N-(3-BROMOPROPYL)PHTHALIMIDE
- Product Name
- N-(3-BROMOPROPYL)PHTHALIMIDE
- CAS No.
- 5460-29-7
- Chemical Name
- N-(3-BROMOPROPYL)PHTHALIMIDE
- Synonyms
- 2-(3-BROMO-PROPYL)-ISOINDOLE-1,3-DIONE;AKOS 226-47;AURORA KA-570;TIMTEC-BB SBB003049;LABOTEST-BB LT00455358;(3-bromopropyl)phthalimide;N-(3-Bromopropyl)phthahmide;N-(3-bromopropyl)pthalimide;N-(3-BROMOPROPYL)PHTHALIMIDE;GAMMA-BROMOPROPYLPHTHALIMIDE
- CBNumber
- CB2237116
- Molecular Formula
- C11H10BrNO2
- Formula Weight
- 268.11
- MOL File
- 5460-29-7.mol
N-(3-BROMOPROPYL)PHTHALIMIDE Property
- Melting point:
- 72-74 °C(lit.)
- Boiling point:
- 361℃
- Density
- 1.578
- refractive index
- 1.6320 (estimate)
- Flash point:
- 172℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- <1g/l
- form
- Crystalline Powder or Crystals
- pka
- -2.21±0.20(Predicted)
- color
- White to light beige
- BRN
- 157547
- InChI
- InChI=1S/C11H10BrNO2/c12-6-3-7-13-10(14)8-4-1-2-5-9(8)11(13)15/h1-2,4-5H,3,6-7H2
- InChIKey
- VKJCJJYNVIYVQR-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=CC=C2)C(=O)N1CCCBr
- CAS DataBase Reference
- 5460-29-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B80003
- Product name
- N-(3-Bromopropyl)phthalimide
- Purity
- 98%
- Packaging
- 25g
- Price
- $39.61
- Updated
- 2025/07/31
- Product number
- B80003
- Product name
- N-(3-Bromopropyl)phthalimide
- Purity
- 98%
- Packaging
- 100g
- Price
- $120
- Updated
- 2025/07/31
- Product number
- B1328
- Product name
- N-(3-Bromopropyl)phthalimide
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 25g
- Price
- $61
- Updated
- 2025/07/31
- Product number
- B1328
- Product name
- N-(3-Bromopropyl)phthalimide
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 500g
- Price
- $648
- Updated
- 2025/07/31
- Product number
- B688636
- Product name
- N-(3-Bromopropyl)phthalimide
- Packaging
- 25g
- Price
- $90
- Updated
- 2021/12/16
N-(3-BROMOPROPYL)PHTHALIMIDE Chemical Properties,Usage,Production
Chemical Properties
white powder
Uses
N-(3-Bromopropyl)phthalimide is used in synthesis of several organic compounds including that of flavonoid derivatives which act as selective ABCC1 modulators with potential use as pharmacological tools for investigation of the role of ABCC1. It is also used in the synthesis of Hederagenin which is a triterpene template for the development of new antitumor compounds.
reaction suitability
reagent type: cross-linking reagent
Synthesis
1074-82-4
109-64-8
5460-29-7
In 50 mL of DMF, 0.025 mol of phthalimide potassium salt, 0.10 mol of 1,3-dibromopropane and 0.5 g of TBAB were added and the reaction was carried out at 70°C for 2.0 hours. After completion of the reaction, the mixture was cooled to room temperature, poured into ice water and extracted with ethyl acetate. The organic phase was sequentially washed with water, dried, concentrated and allowed to stand overnight to give 5.91 g of N-(3-bromopropyl)phthalimide as a white solid with a melting point of 70-73°C and a yield of 88.3%.
Purification Methods
Place it in a Soxhlet and extract it with Et2O, whereby the bis-phthalimido impurity is not extracted. Evaporate the Et2O and recrystallise the residue from EtOH, aqueous EtOH or pet ether. [Gabriel & Weiner Chem Ber 21 2669 1888, Gaudry Can J Chem 31 1060 1953, Beilstein 21/10 V 1277.]
References
[1] Patent: CN107382980, 2017, A. Location in patent: Paragraph 0035; 0036; 0037; 0038
[2] Patent: CN107540647, 2018, A. Location in patent: Paragraph 0049-0051
[3] European Journal of Medicinal Chemistry, 2018, vol. 149, p. 69 - 78
[4] Chemistry - A European Journal, 2014, vol. 20, # 6, p. 1530 - 1538
[5] Bioorganic and Medicinal Chemistry Letters, 2018, vol. 28, # 7, p. 1223 - 1227
N-(3-BROMOPROPYL)PHTHALIMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-(3-BROMOPROPYL)PHTHALIMIDE Suppliers
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View Lastest Price from N-(3-BROMOPROPYL)PHTHALIMIDE manufacturers
- Product
- N-(3-bromopropyl)phthalimide 5460-29-7
- Price
- US $0.00/kgs/paper drum
- Min. Order
- 25kgs/paper drum
- Purity
- 98%
- Supply Ability
- 50 tons
- Release date
- 2025-12-04
- Product
- N-(3-Bromopropyl)phthalimide?? 5460-29-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-27
- Product
- N-(3-Bromopropyl)phthalimide 5460-29-7
- Price
- US $3.00-9.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-27