4'-Hydroxyphenyl Carvedilol

Product Name: 4'-Hydroxyphenyl Carvedilol
CAS No.: 142227-49-4
Chemical Name: 4'-Hydroxyphenyl Carvedilol
Synonyms: (R)-BM 14686;(S)-BM 14686;(S)-BM 140686;(R)-BM 140686;4-Hydroxycarvedilol;Carvedilol Impurity 12;(R)-4-Hydroxycarvedilol;(S)-4-Hydroxycarvedilol;4'-Hydroxyphenyl carvedilol;4'-hydroxyphenyl Carvedilol
CBNumber: CB2214210
Molecular Formula: C24H26N2O5
Formula Weight: 422.47
MOL File: 142227-49-4.mol

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4'-Hydroxyphenyl Carvedilol Property

Melting point:: 163-165°C
Boiling point:: 702.0±60.0 °C(Predicted)
Density: 1.305±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.94±0.20(Predicted)
color: White to Light Brown
InChI: 1S/C24H26N2O5/c1-29-23-13-16(27)9-10-21(23)30-12-11-25-14-17(28)15-31-22-8-4-7-20-24(22)18-5-2-3-6-19(18)26-20/h2-10,13,17,25-28H,11-12,14-15H2,1H3
InChIKey: ZCJHEORDHXCJNB-UHFFFAOYSA-N
SMILES: [nH]1c2c(c4c1cccc4)c(ccc2)OCC(O)CNCCOc3c(cc(cc3)O)OC

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Safety

WGK Germany: WGK 3
HS Code: 9999999999
Storage Class: 11 - Combustible Solids
Hazard Classifications: Aquatic Chronic 2
STOT RE 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SMB00928
Product name: 4′-Hydroxy carvedilol
Packaging: 1MG
Price: $75.2
Updated: 2025/07/31

Sigma-Aldrich

Product number: SMB00928
Product name: 4′-Hydroxy carvedilol
Packaging: 5MG
Price: $290
Updated: 2025/07/31

Cayman Chemical

Product number: 27172
Product name: 4''-hydroxyphenyl Carvedilol
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 27172
Product name: 4''-hydroxyphenyl Carvedilol
Packaging: 5mg
Price: $356
Updated: 2024/03/01

TRC

Product number: H949120
Product name: 4’-HydroxyphenylCarvedilol
Packaging: 2mg
Price: $135
Updated: 2021/12/16

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4'-Hydroxyphenyl Carvedilol Chemical Properties,Usage,Production

Description

4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity. It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6. 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.

Chemical Properties

Off-White Solid

Uses

A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.

Uses

4'-Hydroxyphenyl Carvedilol is an optically active metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.

Uses

An optically active metabolite of Carvedilol (C184625), a nonselective ?-adrenergic blocker with α1-blocking activity.

Definition

ChEBI: 4'-Hydroxyphenyl Carvedilol is a member of carbazoles.

References

[1] DAXESH P. PATEL. UPLC-MS/MS assay for the simultaneous quantification of carvedilol and its active metabolite 4′-hydroxyphenyl carvedilol in human plasma to support a bioequivalence study in healthy volunteers[J]. Biomedical Chromatography, 2013, 27 8: 974-986. DOI: 10.1002/bmc.2889
[2] H G OLDHAM S E C. In vitro identification of the human cytochrome P450 enzymes involved in the metabolism of R(+)- and S(-)-carvedilol.[J]. Drug Metabolism and Disposition, 1997, 25 8: 970-977.
[3] THOMAS C MALIG. Comparison of free-radical inhibiting antioxidant properties of carvedilol and its phenolic metabolites.[J]. MedChemComm, 2017: 606-615. DOI: 10.1039/c7md00014f

4'-Hydroxyphenyl Carvedilol Preparation Products And Raw materials

Raw materials

Preparation Products

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4'-Hydroxyphenyl Carvedilol Suppliers

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142227-49-4, 4'-Hydroxyphenyl CarvedilolRelated Search:

SB 209995 Carvedilol Ketone Impurity Carvedilol Metoprolol tartrate Benazepril 8-Hydroxy Carvedilol Carvedilol Bisalkylpyrocatechol IMpurity 4'-HYDROXYPHENYL CARVEDILOL 5'-HYDROXYPHENYL CARVEDILOL (S)-(-)-5'-HYDROXYPHENYL-CARVEDILOL (R)-(+)-5'-HYDROXYPHENYL CARVEDILOL 4'-HYDROXYPHENYL CARVEDILOL-D5 (S)-(-)-4'-BENZYLOXYPHENYLOXY-CARVEDILOL 4'-HYDROXYPHENYLCARVEDILOL-D3 4'-BENZYLOXY-CARVEDILOL (R)-(+)-4'-BENZYLOXY-CARVEDILOL 4'-Hydroxyphenyl Carvedilol

(R)-(+)-4'-HYDROXYPHENYL-CARVEDILOL

(S)-(-)-4'-HYDROXYPHENYL-CARVEDILOL

(R)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol

(R)-4-Hydroxycarvedilol

(R)-BM 140686

(R)-BM 14686

(S)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol

(S)-4-Hydroxycarvedilol

(S)-BM 140686

(S)-BM 14686

4-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]aMino]ethoxy]-3-Methoxyphenol

Carvedilol 4-Hydroxy Metabolite

Carvedilol Impurity 12

Carvedilol metabolite 4-Hydroxyphenyl Carvedilol

4-Hydroxycarvedilol

Phenol, 4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxy-

4’-Hydroxyphenyl Carvedilol (10mM in DMSO)

4-Hydroxyphenyl CarvedilolQ: What is 4-Hydroxyphenyl Carvedilol Q: What is the CAS Number of 4-Hydroxyphenyl Carvedilol Q: What is the storage condition of 4-Hydroxyphenyl Carvedilol Q: What are the applications of 4-Hydroxyphenyl Carvedilol

4-(2-((3-((9H-Carbazol-4-yl)oxy)-2-hydroxypropyl)amino)ethoxy)-3-methoxyphenol (Carvedilol Impurity)

4'-Hydroxyphenyl carvedilol

4'-hydroxyphenyl Carvedilol

142227-49-4

C24H26N2O5

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