2-Amino-4-chlorobenzaldehyde
- Product Name
- 2-Amino-4-chlorobenzaldehyde
- CAS No.
- 59236-37-2
- Chemical Name
- 2-Amino-4-chlorobenzaldehyde
- Synonyms
- 2-Amino-4-chlorobenzaldehyde;Benzaldehyde, 2-amino-4-chloro-;Benzo[i]dipyrido[3,2-a:2',5'-c]phenazine
- CBNumber
- CB22136347
- Molecular Formula
- C7H6ClNO
- Formula Weight
- 155.58
- MOL File
- 59236-37-2.mol
2-Amino-4-chlorobenzaldehyde Property
- Boiling point:
- 297.0±25.0 °C(Predicted)
- Density
- 1.348±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.70±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2922390090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A587050
- Product name
- 2-Amino-4-chlorobenzaldehyde
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- A587050
- Product name
- 2-Amino-4-chlorobenzaldehyde
- Packaging
- 1g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- A587050
- Product name
- 2-Amino-4-chlorobenzaldehyde
- Packaging
- 2.5g
- Price
- $605
- Updated
- 2021/12/16
- Product number
- 6140CS
- Product name
- 2-Amino-4-chlorobenzaldehyde
- Packaging
- 250mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- FA139367
- Product name
- 2-Amino-4-chlorobenzaldehyde
- Packaging
- 250mg
- Price
- $227.5
- Updated
- 2021/12/16
2-Amino-4-chlorobenzaldehyde Chemical Properties,Usage,Production
Uses
2-Amino-4-chlorobenzaldehyde is a reagent used in the synthesis of pharmaceuticals such as robenidine analogues which are active against MRSA and VRE.
Synthesis
37585-16-3
59236-37-2
General procedure for the synthesis of 2-amino-4-chlorobenzaldehyde from (2-amino-4-chlorophenyl)methanol: In a 2L three-necked round-bottomed flask, (2-amino-4-chlorophenyl)methanol (32 g, 203.82 mmol) was dissolved in dichloromethane (765 mL), and manganese dioxide (150 g, 1.724 mol) was slowly added under stirring. The reaction mixture was stirred continuously for 40 hours at room temperature and under argon protection. Upon completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad and the solid residue was washed well with dichloromethane (1000 mL). The filtrates were combined and concentrated under reduced pressure to give 2-amino-4-chlorobenzaldehyde as an orange solid. Yield: 24 g (76.2% yield).
References
[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 19, p. 5810 - 5831
[2] ChemistryOpen, 2015, vol. 4, # 2, p. 107 - 110
[3] Angewandte Chemie - International Edition, 2017, vol. 56, # 35, p. 10573 - 10576
[4] Angew. Chem., 2017, vol. 129, # 35, p. 10709 - 10712,4
[5] Synlett, 2017, vol. 28, # 14, p. 1724 - 1728
2-Amino-4-chlorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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