ChemicalBook > CAS DataBase List > N-(3-BROMOPROPYL)PHTHALIMIDE

N-(3-BROMOPROPYL)PHTHALIMIDE

Product Name: N-(3-BROMOPROPYL)PHTHALIMIDE
CAS No.: 5460-29-7
Chemical Name: N-(3-BROMOPROPYL)PHTHALIMIDE
Synonyms: 2-(3-BROMO-PROPYL)-ISOINDOLE-1,3-DIONE;AKOS 226-47;AURORA KA-570;TIMTEC-BB SBB003049;LABOTEST-BB LT00455358;(3-bromopropyl)phthalimide;N-(3-Bromopropyl)phthahmide;N-(3-bromopropyl)pthalimide;N-(3-BROMOPROPYL)PHTHALIMIDE;GAMMA-BROMOPROPYLPHTHALIMIDE
CBNumber: CB2237116
Molecular Formula: C11H10BrNO2
Formula Weight: 268.11
MOL File: 5460-29-7.mol

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N-(3-BROMOPROPYL)PHTHALIMIDE Property

Melting point:: 72-74 °C(lit.)
Boiling point:: 361℃
Density: 1.578
refractive index: 1.6320 (estimate)
Flash point:: 172℃
storage temp.: Inert atmosphere,Room Temperature
solubility: <1g/l
form: Crystalline Powder or Crystals
pka: -2.21±0.20(Predicted)
color: White to light beige
BRN: 157547
InChI: InChI=1S/C11H10BrNO2/c12-6-3-7-13-10(14)8-4-1-2-5-9(8)11(13)15/h1-2,4-5H,3,6-7H2
InChIKey: VKJCJJYNVIYVQR-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=CC=C2)C(=O)N1CCCBr
CAS DataBase Reference: 5460-29-7(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 22-24/25
WGK Germany: 3
HS Code: 29251900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B80003
Product name: N-(3-Bromopropyl)phthalimide
Purity: 98%
Packaging: 25g
Price: $39.61
Updated: 2025/07/31

Sigma-Aldrich

Product number: B80003
Product name: N-(3-Bromopropyl)phthalimide
Purity: 98%
Packaging: 100g
Price: $120
Updated: 2025/07/31

TCI Chemical

Product number: B1328
Product name: N-(3-Bromopropyl)phthalimide
Purity: >98.0%(HPLC)(N)
Packaging: 25g
Price: $61
Updated: 2025/07/31

TCI Chemical

Product number: B1328
Product name: N-(3-Bromopropyl)phthalimide
Purity: >98.0%(HPLC)(N)
Packaging: 500g
Price: $648
Updated: 2025/07/31

TRC

Product number: B688636
Product name: N-(3-Bromopropyl)phthalimide
Packaging: 25g
Price: $90
Updated: 2021/12/16

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N-(3-BROMOPROPYL)PHTHALIMIDE Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

N-(3-Bromopropyl)phthalimide is used in synthesis of several organic compounds including that of flavonoid derivatives which act as selective ABCC1 modulators with potential use as pharmacological tools for investigation of the role of ABCC1. It is also used in the synthesis of Hederagenin which is a triterpene template for the development of new antitumor compounds.

reaction suitability

reagent type: cross-linking reagent

Synthesis

1074-82-4

109-64-8

5460-29-7

In 50 mL of DMF, 0.025 mol of phthalimide potassium salt, 0.10 mol of 1,3-dibromopropane and 0.5 g of TBAB were added and the reaction was carried out at 70°C for 2.0 hours. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water and extracted with ethyl acetate. The organic phase was sequentially washed with water, dried, concentrated and allowed to stand overnight to give 5.91 g of N-(3-bromopropyl)phthalimide as a white solid with a melting point of 70-73°C and a yield of 88.3%.

Purification Methods

Place it in a Soxhlet and extract it with Et2O, whereby the bis-phthalimido impurity is not extracted. Evaporate the Et2O and recrystallise the residue from EtOH, aqueous EtOH or pet ether. [Gabriel & Weiner Chem Ber 21 2669 1888, Gaudry Can J Chem 31 1060 1953, Beilstein 21/10 V 1277.]

References

[1] Patent: CN107382980, 2017, A. Location in patent: Paragraph 0035; 0036; 0037; 0038
[2] Patent: CN107540647, 2018, A. Location in patent: Paragraph 0049-0051
[3] European Journal of Medicinal Chemistry, 2018, vol. 149, p. 69 - 78
[4] Chemistry - A European Journal, 2014, vol. 20, # 6, p. 1530 - 1538
[5] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 7, p. 1223 - 1227

N-(3-BROMOPROPYL)PHTHALIMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N,N-DIBUTYL-1,3-PROPANEDIAMINE

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View Lastest Price from N-(3-BROMOPROPYL)PHTHALIMIDE manufacturers

YiZheng HaiFan Chemical CO., LTD.

Product: N-(3-bromopropyl)phthalimide 5460-29-7
Price: US $0.00/kgs/paper drum
Min. Order: 25kgs/paper drum
Purity: 98%
Supply Ability: 50 tons
Release date: 2025-12-04

Jinan Ruitong Biotech Co., Ltd.

Product: N-(3-Bromopropyl)phthalimide?? 5460-29-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-27

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: N-(3-Bromopropyl)phthalimide 5460-29-7
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-27

5460-29-7, N-(3-BROMOPROPYL)PHTHALIMIDERelated Search:

N-(2-Bromoethyl)phthalimide N-(3-BROMOPROPYL)PHTHALIMIDE N,N-Dimethylbenzamide N-Benzyl-N-propylamine TRIETHYLAMINE HYDROBROMIDE N-N-PROPYLPHTHALIMIDE N-ETHYLPHTHALIMIDE N,N-Diethylformamide DIMETHYLAMINE HYDROBROMIDE N-METHYL-N-(2-METHYLBENZYL)AMINE N-BENZYLFORMAMIDE N-Methylphthalimide DIETHYLAMINE HYDROBROMIDE (3-BROMO-PROPYL)-DIMETHYL-AMINE PHTHALAMIDE CHEMBRDG-BB 9070943 2-METHYLISOINDOLIN-1-ONE N-METHYL-O-TOLUAMIDE

AURORA KA-570

GAMMA-BROMOPROPYLPHTHALIMIDE

LABOTEST-BB LT00455358

2-(3-BROMO-PROPYL)-ISOINDOLE-1,3-DIONE

2-(3-BROMOPROPYL)-1H-ISOINDOLE-1,3(2H)-DIONE

AKOS 226-47

TIMTEC-BB SBB003049

N-(3-BROMOPROPYL)PHTHALIMIDE

2-(3-Bromoprop-1-yl)-1H-isoindole-1,3(2H)-dione, 2-(3-Bromoprop-1-yl)isoindoline-1,3-dione

N-(3-Bromoprop-1-yl)phthalimide

1-Phthalimido-3-bromopropane

2-(3-Bromopropyl)-1H-isoindol-1,3(2H)-dione

N-(3-BroMopropyl)phthaliMide, 98% 25GR

N-(3-BROMOPROPYL)PHTHALIMIDE FOR SYNTHES

2-(BroMopropyl)-1,3-dihydro-1,3-dioxoisoindole

N-(3-BroMopropyl)phthaliMide 98%

N-(3-Bromopropyl)phthahmide

BROMOPROPYLPHTHALIMIDEN3()--

N-(3-Bromopropyl)-Phthalimide~97%

N-(3-Bromopropyl)phthalimide,98%

1H-Isoindole-1,3(2H)-dione, 2-(3-bromopropyl)-

(3-bromopropyl)phthalimide

N-(3-bromopropyl)pthalimide

2-(3-bromopropyl)isoindoline-1,3-dione hydrochloride

2-(3-BroMopropyl)isoindoline-1.3-dione

N-(3-Bromopropyl)phthalimide &gt

Dimethyl 26-bromo terephthalate

<i>N</i>-(3-Bromopropyl)phthalimide

5460-29-7

N-Substituted Phthalimides

N-Substituted Maleimides, Succinimides & Phthalimides

AMINE

Cyclic Imides

Organic Building Blocks

Building Blocks

Carbonyl Compounds

alkyl bromide

N-Substituted Maleimides, Succinimides & Phthalimides

N-Substituted Phthalimides

Bifunctional CrosslinkersOrganic Building Blocks

Carbonyl Compounds

Cyclic Imides

Linkers

Peptide Synthesis