Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
- Product Name
- Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
- CAS No.
- 22200-69-7
- Chemical Name
- Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
- Synonyms
- Seriniquinone;Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone
- CBNumber
- CB22387534
- Molecular Formula
- C20H8O4S
- Formula Weight
- 344.34
- MOL File
- 22200-69-7.mol
Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Property
- Melting point:
- 288 °C
- Boiling point:
- 612.3±54.0 °C(Predicted)
- Density
- 1.578±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 15 mg/ml with warming) or in DMF (up to 15 mg/ml)
- form
- solid
- color
- Orange
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- BVT-0478-M001
- Product name
- Seriniquinone
- Purity
- ≥99%(HPLC)
- Packaging
- 1mg
- Price
- $60
- Updated
- 2021/12/16
Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Chemical Properties,Usage,Production
Description
Seriniquinone (22200-69-7) is a new natural product isolated from a marine bacterium of the genus Serinicoccus. Displays selective toxicity against a distinct set of cell lines (within the NCI 60 panel) predominantly melanoma. Upon cellular treatment, seriniquinone was found to localize in the endoplasmic reticulum. Within 3 hours cells underwent autophagy followed by death via a caspase-9 apoptotic pathway. The target of seriniquinone was identified as the small protein, dermcidin, as determined using an immunoaffinity approach.1
Uses
Seriniquinone is a marine natural product, that displays potent cytotoxicity and selectivity against melanoma cancer cells.
References
[1] LYNNIE TRZOSS. Seriniquinone, a selective anticancer agent, induces cell death by autophagocytosis, targeting the cancer-protective protein dermcidin.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 41: 14687-14692. DOI:10.1073/pnas.1410932111
Dinaphtho[2,3-b:2',3'-d]thiophene-5,7,12,13-tetrone Preparation Products And Raw materials
Raw materials
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