ChemicalBook > CAS DataBase List > 4-Methoxyfuro[2,3-b]quinolin-8-ol

4-Methoxyfuro[2,3-b]quinolin-8-ol

Product Name
4-Methoxyfuro[2,3-b]quinolin-8-ol
CAS No.
2255-50-7
Chemical Name
4-Methoxyfuro[2,3-b]quinolin-8-ol
Synonyms
Robustine;NPLC 0314;8-Hydroxydictamnine;8-hydroxy dictanmnine;Robustine (Haplophyllum);4-Methoxyfuro[2,3-b]quinolin-8-ol;Furo[2,3-b]quinolin-8-ol, 4-methoxy-;alkaloid,phosphodiesterase,Phosphodiesterase (PDE),Robustine,PDE5A,inhibit,Inhibitor
CBNumber
CB22149972
Molecular Formula
C12H9NO3
Formula Weight
215.2
MOL File
2255-50-7.mol
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4-Methoxyfuro[2,3-b]quinolin-8-ol Property

Melting point:
148-149℃ (ethanol )
Boiling point:
411.9±40.0 °C(Predicted)
Density 
1.378±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
form 
Solid
pka
5.34±0.30(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0016751
Product name
Robustine
Purity
99.95%
Packaging
5mg
Price
$375
Updated
2021/12/16
ChemScene
Product number
CS-0016751
Product name
Robustine
Purity
99.95%
Packaging
10mg
Price
$635
Updated
2021/12/16
ChemScene
Product number
CS-0016751
Product name
Robustine
Purity
99.95%
Packaging
1mg
Price
$150
Updated
2021/12/16
Arctom
Product number
CFN96362
Product name
Robustine
Purity
≥98%
Packaging
5mg
Price
$288
Updated
2021/12/16
AvaChem
Product number
3427
Product name
8-Hydroxy dictanmnine
Packaging
1mg
Price
$290
Updated
2021/12/16
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4-Methoxyfuro[2,3-b]quinolin-8-ol Chemical Properties,Usage,Production

Description

Haplophyllum robustum Bge. yields this alkaloid which forms colourless crystals from EtOH. It forms a series of crystalline salts and derivatives including the hydrochloride, m.p. 199-200°C; picrate, m.p. I 79-180°C; acetyl derivative, m.p.174-5°C; methyl derivative, m.p. 140-2°C and the tetrahydrG compound with m.p.201-2°C.

Uses

Robustine, a furoquinoline alkaloid, from Dictamnus albus, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro[1].

Definition

ChEBI: A quinoline alkaloid that is furo[2,3-b]quinoline substituted by a methoxy and a hydroxy group at positions 4 and 8 respectively.

IC 50

PDE5A

References

Fakhritdinova, Sidyakin, Yunusov,Khim. Prir.Soedin., 1, 107 (1965)
Faizutdinova, Yunusov, ibid, 3, 260 (1967)
Narasimhan, Paradkar, Alurkar, Tetrahedron, 27,1351 (1971)

4-Methoxyfuro[2,3-b]quinolin-8-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Methoxyfuro[2,3-b]quinolin-8-ol manufacturers

R&D Scientific Inc.
Product
Robustine 2255-50-7
Price
US $3500.00/g
Min. Order
1g
Purity
98
Supply Ability
50 Kg
Release date
2024-11-28
Career Henan Chemical Co
Product
4-Methoxyfuro[2,3-b]quinolin-8-ol 2255-50-7
Price
US $9.80/KG
Min. Order
1g
Purity
＞98%
Supply Ability
20 tons
Release date
2020-02-10

2255-50-7, 4-Methoxyfuro[2,3-b]quinolin-8-olRelated Search:

Cevadine veratramine Butyl stearate 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one Xanthiside Daurinoline FRAXINELLONE OBACUNON menisdaurin gamma-fagarine DICTAMNINE L-Hyoscyamine Xanthiazone VERATRIDINE daurisoline

  • 4-Methoxyfuro[2,3-b]quinolin-8-ol
  • Robustine
  • 8-Hydroxydictamnine
  • NPLC 0314
  • Robustine (Haplophyllum)
  • 8-hydroxy dictanmnine
  • Furo[2,3-b]quinolin-8-ol, 4-methoxy-
  • alkaloid,phosphodiesterase,Phosphodiesterase (PDE),Robustine,PDE5A,inhibit,Inhibitor
  • 2255-50-7
  • Alkaloids