ChemicalBook > CAS DataBase List > 2,6-Dibromo-4-methoxypyridine
2,6-Dibromo-4-methoxypyridine
- Product Name
- 2,6-Dibromo-4-methoxypyridine
- CAS No.
- 117873-72-0
- Chemical Name
- 2,6-Dibromo-4-methoxypyridine
- Synonyms
- 2,6-Dibromo-4-methoxypyridine;Pyridine,2,6-dibromo-4-methoxy-;2,6-Dibromo-4-methoxypyridine 99%
- CBNumber
- CB22129769
- Molecular Formula
- C6H5Br2NO
- Formula Weight
- 266.92
- MOL File
- 117873-72-0.mol
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2,6-Dibromo-4-methoxypyridine Property
- Melting point:
- 136 °C(Solv: ethanol (64-17-5); water (7732-18-5))
- Boiling point:
- 283.0±35.0 °C(Predicted)
- Density
- 1.919±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- crystalline solid
- pka
- -2.35±0.10(Predicted)
- color
- Lemon
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Safety
- HS Code
- 2933399990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TRC
- Product number
- D426623
- Product name
- 2,6-Dibromo-4-methoxypyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H56-9-2M
- Product name
- 2,6-Dibromo-4-methoxypyridine
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
Oakwood
- Product number
- 321417
- Product name
- 2,6-Dibromo-4-methoxypyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD55742
- Product name
- 2,6-Dibromo-4-methoxypyridine
- Packaging
- 250mg
- Price
- $105
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FD55742
- Product name
- 2,6-Dibromo-4-methoxypyridine
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
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2,6-Dibromo-4-methoxypyridine Chemical Properties,Usage,Production
Uses
2,6-Dibromo-4-methoxypyridine is a useful reactant for the preparation of various organic compounds such as pyridine-pyridone alternate oligomers, and cyclic adenosine monophosphate.
Synthesis
2408-70-0
124-41-4
117873-72-0
Reaction of 2,4,6-tribromopyridine (5) and sodium methanol (1.2 eq.) under methanol reflux conditions afforded 2,6-dibromo-4-methoxypyridine (6) in 80% yield. Subsequently, the compound (6) was treated with n-butyllithium (1.2 eq.) at -78 °C and reacted with pivaleronitrile (1.2 eq.) for 150 min, followed by refluxing in two conventional sulfuric acids for 2 h to afford the keto isomer (7) in 86% yield. Compound (7) was converted to optically active alcohol (8) in 93% yield and 90% optical purity by hydrogen transfer type asymmetric reduction catalyzed by asymmetric ruthenium catalyst RuCl[(S,S)-Tddpen] (p-isopropylbenzene, 0.01 equiv.) using formic acid (4.3 equiv.) and triethylamine (2.5 equiv.). Next, compound (8) was converted to a camphor ester using a chloride, processed for optical splitting by recrystallization (75% yield, diastereoisomer ratio = 99/<1), and saponified again to give an almost optically pure alcohol (7, quantitatively). Finally, homogeneous coupling of compound (7) using palladium catalyst [PdCl2(PhCN)2-TDAE] afforded the pyridine isomer (9) (chemical formula 5) in 36% yield (diastereoisomer ratio = >99.5/<0.5).
References
[1] Patent: EP1724251, 2006, A1. Location in patent: Page/Page column 5; 9
2,6-Dibromo-4-methoxypyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dibromo-4-methoxypyridine manufacturers
Career Henan Chemical Co
- Product
- 2,6-Dibromo-4-methoxypyridine 117873-72-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-07
117873-72-0, 2,6-Dibromo-4-methoxypyridineRelated Search:
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