1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
- Product Name
- 1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
- CAS No.
- 1469902-72-4
- Chemical Name
- 1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
- Synonyms
- Kv1.5IN4;Kv1.5INIV;COMPOUND 4;Kv1.5INIIII;Compound IIII;Kv1.5-IN-IIII;Kv-1.5-IN-IIII,Kv1.5 IN IIII;1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
- CBNumber
- CB2228963
- Molecular Formula
- C19H18ClNO3
- Formula Weight
- 343.8
- MOL File
- Mol file
1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID Property
- solubility
- DMSO: 10 mg/mL, soluble
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- HCH0067158
- Product name
- 1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $721.64
- Updated
- 2021/12/16
1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID Chemical Properties,Usage,Production
Uses
Kv1.5-IN-1 is a Kv1.5 channel inhibitor. Its target selectivity and pharmacodynamic effects were evaluated in an in vitro rat model. After the introduction of a methoxy group at the R5 position, Kv1.5-IN-1 showed inhibitory potency similar to that of the unsubstituted compound. Its IC50 value for hKv1.5 channels was 0.51 μM. Kv1.5-IN-1 exhibited a high degree of selectivity, nearly 2,600 times higher than compound Ik and 300 times higher than compound IId, indicating that it may be a safe inhibitor. Due to its good pharmacological behavior, Kv1.5-IN-1 deserves further pharmacodynamic and pharmacokinetic evaluation. These properties make Kv1.5-IN-1 a potential Kv1.5 channel inhibitor that may have application prospects in the treatment of related diseases.
References
[1] Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors
1-(4-CHLOROBENZYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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