SERTINDOLE
- Product Name
- SERTINDOLE
- CAS No.
- 106516-24-9
- Chemical Name
- SERTINDOLE
- Synonyms
- S-1991;Zerdol;Serlect;Serdoleet;LU-23-174;Serdolect;SERTINDOLE;Sertindole>SUBSTANCE 5364890;SERTINDOLE USP/EP/BP
- CBNumber
- CB2221267
- Molecular Formula
- C24H26ClFN4O
- Formula Weight
- 440.94
- MOL File
- 106516-24-9.mol
SERTINDOLE Property
- Melting point:
- 95-100°C
- Boiling point:
- 592.1±50.0 °C(Predicted)
- Density
- 1.36
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: >10mg/mL
- form
- solid
- pka
- 14.53±0.20(Predicted)
- color
- off-white
- Merck
- 14,8466
- InChIKey
- GZKLJWGUPQBVJQ-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S0942
- Product name
- Sertindole
- Purity
- >95.0%(HPLC)
- Packaging
- 10mg
- Price
- $135
- Updated
- 2024/03/01
- Product number
- S0942
- Product name
- Sertindole
- Purity
- >95.0%(HPLC)
- Packaging
- 50mg
- Price
- $528
- Updated
- 2024/03/01
- Product number
- 23883
- Product name
- Sertindole
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 23883
- Product name
- Sertindole
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- S279500
- Product name
- Sertindole
- Packaging
- 50mg
- Price
- $525
- Updated
- 2021/12/16
SERTINDOLE Chemical Properties,Usage,Production
Description
Serdolect was launched in the UK for acute and chronic schizophrenia and schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l- (4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain and has a high affinity for the serotinin 5-HT2 receptor where it behaves as an antagonist. It has weak affinity for the α1-adrenergic receptor and no affinity for dopamine D2 receptors. It is as effective as haloperidol but without the extrapyramidal symptoms. This may be a consequence of the fact that it expresses the c-fos protein in a manner different for haloperidol but similar to clozapine. It is non-sedating, long lasting (several days after a single dose) and has an atypical mode of action.
Description
Sertindole is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively). It also binds to histamine H1 and α1- and α2-adrenergic receptors (Kds = 320, 3.9, and 190 nM, respectively). In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats. Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats. It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice. Sertindole (0.02-0.32 mg/kg) also prevents accuracy deficits and anticipatory over-responding in the 5-choice serial reaction time task (5CSRTT) induced by the NMDA receptor antagonist (R)-CPP in rats. Formulations containing sertindole have been used in the treatment of schizophrenia.
Chemical Properties
Off-White to Pale Yellow Solid
Originator
Lundbeck (Denmark)
Uses
Antipsychotic used in the treatment of schizophrenia.
Uses
antipsychotic;Dopamine D2/Serotonin 5-HT2 receptor antagonist
Definition
ChEBI: A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-o oimidazolidin-1-yl)ethyl group.
brand name
SerLect (Abbott).
Side effects
Sertindole is an indole-containing compound that behaves as a high-affinity serotonin 5-HT2 receptor antagonist, with weak affinity for adrenergic α1 receptors and almost no affinity for dopaminergic D2 receptors. It is about as effective as haloperidol in the treatment of acute and chronic schizophrenia, but with much lower incidence of extrapyramidal side effects. Sertindole is relatively nonsedating, and its effects are long lasting (several days).
SERTINDOLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SERTINDOLE manufacturers
- Product
- SERTINDOLE 106516-24-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-23