SERTINDOLE

ChemicalBook > CAS DataBase List > SERTINDOLE

Product Name: SERTINDOLE
CAS No.: 106516-24-9
Chemical Name: SERTINDOLE
Synonyms: S-1991;Zerdol;Serlect;Serdoleet;LU-23-174;Serdolect;SERTINDOLE;Sertindole>SUBSTANCE 5364890;SERTINDOLE USP/EP/BP
CBNumber: CB2221267
Molecular Formula: C24H26ClFN4O
Formula Weight: 440.94
MOL File: 106516-24-9.mol

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SERTINDOLE Property

Melting point:: 95-100°C
Boiling point:: 592.1±50.0 °C(Predicted)
Density: 1.36
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: >10mg/mL
form: solid
pka: 14.53±0.20(Predicted)
color: off-white
Merck: 14,8466
InChIKey: GZKLJWGUPQBVJQ-UHFFFAOYSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
RTECS: NJ0621100
HS Code: 2933.99.6100

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: S0942
Product name: Sertindole
Purity: >95.0%(HPLC)
Packaging: 10mg
Price: $135
Updated: 2024/03/01

TCI Chemical

Product number: S0942
Product name: Sertindole
Purity: >95.0%(HPLC)
Packaging: 50mg
Price: $528
Updated: 2024/03/01

Cayman Chemical

Product number: 23883
Product name: Sertindole
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 23883
Product name: Sertindole
Purity: ≥98%
Packaging: 10mg
Price: $120
Updated: 2024/03/01

TRC

Product number: S279500
Product name: Sertindole
Packaging: 50mg
Price: $525
Updated: 2021/12/16

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SERTINDOLE Chemical Properties,Usage,Production

Description

Serdolect was launched in the UK for acute and chronic schizophrenia and schizoaffective psychoses. It is synthetically available in three steps from 5chloro-l- (4-fluorophenyl)-l H-indole. Sertindole is selective for the limbic areas of the brain and has a high affinity for the serotinin 5-HT₂ receptor where it behaves as an antagonist. It has weak affinity for the α₁-adrenergic receptor and no affinity for dopamine D₂ receptors. It is as effective as haloperidol but without the extrapyramidal symptoms. This may be a consequence of the fact that it expresses the c-fos protein in a manner different for haloperidol but similar to clozapine. It is non-sedating, long lasting (several days after a single dose) and has an atypical mode of action.

Description

Sertindole is an atypical antipsychotic that binds to dopamine D₂ receptors and the serotonin (5-HT) receptor subtypes 5-HT_1D, 5-HT_2A, and 5-HT_2C (K_ds = 2.7, 20, 0.14, and 6 nM, respectively). It also binds to histamine H₁ and α₁- and α₂-adrenergic receptors (K_ds = 320, 3.9, and 190 nM, respectively). In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats. Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats. It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice. Sertindole (0.02-0.32 mg/kg) also prevents accuracy deficits and anticipatory over-responding in the 5-choice serial reaction time task (5CSRTT) induced by the NMDA receptor antagonist (R)-CPP in rats. Formulations containing sertindole have been used in the treatment of schizophrenia.

Chemical Properties

Off-White to Pale Yellow Solid

Originator

Lundbeck (Denmark)

Uses

Antipsychotic used in the treatment of schizophrenia.

Uses

antipsychotic;Dopamine D2/Serotonin 5-HT2 receptor antagonist

Definition

ChEBI: A phenylindole that is 1H-indole which is substituted on the nitrogen by a p-chlorophenyl group, at position 5 by chlorine, and at position 3 by a piperidin-4-yl group, which is itself substituted on the nitrogen by a 2-(2-o oimidazolidin-1-yl)ethyl group.

brand name

SerLect (Abbott).

Side effects

Sertindole is an indole-containing compound that behaves as a high-affinity serotonin 5-HT2 receptor antagonist, with weak affinity for adrenergic α1 receptors and almost no affinity for dopaminergic D2 receptors. It is about as effective as haloperidol in the treatment of acute and chronic schizophrenia, but with much lower incidence of extrapyramidal side effects. Sertindole is relatively nonsedating, and its effects are long lasting (several days).

SERTINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from SERTINDOLE manufacturers

Dideu Industries Group Limited

Product: SERTINDOLE 106516-24-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-07-23

106516-24-9, SERTINDOLERelated Search:

Penfluridol CHEMBRDG-BB 4013121 5-CHLORO-1-METHYLINDOLE 5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOLE 1-(4-FLUOROPHENYL)PYRROLE 5-CHLORO-3-(1-METHYL-4-PIPERIDINYL)INDOLE N-(PIPERIDINOETHYL)ETHYLENEDIAMINE 5-CHLORO-1-(4-FLUORO-PHENYL)-3-PIPERIDIN-4-YL-1H-INDOLE 3-Piperidin-4-yl-1H-indole 3-(1-METHYL-4-PIPERIDINYL)INDOLE SERTINDOLE 1-(2-AMINOETHYL)-2-IMIDAZOLIDONE

SERTINDOLE

SERDOLECT;SERLECT;LU 23-174

Serlect

SUBSTANCE 5364890

1-(2-{4-[5-CHLORO-1-(4-FLUORO-PHENYL)-1H-INDOL-3-YL]-PIPERIDIN-1-YL}-ETHYL)-IMIDAZOLIDIN-2-ONE

1-[2-[4-[5-Chloro-1-(4-fluorophenyl)-1h-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone

1-(4-Fluorophenyl)-5-chloro-3-[1-[2-[(tetrahydro-2-oxo-1H-imidazol)-1-yl]ethyl]piperidin-4-yl]-1H-indole

1-[2-[4-[1-(4-Fluorophenyl)-5-chloro-1H-indole-3-yl]piperidino]ethyl]imidazolidine-2-one

S-1991

LU-23-174

Serdoleet

2-IMidazolidinone, Sertindole

2-IMidazolidinone,1-[2-[4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-

Zerdol

Serdolect

Sertindole&gt

SERTINDOLE USP/EP/BP

Maribavir Impurity 15

106516-24-9

C24H26ClFN4O

C24H26ClFN3O

C24H22D4ClFN4O

Aluminium foil bag/Fluoride bottle or on your request

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Isotope Labelled Compounds

Pharmaceuticals