2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE
- Product Name
- 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE
- CAS No.
- 5221-37-4
- Chemical Name
- 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE
- Synonyms
- AKOS B015665;AKOS BBS-00004069;ART-CHEM-BB B015665;TIMTEC-BB SBB000164;2-(Chloroacetylamino)pyridine;N-(PYRID-2-YL)-CHLOROACETAMIDE;2-chloro-N-(2-pyridyl)acetamide;2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE;Acetamide, 2-chloro-N-2-pyridinyl-;2-chloro-N-pyridin-2-yl-ethanamide
- CBNumber
- CB2224031
- Molecular Formula
- C7H7ClN2O
- Formula Weight
- 170.6
- MOL File
- 5221-37-4.mol
2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE Property
- Melting point:
- 110 °C
- Boiling point:
- 378.1±22.0 °C(Predicted)
- Density
- 1.341±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 11.59±0.70(Predicted)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- C380643
- Product name
- 2-Chloro-N-pyridin-2-ylacetamide
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 011824
- Product name
- 2-Chloro-N-pyridin-2-yl-acetamide
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 011824
- Product name
- 2-Chloro-N-pyridin-2-yl-acetamide
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- OR939010
- Product name
- 2-Chloro-N-pyridin-2-ylacetamide
- Purity
- 95%
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 7349AB
- Product name
- 2-Chloro-N-pyridin-2-ylacetamide
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE Chemical Properties,Usage,Production
Synthesis
504-29-0
79-04-9
5221-37-4
1. Dissolve 2-aminopyridine (2.8 g, 30 mmol) in 50 mL of ethylene dichloride (25 mL) in a 50 mL glass container. 2. Slowly add chloroacetyl chloride dropwise to the above solution. 3. seal the glass vessel with a TFM Teflon lid and place it in the rotor of the microwave reactor. 4. Microwave irradiate the mixture for 5 minutes at 300 W power and 80 °C. 5. 5. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 9 with saturated aqueous sodium hydroxide solution. 6. The reaction mixture was extracted twice with dichloroethane. 7. The organic layers were combined and dried with anhydrous sodium sulfate. 8. The solvent was removed by rotary evaporator to give the crude product. 9. The crude product was recrystallized using acetonitrile to give 4.9 g (97% yield) of 2-chloro-N-pyridin-2-ylacetamide as a pink solid. 10. The melting point of the product is 110-115 °C. 11. The product was analyzed by IR (Kjeldahl). 11. The product was analyzed by IR (KBr) and showed characteristic absorption peaks at 3443, 3226, 1683, 1581, 1330, 1198, 775 cm-1. 12. 1H NMR (KBr) analysis showed the product to be in the range of 1H NMR (1H NMR, 1H NMR). 12. 1H NMR (CDCl3) data: δ 4.2 (2H, s), 7.1 (1H, d), 7.7 (1H, t), 8.2 (1H, d, J = 8.3 Hz), 8.4 (1H, d, J = 4.9 Hz), 8.95 (1H, bs). 13. 13C NMR (CDCl3) data: δ 43.2, 111.4, 121.0, 139.1, 148.2, 150.7, 164.9. 14. EIMS analysis showed a molecular ion peak m/z of 170.6 (M+).
References
[1] Patent: US2007/36715, 2007, A1. Location in patent: Page/Page column 4-5
[2] Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, vol. 31, p. 96 - 103
[3] Organic Letters, 2016, vol. 18, # 20, p. 5440 - 5443
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2060 - 2068
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 6, p. 2003 - 2010
2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE manufacturers
- Product
- 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE 5221-37-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08