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Isosorbide dinitrate

Product Name
Isosorbide dinitrate
CAS No.
87-33-2
Chemical Name
Isosorbide dinitrate
Synonyms
ISDN;isordil;sorbide;carvasin;sorbitrate;Lion's Mane;dilatrate-sr;Isosorbide dinitrate CRS;(3R,3aS,6S,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate;cardis
CBNumber
CB2226929
Molecular Formula
C6H8N2O8
Formula Weight
236.14
MOL File
87-33-2.mol
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Isosorbide dinitrate Property

Melting point:
700C
alpha 
D20 +135° (alc)
Boiling point:
378.59°C (rough estimate)
Density 
1.7503 (rough estimate)
refractive index 
1.5010 (estimate)
storage temp. 
-20°C Freezer
solubility 
Undiluted isosorbide dinitrate is very slightly soluble in water, very soluble in acetone, sparingly soluble in ethanol (96 per cent). The solubility of the diluted product depends on the diluent and its concentration.
form 
Solid
color 
White to Off-White
Water Solubility 
549.7mg/L(25 ºC)
BCS Class
3
InChIKey
MOYKHGMNXAOIAT-JGWLITMVSA-N
LogP
1.31 at 25℃
CAS DataBase Reference
87-33-2(CAS DataBase Reference)
EPA Substance Registry System
D-Glucitol, 1,4:3,6-dianhydro-, dinitrate (87-33-2)
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Safety

Hazard Codes 
Xn
Risk Statements 
5-22
Safety Statements 
36
RIDADR 
UN 2907
HazardClass 
4.1
PackingGroup 
II
HS Code 
2932999000
Hazardous Substances Data
87-33-2(Hazardous Substances Data)
Toxicity
LD50 oral in rat: 747mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P230Keep wetted with …

P233Keep container tightly closed.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P380+P375in case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23990
Product name
Isosorbide Dinitrate
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23990
Product name
Isosorbide Dinitrate
Purity
≥98%
Packaging
10mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
23990
Product name
Isosorbide Dinitrate
Purity
≥98%
Packaging
25mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
23990
Product name
Isosorbide Dinitrate
Purity
≥98%
Packaging
50mg
Price
$184
Updated
2024/03/01
Usbiological
Product number
293783
Product name
Isosorbide dinitrate
Packaging
10mg
Price
$340
Updated
2021/12/16
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Isosorbide dinitrate Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Originator

Isordil,Ives,US,1959

Uses

Coronary vasodilator

Uses

Isosorbide dinitrate is also used in chronic cardiac insufficiency for preventing angina pectoris attacks. It is a long-lasting drug.

Uses

Antianginal;Nitric oxide (NO) donor

Definition

ChEBI: Isosorbide dinitrate is a nitrate ester and a glucitol derivative. It has a role as a vasodilator agent and a nitric oxide donor.

Manufacturing Process

An aqueous syrup of 1,4:3,6-dianhydro-D-glucitol is slowly added to a cooled mixture of HNO3 and H2SO4. After standing a few minutes the mixture is poured into cold water and the precipitated product is collected and recrystallized from ethanol.

brand name

Dilatrate (Schwarz Pharma); Isordil (Biovail); Isordil (Wyeth); Sorbitrate (AstraZeneca).

Therapeutic Function

Coronary vasodilator

General Description

A crystalline solid. May be toxic by ingestion. Used to make pharmaceuticals. Used as a heart drug.

Air & Water Reactions

Highly flammable. Slightly soluble in water.

Reactivity Profile

Nitroalkanes, such as Isosorbide dinitrate, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. Nitroalkanes are milder oxidizing agents, but still react violently with reducing agents at higher temperature and pressures. Nitroalkanes react with inorganic bases to form explosive salts. The presence of metal oxides increases the thermal sensitivity of nitroalkanes. Nitroalkanes with more than one nitro group are generally explosive. Nitroalkanes are insoluble in water. This heart drug is detonable when dry, but non-explosive with 30% of water.

Health Hazard

Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.

Fire Hazard

Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.

Clinical Use

Vasodilator:
Prophylaxis and treatment of angina
Left ventricular failure

Safety Profile

Moderately toxic by ingestion, intraperitoneal, intramuscular, and subcutaneous routes. Experimental reproductive effects. Mutation data reported. A flammable solid. When heated to decomposition it emits toxic fumes of NOx. A coronary vasodilator. See also NITRATES.

Synthesis

Isosorbiddinitrate, 1,4:3,6-dianhydrosorbate-2,5-dinitrate (19.1.4), is synthesized by intermolecular dehydration of D-sorbite into isosorbide (19.1.3) using paratoluenesulfonic acid and subsequent nitration of the two hydroxyl groups by nitric acid.

Veterinary Drugs and Treatments

Isosorbide mononitrate (ISMN) and dinitrate (ISDN) are organic nitrates potentially useful as preload reducing agents in treating heart failure in small animals, however, research and clinical experience demonstrating clinical efficacy are lacking in dogs or cats. Limited research indicates that dogs may require much higher dosages of isosorbide dinitrate to achieve therapeutic effects than do humans.
In humans, isosorbide nitrates are used for treating or preventing angina, treating esophageal spasm, and as an adjunctive treatment in CHF.

Isosorbide dinitrate Preparation Products And Raw materials

Raw materials

D-Sorbitol SORBITOL SOLUTION 70 Sorbitol

Preparation Products

Isosorbide 5-mononitrate
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Isosorbide dinitrate Suppliers

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View Lastest Price from Isosorbide dinitrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Isosorbide dinitrate dinitrate 40% 87-33-2
Price
US $0.00/KG
Min. Order
1KG
Purity
38%～42%,EP10
Supply Ability
100kg/month
Release date
2021-06-19
airuikechemical co., ltd.
Product
isosorbide dinitrate 87-33-2
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.9%
Supply Ability
20 tons
Release date
2024-04-07
Hebei Chuanghai Biotechnology Co,.LTD
Product
Isosorbide Dinitrate 87-33-2
Price
US $10.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10 ton
Release date
2024-08-20

87-33-2, Isosorbide dinitrateRelated Search:

Isosorbide Isosorbide 5-mononitrate ISOSORBIDE 2-MONONITRATE ZIRCONIUM DINITRATE OXIDE THORIUM NITRATE HYDRATE Lanthanum(III) nitrate hexahydrate Sodium nitroprusside dihydrate Ceric ammonium nitrate Nitrazine Yellow NICLOFOLAN Cobaltous nitrate hexahydrate Erbium(III) nitrate pentahydrate Ferric nitrate nonahydrate CERIUM(III) NITRATE HEXAHYDRATE Ferric nitrate LANTHANUM NITRATE Lithium nitrate MERCUROUS NITRATE

  • 1,4:3,6-dianhydro-,dinitrate,d-glucito
  • 1,4:3,6-dianhydro-d-glucitodinitrate
  • 1,4:3,6-dianhydrosorbitol2,5-dinitrate
  • cardis
  • carvanil
  • carvasin
  • [(3S,3aS,6R,6aS)-6-Nitrooxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl] nitrate
  • Isosorbitol dinitrate
  • Isosorbide dinitrate,ISDN
  • Diluted Isosorbide Dinitrate (500 mg of 25% mixture with mannitol)
  • Isosorbide Dinitrate(contains approx. 60% Lactose)
  • (3R,3aS,6S,6aS)-hexahydrofuro[3,2-b]furan-3,6-diyl dinitrate
  • Isosorbide Dinitrate EP
  • Lion's Mane
  • cedocard
  • claodical
  • corosorbide
  • dianhydrosorbitol2,5-dinitrate
  • dinitrosorbide
  • flindix
  • frandol
  • harrical
  • iso-bid
  • isochron
  • isoket
  • isorbid
  • isordil
  • isordiltembids
  • korodil
  • laserdil
  • maycor
  • nitrosorbid
  • nitrosorbide
  • resoidan
  • rigedal
  • sorate-10
  • sorate-5
  • sorbangil
  • sorbide
  • sorbide,dinitrate
  • sorbidenitrate
  • sorbidilat
  • sorbidinitrate
  • sorbidnitrate
  • sorbitrate
  • sorbonit
  • sorquad
  • sorquat
  • sst-101
  • tyb3215
  • vascardin
  • vasorbate
  • 1,4:3,6-dianhydro-d-glucitol dinitrate
  • ISOSORBIDE DINITRATE
  • ISDN
  • dilatrate-sr
  • 1,4:3,6-Dianhydrosorbitol 2,5-Dinitrate, Carvasin
  • Corovliss