SENEGENIN

ChemicalBook > CAS DataBase List > SENEGENIN

Product Name: SENEGENIN
CAS No.: 2469-34-3
Chemical Name: SENEGENIN
Synonyms: SENEGIN;SENEGENIN;Tenuigenin;Tenuifgenin;Senegenin-RM;Tenuifolic acid;Senegenin (6CI);Senegenin, >=98%;12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid;12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid
CBNumber: CB2222527
Molecular Formula: C30H45ClO6
Formula Weight: 537.13
MOL File: 2469-34-3.mol

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SENEGENIN Property

Melting point:: 290-292℃
alpha: D +19° (c = 0.70 in ethanol)
Boiling point:: 674.1±55.0 °C(Predicted)
Density: 1.28
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
pka: 4.27±0.70(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3
RTECS: RC8815000
Toxicity: LD50 intraperitoneal in mouse: 3mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1001
Product name: Senegenin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1001
Product name: Senegenin
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $464
Updated: 2023/06/20

Cayman Chemical

Product number: 28824
Product name: Tenuigenin
Packaging: 5mg
Price: $75
Updated: 2024/03/01

Cayman Chemical

Product number: 28824
Product name: Tenuigenin
Packaging: 100mg
Price: $975
Updated: 2024/03/01

Cayman Chemical

Product number: 28824
Product name: Tenuigenin
Packaging: 10mg
Price: $143
Updated: 2024/03/01

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SENEGENIN Chemical Properties,Usage,Production

Description

Tenuigenin is a triterpenoid sapogenin that has been found in P. tenuifolia and has diverse biological activities, including antioxidant, anti-inflammatory, and neuroprotective properties. It inhibits IL-1β and reactive oxygen species (ROS) production from LPS-induced mouse BV2 microglia at a concentration of 4 μM. Tenuigenin (25 mg/kg per day) decreases NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation and prevents dopaminergic neuronal degeneration in the mouse substantia nigra pars compacta in an MPTP-induced model of Parkinson''s disease. Tenuigenin (2 mg/kg) also reduces increases in lung edema and the levels of IL-1β and TNF-α in bronchoalveolar lavage fluid (BALF) in a mouse model of intranasal S. aureus-induced pneumonia.

Uses

Tenuifgenin is a Chinese herbal extract with anti-oxidative and anti-inflammatory effects involving toxin induced cell models of Parkinson’s disease.

Definition

ChEBI: Senegenin is a 12alpha-hydroxy steroid.

SENEGENIN Preparation Products And Raw materials

Raw materials

Preparation Products

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SENEGENIN Suppliers

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View Lastest Price from SENEGENIN manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: SENEGENIN 2469-34-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-22

Shanghai Standard Technology Co., Ltd.

Product: Senegenin 2469-34-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-24

Shanghai Standard Technology Co., Ltd.

Product: Senegenin 2469-34-3
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-09-24

2469-34-3, SENEGENINRelated Search:

Onjisaponin Z Polygalacic acid Sinegin 3 polygalaxanthone III Polygalacin D Polygalaxanthone XI Tenuifoliside C polygalic acid 1,11-Undecanedicarboxylic acid 2-DECYL-1-TETRADECANOL 1-Chlorooctadecane HEPTADECANEDIOIC ACID TRIPLAL Pentadecanedioic acid 3,3,5,5-TETRAMETHYLCYCLOHEXANOL 6-CHLORO-N-HEXANOIC ACID CETONAL 19-METHYLEICOSANOIC ACID

SENEGENIN

SENEGIN

13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid

28-dioicacid,12-(chloromethyl)-2-beta,3-beta-dihydroxy-27-noro-13-ene-2

27-Norolean-13-ene-23,28-dioicacid, 12-(chloromethyl)-2,3-dihydroxy-, (2β,3β,4α,12α)-

Tenuigenin

12α-(Chloromethyl)-2β,3β-dihydroxy-27-nor-5α-olean-13-ene-23,28-dioic acid

12α-Chloromethyl-2β,3β-dihydroxy-27-norolean-1-ene-23,28-dioic acid

Tenuifolic acid

(2beta,3beta,4alpha,12alpha)-12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid

12-(Chloromethyl)-2,3-dihydroxy-27-norolean-13-ene-23,28-dioic acid

Senegenin, >=98%

Tenuifgenin

(2S,3R,4S,4aR,6aR,8aS,12aS,13S,14aR,14bR)-13-(chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4a,5,6,7,8,9,10,12,12a,13,14,14a-tetradecahydro-1H-picene-4,8a-dicarboxylic acid

13-(Chloromethyl)-2,3-dihydroxy-4,6a,11,11,14b-pentamethyl-2,3,4,4a,5,6,6a,7,8,9,10,11,12,12a,13,14,14a,14b-octadecahydro-4,8a(1H)-picenedicarboxylic acid

Senegenin (6CI)

Senegenin-RM

2469-34-3

C30H45ClO6

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract