ChemicalBook > CAS DataBase List > 4'-Hydroxyphenyl Carvedilol

4'-Hydroxyphenyl Carvedilol

Product Name
4'-Hydroxyphenyl Carvedilol
CAS No.
142227-49-4
Chemical Name
4'-Hydroxyphenyl Carvedilol
Synonyms
(R)-BM 14686;(S)-BM 14686;(S)-BM 140686;(R)-BM 140686;4-Hydroxycarvedilol;Carvedilol Impurity 12;(R)-4-Hydroxycarvedilol;(S)-4-Hydroxycarvedilol;4'-HYDROXYPHENYL CARVEDILOL;4'-Hydroxyphenyl carvedilol
CBNumber
CB2214210
Molecular Formula
C24H26N2O5
Formula Weight
422.47
MOL File
142227-49-4.mol
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4'-Hydroxyphenyl Carvedilol Property

Melting point:
163-165°C
Boiling point:
702.0±60.0 °C(Predicted)
Density 
1.305±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
9.94±0.20(Predicted)
color 
White to Light Brown
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Safety

HS Code 
9999999999
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB00928
Product name
4′-Hydroxy carvedilol
Packaging
1MG
Price
$70.3
Updated
2024/03/01
Sigma-Aldrich
Product number
SMB00928
Product name
4′-Hydroxy carvedilol
Packaging
5MG
Price
$282
Updated
2024/03/01
Cayman Chemical
Product number
27172
Product name
4''-hydroxyphenyl Carvedilol
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
27172
Product name
4''-hydroxyphenyl Carvedilol
Packaging
5mg
Price
$356
Updated
2024/03/01
TRC
Product number
H949120
Product name
4’-HydroxyphenylCarvedilol
Packaging
2mg
Price
$135
Updated
2021/12/16
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4'-Hydroxyphenyl Carvedilol Chemical Properties,Usage,Production

Description

4’-hydroxyphenyl Carvedilol is a metabolite of carvedilol that is a more potent β-adrenergic receptor antagonist than carvedilol but has weaker vasodilatory activity. It is formed through oxidation primarily by the cytochrome P450 (CYP) isoform CYP2D6. 4’-hydroxyphenyl Carvedilol inhibits the formation of DPPH radicals in a cell-free assay.

Chemical Properties

Off-White Solid

Uses

A metabolite of Carvedilol (C184625). It is used in the treatment of hypertension.

Uses

4'-Hydroxyphenyl Carvedilol is an optically active metabolite of Carvedilol which is a multiple-action, neurohormonal antagonist that is used in the treatment of hypertension.

Uses

An optically active metabolite of Carvedilol (C184625), a nonselective ?-adrenergic blocker with α1-blocking activity.

Definition

ChEBI: 4'-Hydroxyphenyl Carvedilol is a member of carbazoles.

4'-Hydroxyphenyl Carvedilol Preparation Products And Raw materials

Raw materials

Preparation Products

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142227-49-4, 4'-Hydroxyphenyl CarvedilolRelated Search:

SB 209995 Carvedilol Ketone Impurity Carvedilol Metoprolol tartrate Benazepril 8-Hydroxy Carvedilol Carvedilol Bisalkylpyrocatechol IMpurity 4'-HYDROXYPHENYL CARVEDILOL 5'-HYDROXYPHENYL CARVEDILOL (S)-(-)-5'-HYDROXYPHENYL-CARVEDILOL (R)-(+)-5'-HYDROXYPHENYL CARVEDILOL 4'-HYDROXYPHENYL CARVEDILOL-D5 (S)-(-)-4'-BENZYLOXYPHENYLOXY-CARVEDILOL 4'-HYDROXYPHENYLCARVEDILOL-D3 4'-BENZYLOXY-CARVEDILOL (R)-(+)-4'-BENZYLOXY-CARVEDILOL 4'-Hydroxyphenyl Carvedilol

  • (R)-(+)-4'-HYDROXYPHENYL-CARVEDILOL
  • (S)-(-)-4'-HYDROXYPHENYL-CARVEDILOL
  • (R)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol
  • (R)-4-Hydroxycarvedilol
  • (R)-BM 140686
  • (R)-BM 14686
  • (S)-4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxyphenol
  • (S)-4-Hydroxycarvedilol
  • (S)-BM 140686
  • (S)-BM 14686
  • 4-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]aMino]ethoxy]-3-Methoxyphenol
  • Carvedilol 4-Hydroxy Metabolite
  • Carvedilol Impurity 12
  • Carvedilol metabolite 4-Hydroxyphenyl Carvedilol
  • 4'-HYDROXYPHENYL CARVEDILOL
  • 4-Hydroxycarvedilol
  • Phenol, 4-[2-[[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-3-methoxy-
  • 4’-Hydroxyphenyl Carvedilol (10mM in DMSO)
  • 4-Hydroxyphenyl CarvedilolQ: What is 4-Hydroxyphenyl Carvedilol Q: What is the CAS Number of 4-Hydroxyphenyl Carvedilol Q: What is the storage condition of 4-Hydroxyphenyl Carvedilol Q: What are the applications of 4-Hydroxyphenyl Carvedilol
  • 4-(2-((3-((9H-Carbazol-4-yl)oxy)-2-hydroxypropyl)amino)ethoxy)-3-methoxyphenol (Carvedilol Impurity)
  • 4'-Hydroxyphenyl carvedilol
  • 142227-49-4
  • C24H26N2O5
  • Metabolite
  • Aromatics
  • Heterocycles
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals