellular functions including vascular smooth muscle contraction, proliferation, and migration as well as inflammatory cell mobility. HA-1077 is a potent inhibitor of ROCK2 and additionally inhibits protein kinase c-related kinase 2 (PRK2), mitogen- and stress-activated protein kinase (MSK1), and mitogen activated protein kinase-activated protein kinase 1b (MAPKAP-K1b) with IC50 values of 1.9, 4, 5, and 15 μM, respectively. By inhibiting the activity of ROCK, HA-1077 has been shown to reduce blood vessel constriction, decrease pulmonary arterial pressure, inhibit tumor angiogenesis, and improve insulin signaling in various rodent models. While originally marketed for the prevention of cerebral vasospasm in patients with subarachnoid hemorrhage, oral formulations of HA-1077 are used for the treatment of a wide range of cardiovascular diseases including pulmonary arterial hypertension and stable angina.

Chemical Properties

White fine crystalline powder

Uses

Fasudil dihydrochloride is used in the inhibition of contractile responses to potassium chloride, phenylephnne (PHE), prostaglandin and hepatic stellate cells spreading. It is also used in the formation of stress fibers and in medicine.

Uses

HA-1077 dihydrochloride has been used:

  • to relax cantilevers
  • in the functional assessment of isolated coronary arteries
  • to investigate the effect of azaindole-1, fasudil on acute hypoxic pulmonary vasoconstriction (HPV)

Biochem/physiol Actions

Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca2+ antagonist.

1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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jkinfo@jkchemical.com
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China
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AdooQ BioScience, LLC
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+1 (866) 333-9607
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021-61478794
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China
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Sigma-Aldrich
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Shanghai QianYan Bio-technology Co., Ltd
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02781293128
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orders@biochemsafebuy.com
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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View Lastest Price from 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride manufacturers

Career Henan Chemical Co
Product
1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride 203911-27-7
Price
US $1.00/g
Min. Order
1g
Purity
95-99%
Supply Ability
1ton
Release date
2020-01-10

203911-27-7, 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochlorideRelated Search:


  • 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
  • HA-1077 dihydrochloride,1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
  • HA-1077 (hydrochloride)
  • 1-(5-Isoquinolinesulphonyl)homopiperazine dihydrochloride salt, Fausidil dihydrochoride salt
  • HA-1077 dihydrochloride solid, >=98% (HPLC)
  • Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:2)
  • 203911-27-7
  • Inhibitor