3-BROMO-5-METHOXY BENZONITRILE
- Product Name
- 3-BROMO-5-METHOXY BENZONITRILE
- CAS No.
- 867366-91-4
- Chemical Name
- 3-BROMO-5-METHOXY BENZONITRILE
- Synonyms
- 3-Bromo-5-cyanoanisole;3-BROMO-5-METHOXYBENZOTRILE;3-BROMO-5-METHOXY BENZONITRILE;Benzonitrile, 3-bromo-5-methoxy-;3-Bromo-5-methoxybenzonitrile 99%;3-BROMO-5-METHOXYBENZONITRILE,98%;3-Bromo-5-cyanoanisole, 5-Bromo-m-anisonitrile
- CBNumber
- CB2226606
- Molecular Formula
- C8H6BrNO
- Formula Weight
- 212.04
- MOL File
- 867366-91-4.mol
3-BROMO-5-METHOXY BENZONITRILE Property
- Boiling point:
- 253.5±25.0 °C(Predicted)
- Density
- 1.56±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- crystalline solid
- color
- White
Safety
- RIDADR
- UN3439
- HazardClass
- 6.1
- HS Code
- 2926907090
N-Bromosuccinimide Price
- Product number
- B699480
- Product name
- 3-Bromo-5-methoxybenzonitrile
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR17817
- Product name
- 3-Bromo-5-methoxybenzonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $43
- Updated
- 2021/12/16
- Product number
- 4637-9-Y7
- Product name
- 3-Bromo-5-methoxybenzonitrile
- Purity
- 99%
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
- Product number
- FB139554
- Product name
- 3-Bromo-5-methoxybenzonitrile
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- J55584
- Product name
- 3-Bromo-5-methoxybenzonitrile
- Packaging
- 5g
- Price
- $63
- Updated
- 2021/12/16
3-BROMO-5-METHOXY BENZONITRILE Chemical Properties,Usage,Production
Synthesis
867366-90-3
867366-91-4
The general procedure for the synthesis of 3-bromo-5-methoxybenzonitrile from the compound (CAS:867366-90-3) is as follows: a mixed solution of aldehyde 180b (12.0 g, 56 mmol), hydroxylamine hydrochloride (19.4 g, 5 eq.), ethanol (100 mL), and pyridine (10 mL) was heated to 65 °C and reacted for 16 hours. After completion of the reaction, the mixture was cooled to room temperature and extracted by partitioning with 50% ethyl acetate/hexane and water. The organic layer was washed with brine and dried with magnesium sulfate. After evaporation of the volatiles, 12.4 g of the oxime product was obtained (97% yield). The resulting oxime was dissolved in anhydrous dioxane (100 mL) and pyridine (26 mL, 6 eq.), the solution was cooled to 0 °C and trifluoroacetic anhydride (15 mL, 2 eq.) was added slowly. Subsequently, the mixture was gradually warmed to room temperature and stirred continuously for 2 days. After that, the reaction solution was heated to 60 °C and kept for 1 hour. After completion of the reaction, the mixture was cooled to room temperature and carefully poured into ice water. The mixture was extracted with dichloromethane and the combined organic layers were washed sequentially with water, 1 M hydrochloric acid and brine. The organic layer was dried over magnesium sulfate and the solvent was evaporated to give the target product 180c 10.4 g (90% yield).
References
[1] Patent: US2005/239881, 2005, A1. Location in patent: Page/Page column 47-48
[2] Patent: US2008/20981, 2008, A1. Location in patent: Page/Page column 19
[3] Patent: US2008/45511, 2008, A1. Location in patent: Page/Page column 21
[4] Patent: US2008/293664, 2008, A1. Location in patent: Page/Page column 16
[5] Patent: US2008/249151, 2008, A1. Location in patent: Page/Page column 21
3-BROMO-5-METHOXY BENZONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-5-METHOXY BENZONITRILE manufacturers
- Product
- 3-BROMO-5-METHOXY BENZONITRILE 867366-91-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-30