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2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE

Product Name
2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE
CAS No.
5221-37-4
Chemical Name
2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE
Synonyms
AKOS B015665;AKOS BBS-00004069;ART-CHEM-BB B015665;TIMTEC-BB SBB000164;2-(Chloroacetylamino)pyridine;N-(PYRID-2-YL)-CHLOROACETAMIDE;2-chloro-N-(2-pyridyl)acetamide;2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE;Acetamide, 2-chloro-N-2-pyridinyl-;2-chloro-N-pyridin-2-yl-ethanamide
CBNumber
CB2224031
Molecular Formula
C7H7ClN2O
Formula Weight
170.6
MOL File
5221-37-4.mol
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2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE Property

Melting point:
110 °C
Boiling point:
378.1±22.0 °C(Predicted)
Density 
1.341±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
11.59±0.70(Predicted)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
C380643
Product name
2-Chloro-N-pyridin-2-ylacetamide
Packaging
50mg
Price
$45
Updated
2021/12/16
Matrix Scientific
Product number
011824
Product name
2-Chloro-N-pyridin-2-yl-acetamide
Packaging
500mg
Price
$65
Updated
2021/12/16
Matrix Scientific
Product number
011824
Product name
2-Chloro-N-pyridin-2-yl-acetamide
Packaging
1g
Price
$100
Updated
2021/12/16
Apolloscientific
Product number
OR939010
Product name
2-Chloro-N-pyridin-2-ylacetamide
Purity
95%
Packaging
1g
Price
$180
Updated
2021/12/16
AK Scientific
Product number
7349AB
Product name
2-Chloro-N-pyridin-2-ylacetamide
Packaging
1g
Price
$185
Updated
2021/12/16
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2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE Chemical Properties,Usage,Production

Synthesis

504-29-0

79-04-9

5221-37-4

1. Dissolve 2-aminopyridine (2.8 g, 30 mmol) in 50 mL of ethylene dichloride (25 mL) in a 50 mL glass container. 2. Slowly add chloroacetyl chloride dropwise to the above solution. 3. seal the glass vessel with a TFM Teflon lid and place it in the rotor of the microwave reactor. 4. Microwave irradiate the mixture for 5 minutes at 300 W power and 80 °C. 5. 5. Upon completion of the reaction, the pH of the reaction mixture was adjusted to 9 with saturated aqueous sodium hydroxide solution. 6. The reaction mixture was extracted twice with dichloroethane. 7. The organic layers were combined and dried with anhydrous sodium sulfate. 8. The solvent was removed by rotary evaporator to give the crude product. 9. The crude product was recrystallized using acetonitrile to give 4.9 g (97% yield) of 2-chloro-N-pyridin-2-ylacetamide as a pink solid. 10. The melting point of the product is 110-115 °C. 11. The product was analyzed by IR (Kjeldahl). 11. The product was analyzed by IR (KBr) and showed characteristic absorption peaks at 3443, 3226, 1683, 1581, 1330, 1198, 775 cm-1. 12. 1H NMR (KBr) analysis showed the product to be in the range of 1H NMR (1H NMR, 1H NMR). 12. 1H NMR (CDCl3) data: δ 4.2 (2H, s), 7.1 (1H, d), 7.7 (1H, t), 8.2 (1H, d, J = 8.3 Hz), 8.4 (1H, d, J = 4.9 Hz), 8.95 (1H, bs). 13. 13C NMR (CDCl3) data: δ 43.2, 111.4, 121.0, 139.1, 148.2, 150.7, 164.9. 14. EIMS analysis showed a molecular ion peak m/z of 170.6 (M+).

References

[1] Patent: US2007/36715, 2007, A1. Location in patent: Page/Page column 4-5
[2] Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, vol. 31, p. 96 - 103
[3] Organic Letters, 2016, vol. 18, # 20, p. 5440 - 5443
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 7, p. 2060 - 2068
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 6, p. 2003 - 2010

2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE Suppliers

China 47 France 1 Germany 3 India 2 Russia 4 Sweden 2 Ukraine 1 United Kingdom 2 United States 8 Global 70
AKos Consulting and Solutions GmbH
Tel
--
Fax
--
Email
akos@akosgmbh.eu
Country
Germany
ProdList
1061
Advantage
60
AKos Consulting & Solutions GmbH
Tel
--
Fax
--
Email
akos@akosgmbh.de
Country
Germany
ProdList
6717
Advantage
72
ChemCollect GmbH
Tel
--
Fax
--
Email
contact@chemcollect.de
Country
Germany
ProdList
6214
Advantage
54
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View Lastest Price from 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE manufacturers

Career Henan Chemical Co
Product
2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE 5221-37-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-08

5221-37-4, 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDERelated Search:

2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE 2-CHLORO-N-(5-CHLOROPYRIDIN-2-YL)ACETAMIDE N-(5-BROMOPYRIDIN-2-YL)-2-CHLOROACETAMIDE 3-CHLORO-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-(TRIFLUOROMETHYL)-2(1H)-PYRIDINONE 2-CHLORO-N-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]ACETAMIDE 2-CHLORO-N-(5-IODO-2-PYRIDINYL)ACETAMIDE 4-CHLORO-2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-PIPERAZINO-3(2H)-PYRIDAZINONE 4-CHLORO-2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-[(2-HYDROXYETHYL)(METHYL)AMINO]-3(2H)-PYRIDAZINONE 2-chloro-N-(3-methylpyridin-2-yl)acetamide 4-CHLORO-2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-5-MORPHOLINO-3(2H)-PYRIDAZINONE 4,5-DICHLORO-2-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-3(2H)-PYRIDAZINONE 2-CHLORO-N-(3-[(2,5-DIMETHYLBENZYL)OXY]-6-METHYLPYRIDIN-2-YL)ACETAMIDE ETHYL N-[3-(4-(5-CHLORO-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-6-OXO-1,6-DIHYDRO-4-PYRIDAZINYL)PIPERAZINO)-2-CYANOACRYLOYL]CARBAMATE 2-CHLORO-4-(2-([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]AMINO)ETHYL)PYRIDO[2,3-B]PYRAZIN-3(4H)-ONE AKOS BBS-00004071 2-CHLORO-N-(4-METHYLPYRIDIN-2-YL)ACETAMIDE 2-[(5-CHLORO-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-6-OXO-1,6-DIHYDRO-4-PYRIDAZINYL)(METHYL)AMINO]ETHYL 2,6-DIFLUOROBENZENECARBOXYLATE 1-((5-CHLORO-1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-6-OXO-1,6-DIHYDRO-4-PYRIDAZINYL)OXY)DIHYDRO-1H-PYRROLE-2,5-DIONE

  • N-(PYRID-2-YL)-CHLOROACETAMIDE
  • TIMTEC-BB SBB000164
  • 2-chloro-N-(2-pyridyl)acetamide
  • 2-chloro-N-pyridin-2-yl-ethanamide
  • AKOS B015665
  • AKOS BBS-00004069
  • 2-CHLORO-N-PYRIDIN-2-YL-ACETAMIDE
  • ART-CHEM-BB B015665
  • Acetamide, 2-chloro-N-2-pyridinyl-
  • 2-(Chloroacetylamino)pyridine
  • 5221-37-4