ChemicalBook > CAS DataBase List > 4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine

Product Name
4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
CAS No.
23000-43-3
Chemical Name
4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
Synonyms
AKOS BBS-00002108;BUTTPARK 75\18-20;4-CHLORO-1-METHYLPYRAZOLO[3,4-D]PYRIMIDINE;4-Chloro-1-methyl-1H-pyrazol[3,4-d]pyrimidine;4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE;1-Methyl-4-chloro-1H-pyrazolo[3,4-d]pyrimidine;1H-Pyrazolo[3,4-d]pyrimidine, 4-chloro-1-methyl-
CBNumber
CB2226813
Molecular Formula
C6H5ClN4
Formula Weight
168.58
MOL File
23000-43-3.mol
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4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Property

Melting point:
102-104
Boiling point:
294.6±20.0 °C(Predicted)
Density 
1.59±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
pka
1.46±0.10(Predicted)
Appearance
White to yellow Solid
InChI
InChI=1S/C6H5ClN4/c1-11-6-4(2-10-11)5(7)8-3-9-6/h2-3H,1H3
InChIKey
AVFLNALVPBLGEV-UHFFFAOYSA-N
SMILES
C1=NC(Cl)=C2C=NN(C)C2=N1
CAS DataBase Reference
23000-43-3
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Safety

Hazard Note 
Harmful
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368323
Product name
4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
C368323
Product name
4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
Packaging
50mg
Price
$60
Updated
2021/12/16
Apolloscientific
Product number
OR019232
Product name
4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
Packaging
250mg
Price
$43
Updated
2021/12/16
Oakwood
Product number
067568
Product name
4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
Purity
95%
Packaging
1g
Price
$60
Updated
2021/12/16
ChemScene
Product number
CS-W018697
Product name
4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
Purity
97.85%
Packaging
1g
Price
$60
Updated
2021/12/16
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4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties,Usage,Production

Uses

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine is a chlorine-substituted organic compound. It is a crucial compound that could be used as a pharmaceutical intermediate in pharmaceutical synthesis and scientific research.

Synthesis

5399-92-8

74-88-4

23000-43-3

General procedure for the synthesis of 1-methyl-4-chloropyrazolo[3,4-d]pyrimidines from 4-chloro-1H-pyrazolo[3,4-d]pyrimidines (1.88 g, 0.012 mol) and iodomethane (2.56 g, 0.018 mol): 4-chloro-1H-pyrazolo[3,4-d]pyrimidines and NaH (0.864 g, 0.036 mol) suspension in anhydrous DMF (10 mL) was stirred for 30 min. Subsequently, iodomethane was added and the reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the reaction was quenched with 100 mL of water and extracted with EtOAc (60 mL x 3). The organic layers were combined and concentrated under reduced pressure to afford the target product 1-methyl-4-chloropyrazolo[3,4-d]pyrimidine. Yield: 70.8%; 1H-NMR (400 MHz, DMSO-d6) δ 8.85 (s, 1H), 8.44 (s, 1H), 4.08 (s, 3H).

References

[1] Comptes Rendus Chimie, 2017, vol. 20, # 9-10, p. 927 - 933
[2] Molecules, 2017, vol. 22, # 4,
[3] Patent: CN107383014, 2017, A. Location in patent: Paragraph 0079; 0080; 0081; 0082
[4] European Journal of Medicinal Chemistry, 2018, vol. 155, p. 210 - 228

4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine Suppliers

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View Lastest Price from 4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 23000-43-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2020-05-14

23000-43-3, 4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidineRelated Search:

4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 7-chloro-1-methyl-1H-pyrazolo[4,3-d]pyrimidine 4-CHLORO-1-(2,4-DIMETHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(4-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(4-METHOXYPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(3,5-DI-O-TOLUOYL-BETA-D-2-DEOXYRIBOFURANOSYL)PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE 3-CHLORO-5-METHYL-7-TRIFLUOROMETHYL-PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID 7-(CHLORO-DIFLUORO-METHYL)-5-METHYL-PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID 4-CHLORO-1-(4-FLUOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE AKOS BBS-00002140 4-CHLORO-1-(3,5-DIMETHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE 4-CHLORO-1-(3-METHYLPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE AKOS BBS-00005311 AKOS BBS-00002141 IFLAB-BB F2129-0007 IFLAB-BB F2129-0006

  • BUTTPARK 75\18-20
  • AKOS BBS-00002108
  • 4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDINE
  • 4-CHLORO-1-METHYLPYRAZOLO[3,4-D]PYRIMIDINE
  • 4-Chloro-1-methyl-1H-pyrazol[3,4-d]pyrimidine
  • 1-Methyl-4-chloro-1H-pyrazolo[3,4-d]pyrimidine
  • 1H-Pyrazolo[3,4-d]pyrimidine, 4-chloro-1-methyl-
  • 23000-43-3
  • Heterocycle-Pyrimidine series