ChemicalBook > CAS DataBase List > MDL-29951

MDL-29951

Product Name
MDL-29951
CAS No.
130798-51-5
Chemical Name
MDL-29951
Synonyms
CS-1105;MDL-29951, >=98%;MDL-29951; MDL29951;2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid;2-Carboxy-4,6-dichloro-1H-indole-3-propionic acid;3-(2-carboxy-4,6-dichloroindol-3-yl)propionic acid;1H-Indole-3-propanoic acid, 2-carboxy-4,6-dichloro-;3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid;MDL-29951 2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid
CBNumber
CB22292210
Molecular Formula
C12H9Cl2NO4
Formula Weight
302.11
MOL File
130798-51-5.mol
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MDL-29951 Property

Melting point:
273-280℃
Boiling point:
582.5±45.0 °C(Predicted)
Density 
1.657±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
Soluble in DMSO (up to 15 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
form 
solid
pka
4.04±0.30(Predicted)
color 
Off-white
Stability:
Stable for 2 years from date of pruchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16266
Product name
MDL 29951
Purity
≥98%
Packaging
500μg
Price
$51
Updated
2024/03/01
Cayman Chemical
Product number
16266
Product name
MDL 29951
Purity
≥98%
Packaging
1mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
16266
Product name
MDL 29951
Purity
≥98%
Packaging
5mg
Price
$202
Updated
2024/03/01
Cayman Chemical
Product number
16266
Product name
MDL 29951
Purity
≥98%
Packaging
10mg
Price
$354
Updated
2024/03/01
TRC
Product number
M199790
Product name
MDL29951
Packaging
25mg
Price
$150
Updated
2021/12/16
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MDL-29951 Chemical Properties,Usage,Production

Description

NMDA receptors are neuroreceptors that have binding sites for glycine or D-serine as well as L-glutamate. MDL 29951 is an antagonist of NMDA receptors with high affinity for the glycine binding site (Ki = 140 nM). It is functional both in vitro and in vivo. MDL 29951 blocks NMDA receptor-dependent convulsions in audiogenic seizure-susceptible DBA/2J mice. It is used to evaluate the role of the glycine site of the NMDA receptor in neurological signaling. MDL 29951 is also an agonist of the G protein-coupled receptor GPR17 (EC50 values range from 7 nM to 6 μM, depending on the assay). GPR17 is thought to be involved in oligodendrocyte differentiation and myelin formation/repair.

Uses

MDL 29951 is an allosteric inhibitor of the enzyme fructose 1,6-bisphosphatase.

References

1) Hennen?et al. (2013),?Decoding Signaling and Function of the Orphan Protein-Coupled Receptor GPR17 with a small molecule agonist; Sci. Signal.,?6?ra93 2) Salituro?et al. (1992)?3-(2-Carboxyindol-3-yl)propionic Acid-Based Antagonists of the N-Methyl-D-aspartic Acid Receptor Associated Glycine Binding Site; J. Med. Chem.,?35?1791

MDL-29951 Preparation Products And Raw materials

Raw materials

Preparation Products

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MDL-29951 Suppliers

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View Lastest Price from MDL-29951 manufacturers

Career Henan Chemical Co
Product
MDL-29951 130798-51-5
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-09-03

130798-51-5, MDL-29951Related Search:

6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Bromocriptine mesylate EPPTB

  • 2-Carboxy-4,6-dichloro-1H-indole-3-propionic acid
  • 3-(2-carboxyethyl)-4,6-dichloro-1H-indole-2-carboxylic acid
  • 2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid
  • MDL-29951 2-Carboxy-4,6-dichloro-1H-indole-3-propanoic acid
  • MDL-29951, >=98%
  • 3-(2-carboxy-4,6-dichloroindol-3-yl)propionic acid
  • CS-1105
  • MDL-29951; MDL29951
  • 1H-Indole-3-propanoic acid, 2-carboxy-4,6-dichloro-
  • 130798-51-5
  • Inhibitors